AutismKB 2.0

Annotation Details for RBPJ


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Basic Information Top
Gene Symbol:RBPJ ( CBF1,IGKJRB,IGKJRB1,KBF2,MGC61669,RBP-J,RBPJK,RBPSUH,SUH,csl )
Gene Full Name: recombination signal binding protein for immunoglobulin kappa J region
Band: 4p15.2
Quick LinksEntrez ID:3516; OMIM: 147183; Uniprot ID:SUH_HUMAN; ENSEMBL ID: ENSG00000168214; HGNC ID: 5724
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0002193IDA-MAML1-RBP-Jkappa- ICN1 complex16510869
GO:0005634IDA-nucleus9874765
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005667IEA-transcription factor complex-
GO:0005730IDA-nucleolus9874765
GO:0005737IDA-cytoplasm21102556
GO:0017053IDA-transcriptional repressor complex16691198
GO ID Evidence Qualifier GO_term References
GO:0000150NAS-recombinase activity8406481
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding16691198
GO:0000979IEA-RNA polymerase II core promoter sequence-specific DNA binding-
GO:0001077IDA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding18663143
GO:0001103IPI-RNA polymerase II repressing transcription factor binding16287852
GO:0003677TAS-DNA binding9874765
GO:0003682IEA-chromatin binding-
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding9874765
GO:0005515IPI-protein binding8627785
GO:0008134IDA-transcription factor binding23303788
GO:0008134IPI-transcription factor binding23303788
GO:0043565IDA-sequence-specific DNA binding23303788
GO:0047485IEA-protein N-terminus binding-
GO:0070491IPI-repressing transcription factor binding16691198
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter18663143
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter-
GO:0001525ISS-angiogenesis-
GO:0001756IEA-somitogenesis-
GO:0001837ISS-epithelial to mesenchymal transition-
GO:0001974IEA-blood vessel remodeling-
GO:0002437IEA-inflammatory response to antigenic stimulus-
GO:0003139IEA-secondary heart field specification-
GO:0003151ISS-outflow tract morphogenesis-
GO:0003160ISS-endocardium morphogenesis-
GO:0003198ISS-epithelial to mesenchymal transition involved in endocardial cushion formation-
GO:0003214ISS-cardiac left ventricle morphogenesis-
GO:0003222ISS-ventricular trabecula myocardium morphogenesis-
GO:0003256ISS-regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation-
GO:0006310NAS-DNA recombination8406481
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0006959IEA-humoral immune response-
GO:0007219IMP-Notch signaling pathway18663143
GO:0007219TAS-Notch signaling pathway-
GO:0007221IDA-positive regulation of transcription of Notch receptor target21102556
GO:0008285IEA-negative regulation of cell proliferation-
GO:0009912IEA-auditory receptor cell fate commitment-
GO:0009957IEA-epidermal cell fate specification-
GO:0021983IEA-pituitary gland development-
GO:0030183IEA-B cell differentiation-
GO:0030216IEA-keratinocyte differentiation-
GO:0030279ISS-negative regulation of ossification-
GO:0030513ISS-positive regulation of BMP signaling pathway-
GO:0035019IEA-somatic stem cell population maintenance-
GO:0035912ISS-dorsal aorta morphogenesis-
GO:0036302ISS-atrioventricular canal development-
GO:0042742IEA-defense response to bacterium-
GO:0043011IEA-myeloid dendritic cell differentiation-
GO:0045596IEA-negative regulation of cell differentiation-
GO:0045892IDA-negative regulation of transcription, DNA-templated10713164
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter18663143
GO:0048505IEA-regulation of timing of cell differentiation-
GO:0048733IEA-sebaceous gland development-
GO:0048820IEA-hair follicle maturation-
GO:0060045ISS-positive regulation of cardiac muscle cell proliferation-
GO:0060486IEA-Clara cell differentiation-
GO:0060716ISS-labyrinthine layer blood vessel development-
GO:0060844IEA-arterial endothelial cell fate commitment-
GO:0061314IC-Notch signaling involved in heart development21311046
GO:0061419IDA-positive regulation of transcription from RNA polymerase II promoter in response to hypoxia23303788
GO:0072554ISS-blood vessel lumenization-
GO:0072602IEA-interleukin-4 secretion-
GO:0097101ISS-blood vessel endothelial cell fate specification-
GO:1901186ISS-positive regulation of ERBB signaling pathway-
GO:1901189ISS-positive regulation of ephrin receptor signaling pathway-
GO:1901297IEA-positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment-
GO:2000138ISS-positive regulation of cell proliferation involved in heart morphogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RBPJKAT2A10973610747963 Two-hybrid
RBPJKAT2A10891810747963 Two-hybrid
NOTCH2RBPJ1097369032325 Two-hybrid
NOTCH2RBPJ1109159032325 Two-hybrid
NOTCH1RBPJ1097369111040 12644465 Affinity Capture-Western; Reconstituted Complex
NOTCH1RBPJ1109139111040 12644465 Affinity Capture-Western; Reconstituted Complex
SND1RBPJ1097369874765 10644367 Two-hybrid
SND1RBPJ1179749874765 10644367 Two-hybrid
CIR1RBPJ1097369874765 Two-hybrid
CIR1RBPJ1149169874765 Two-hybrid
SNW1RBPJ10973610644367 10713164 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SNW1RBPJ11659710644367 10713164 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SIN3ARBPJ10973610644367 Reconstituted Complex
SIN3ARBPJ11743910644367 Reconstituted Complex
KAT2BRBPJ10973610747963 Affinity Capture-Western; Two-hybrid
KAT2BRBPJ11437510747963 Affinity Capture-Western; Two-hybrid
NCOR2RBPJ10973611404076 11509665 Two-hybrid
NCOR2RBPJ11497411404076 11509665 Two-hybrid
SPENRBPJ10973612374742 Reconstituted Complex
SPENRBPJ11665512374742 Reconstituted Complex
MECP2RBPJ10973616763620 Affinity Capture-Western
MECP2RBPJ11036816763620 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96522
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-031117-1'