AutismKB 2.0

Annotation Details for FAS


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Basic Information Top
Gene Symbol:FAS ( ALPS1A,APO-1,APT1,CD95,FAS1,FASTM,TNFRSF6 )
Gene Full Name: Fas (TNF receptor superfamily, member 6)
Band: 10q23.31
Quick LinksEntrez ID:355; OMIM: 134637; Uniprot ID:TNR6_HUMAN; ENSEMBL ID: ENSG00000026103; HGNC ID: 11920
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005739IBA-mitochondrion-
GO:0005829IDA-cytosol-
GO:0005829NAS-cytosol7533181
GO:0005886IDA-plasma membrane-
GO:0005886IMP-plasma membrane21625644
GO:0005886TAS-plasma membrane-
GO:0005887IBA-integral component of plasma membrane-
GO:0009897IEA-external side of plasma membrane-
GO:0009986IDA-cell surface22891283
GO:0016604IDA-nuclear body-
GO:0031264IDA-death-inducing signaling complex11101870
GO:0031265IDA-CD95 death-inducing signaling complex20935634
GO:0045121IDA-membrane raft21382479
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0004871TAS-signal transducer activity9360929
GO:0004872NAS-receptor activity7533181
GO:0005031IBA-tumor necrosis factor-activated receptor activity-
GO:0005515IPI-protein binding7536190
GO:0005516IDA-calmodulin binding24914971
GO:0019900IPI-kinase binding7538908
GO:0042802IPI-identical protein binding7536190
GO:0043120IBA-tumor necrosis factor binding-
GO ID Evidence Qualifier GO_term References
GO:0001934IMP-positive regulation of protein phosphorylation11096076
GO:0002377IEA-immunoglobulin production-
GO:0003014IEA-renal system process-
GO:0006461TAS-protein complex assembly10875918
GO:0006915IDA-apoptotic process9681877
GO:0006919TAS-activation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0006924IEA-activation-induced cell death of T cells-
GO:0006925IEA-inflammatory cell apoptotic process-
GO:0006954IBA-inflammatory response-
GO:0006955IBA-immune response-
GO:0007165TAS-signal transduction9360929
GO:0007275IBA-multicellular organism development-
GO:0007623IEA-circadian rhythm-
GO:0008625IEA-extrinsic apoptotic signaling pathway via death domain receptors-
GO:0009636IEA-response to toxic substance-
GO:0010467IEA-gene expression-
GO:0019724IEA-B cell mediated immunity-
GO:0032464IEA-positive regulation of protein homooligomerization-
GO:0032496IBA-response to lipopolysaccharide-
GO:0032872IMP-regulation of stress-activated MAPK cascade11096076
GO:0033209IEA-tumor necrosis factor-mediated signaling pathway-
GO:0034198IMP-cellular response to amino acid starvation11096076
GO:0036337IMP-Fas signaling pathway11096076
GO:0042127IBA-regulation of cell proliferation-
GO:0042981NAS-regulation of apoptotic process7533181
GO:0042981TAS-regulation of apoptotic process-
GO:0043065IDA-positive regulation of apoptotic process21625644
GO:0043065IMP-positive regulation of apoptotic process20935634
GO:0043066TAS-negative regulation of apoptotic process7510905
GO:0045060IEA-negative thymic T cell selection-
GO:0045619IEA-regulation of lymphocyte differentiation-
GO:0045637IEA-regulation of myeloid cell differentiation-
GO:0048536IEA-spleen development-
GO:0050869IEA-negative regulation of B cell activation-
GO:0051260IEA-protein homooligomerization-
GO:0051384IEA-response to glucocorticoid-
GO:0070230IEA-positive regulation of lymphocyte apoptotic process-
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0071285IEA-cellular response to lithium ion-
GO:0071455IMP-cellular response to hyperoxia21382479
GO:0097049IEA-motor neuron apoptotic process-
GO:0097190TAS-apoptotic signaling pathway-
GO:0097191IMP-extrinsic apoptotic signaling pathway22891283
GO:0097192IEA-extrinsic apoptotic signaling pathway in absence of ligand-
GO:0097284IEA-hepatocyte apoptotic process-
GO:0097296TAS-activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway-
GO:0097527IMP-necroptotic signaling pathway16507998
GO:1902041TAS-regulation of extrinsic apoptotic signaling pathway via death domain receptors-
GO:1902042TAS-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-
GO:2001235IMP-positive regulation of apoptotic signaling pathway11096076
GO:2001241IEA-positive regulation of extrinsic apoptotic signaling pathway in absence of ligand-
GO:2001269IMP-positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway11096076
