Gene Symbol:	TICAM2 ( MGC129876,MGC129877,TICAM-2,TIRAP3,TIRP,TRAM )
Gene Full Name:	toll-like receptor adaptor molecule 2
Band:	5q22.3
Quick Links	Entrez ID:353376; OMIM: 608321; Uniprot ID:TCAM2_HUMAN; ENSEMBL ID: ENSG00000243414; HGNC ID: 21354
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005783	IEA	-	endoplasmic reticulum	-
GO:0005794	IEA	-	Golgi apparatus	-
GO:0005886	TAS	-	plasma membrane	-
GO:0010008	TAS	-	endosome membrane	-
GO:0030667	TAS	-	secretory granule membrane	-
GO:0031901	IEA	-	early endosome membrane	-
GO:0031902	IEA	-	late endosome membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0004871	IMP	-	signal transducer activity	12761501
GO:0005515	IPI	-	protein binding	17258210
GO:0005543	IEA	-	phospholipid binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0002756	TAS	-	MyD88-independent toll-like receptor signaling pathway	-
GO:0006954	IEA	-	inflammatory response	-
GO:0007249	TAS	-	I-kappaB kinase/NF-kappaB signaling	-
GO:0032729	IEA	-	positive regulation of interferon-gamma production	-
GO:0032755	IEA	-	positive regulation of interleukin-6 production	-
GO:0034128	TAS	-	negative regulation of MyD88-independent toll-like receptor signaling pathway	-
GO:0034142	TAS	-	toll-like receptor 4 signaling pathway	-
GO:0034145	IMP	-	positive regulation of toll-like receptor 4 signaling pathway	22685567
GO:0035666	TAS	-	TRIF-dependent toll-like receptor signaling pathway	-
GO:0035669	IMP	-	TRAM-dependent toll-like receptor 4 signaling pathway	22685567
GO:0043123	IMP	-	positive regulation of I-kappaB kinase/NF-kappaB signaling	12761501
GO:0043312	TAS	-	neutrophil degranulation	-
GO:0045087	IEA	-	innate immune response	-
GO:0051607	IEA	-	defense response to virus	-
GO:0070266	TAS	-	necroptotic process	-
GO:0070671	IEA	-	response to interleukin-12	-
GO:0071222	IMP	-	cellular response to lipopolysaccharide	22685567
GO:0071651	IEA	-	positive regulation of chemokine (C-C motif) ligand 5 production	-
GO:0097190	TAS	-	apoptotic signaling pathway	-
GO:2000494	IMP	-	positive regulation of interleukin-18-mediated signaling pathway	22685567

Gene Symbol	Interactant	Interaction ID	References	Description
TICAM2	TLR4	131694	17258210 18221795	PCA
TICAM2	TLR4	112954	17258210 18221795	PCA
TICAM2	SARM1	116726	17258210	PCA
TICAM2	SARM1	131694	17258210	PCA

Gene Symbol	Interactant	Interaction ID	References	Description
TICAM2	IL1RAP	178802	12721283	TIRP interacts with IL-1RAcP.
TICAM2	TIRAP	178801	12721283	TIRP interacts with TIRAP.
TICAM2	TICAM1	178800	12721283	TIRP interacts with TRIF.

AutismKB 2.0

Annotation Details for TICAM2