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FADDFAS1143027538907 8967952 9082980 9325248 12107169 15659383 Affinity Capture-Western; Co-crystal Structure; Co-purification; Reconstituted Complex; Two-hybrid
FADDFAS1068517538907 8967952 9082980 9325248 12107169 15659383 Affinity Capture-Western; Co-crystal Structure; Co-purification; Reconstituted Complex; Two-hybrid
FASFAS1068517538908 Two-hybrid
RIPK1FAS1068517538908 Two-hybrid
RIPK1FAS1142747538908 Two-hybrid
FAF1FAS1068518524870 Affinity Capture-Western
FAF1FAS1162988524870 Affinity Capture-Western
FYNFAS1068518626376 Affinity Capture-Western
FYNFAS1088108626376 Affinity Capture-Western
LCKFAS1068518864141 Reconstituted Complex
LCKFAS1101248864141 Reconstituted Complex
SUMO1FAS1068518906799 11112409 Reconstituted Complex; Two-hybrid
SUMO1FAS1131888906799 11112409 Reconstituted Complex; Two-hybrid
CASP10FAS1068519045686 9325248 15659383 Affinity Capture-Western; Co-purification
CASP10FAS1072939045686 9325248 15659383 Affinity Capture-Western; Co-purification
FASLGFAS1068519126929 9228058 12753742 12887920 15659383 Affinity Capture-Western; Co-purification; Reconstituted Complex
FASLGFAS1068529126929 9228058 12753742 12887920 15659383 Affinity Capture-Western; Co-purification; Reconstituted Complex
CFLARFAS1068519208847 9325248 Affinity Capture-Western
CFLARFAS1143649208847 9325248 Affinity Capture-Western
CASP8FAS1068519208847 9325248 15659383 Affinity Capture-Western; Co-purification
CASP8FAS1072919208847 9325248 15659383 Affinity Capture-Western; Co-purification
UBE2IFAS1068519257699 Affinity Capture-Western
UBE2IFAS1131779257699 Affinity Capture-Western
NOL3FAS1068519560245 Phenotypic Suppression
NOL3FAS1144779560245 Phenotypic Suppression
CASP8AP2FAS10685110235259 Affinity Capture-Western
CASP8AP2FAS11531510235259 Affinity Capture-Western
FAIM2FAS10685110535980 Affinity Capture-Western
FAIM2FAS11665910535980 Affinity Capture-Western
TNFSF13FAS10685110706119 Reconstituted Complex
TNFSF13FAS11427810706119 Reconstituted Complex
FBF1FAS10685110978533 Two-hybrid
FBF1FAS12446510978533 Two-hybrid
HIPK3FAS10685111034606 Affinity Capture-Western
HIPK3FAS11542011034606 Affinity Capture-Western
DAXXFAS10685111483955 Reconstituted Complex
DAXXFAS10798511483955 Reconstituted Complex
PDCD6FAS10685111606059 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PDCD6FAS11533311606059 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TNFFAS10685112753742 Affinity Capture-Western
TNFFAS11297912753742 Affinity Capture-Western
BREFAS10685115465831 Affinity Capture-Western
BREFAS11494615465831 Affinity Capture-Western
RHOAFAS10685115659383 Co-purification
RHOAFAS10688015659383 Co-purification
ARHGDIAFAS10685115659383 Co-purification
ARHGDIAFAS10688915659383 Co-purification
MSNFAS10685115659383 Co-purification
MSNFAS11058415659383 Co-purification
MAPK8FAS10685115659383 Co-purification
MAPK8FAS11158515659383 Co-purification
BIDFAS10685115659383 Co-purification
BIDFAS10710615659383 Co-purification
TNFRSF1AFAS10685115659383 Co-purification
TNFRSF1AFAS11298615659383 Co-purification
EZRFAS10685115659383 Co-purification
EZRFAS11327115659383 Co-purification
TNFRSF10BFAS10685115659383 Co-purification
TNFRSF10BFAS11432315659383 Co-purification
C14orf1FAS10685116169070 Two-hybrid
C14orf1FAS11633216169070 Two-hybrid
CRMP1FAS10685116169070 Two-hybrid
CRMP1FAS10779016169070 Two-hybrid
EEF1A1FAS10685116169070 Two-hybrid
EEF1A1FAS10823716169070 Two-hybrid
C1orf103FAS10685116169070 Two-hybrid
C1orf103FAS12090516169070 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
FADDFAS17887815383280 Fas interacts with FADD.
FADDFAS21509915665818 An unspecified isoform of Fas interacts with FADD.
NOL3FAS18244715383280 ARC interacts with an unspecified isoform of Fas.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
FASrs1051070, rs1159120, rs1324551, rs1468063, rs1571011, rs1571013, rs1571020, rs1800682, rs1926188, rs1926195, rs1926196, rs2031612, rs2234767, rs2234768, rs2234978, rs2234979, rs2296600, rs4064, rs874145, rs913943, rs978522, rs982764, rs983751 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:95484
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-061019-2'