AutismKB 2.0

Annotation Details for IL1B


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Basic Information Top
Gene Symbol:IL1B ( IL-1,IL1-BETA,IL1F2 )
Gene Full Name: interleukin 1, beta
Band: 2q14.1
Quick LinksEntrez ID:3553; OMIM: 147720; Uniprot ID:IL1B_HUMAN; ENSEMBL ID: ENSG00000125538; HGNC ID: 5992
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IDA-extracellular region20041150
GO:0005576NAS-extracellular region1919436
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space12483741
GO:0005615IMP-extracellular space3493774
GO:0005764IEA-lysosome-
GO:0005829TAS-cytosol-
GO:0030141IEA-secretory granule-
GO:0070062IEA-extracellular exosome-
GO ID Evidence Qualifier GO_term References
GO:0005125IDA-cytokine activity1919436
GO:0005125IMP-cytokine activity2989698
GO:0005149IBA-interleukin-1 receptor binding-
GO:0005149NAS-interleukin-1 receptor binding1919436
GO:0019904IPI-protein domain specific binding16575408
GO ID Evidence Qualifier GO_term References
GO:0000165IMP-MAPK cascade21147091
GO:0000187IDA-activation of MAPK activity10748004
GO:0001660IEA-fever generation-
GO:0001934IDA-positive regulation of protein phosphorylation10748004
GO:0001934NAS-positive regulation of protein phosphorylation16477012
GO:0002711IC-positive regulation of T cell mediated immunity1919436
GO:0006915TAS-apoptotic process9218611
GO:0006954IDA-inflammatory response10748004
GO:0006954NAS-inflammatory response1919436
GO:0006955IEA-immune response-
GO:0007165TAS-signal transduction9218611
GO:0007267TAS-cell-cell signaling2989698
GO:0007566TAS-embryo implantation16720713
GO:0008285IDA-negative regulation of cell proliferation3493774
GO:0009743IEA-response to carbohydrate-
GO:0010575IDA-positive regulation of vascular endothelial growth factor production12958148
GO:0010575ISS-positive regulation of vascular endothelial growth factor production-
GO:0010628IDA-positive regulation of gene expression21559518
GO:0010829ISS-negative regulation of glucose transport16865359
GO:0014805NAS-smooth muscle adaptation16477012
GO:0019221IDA-cytokine-mediated signaling pathway10748004
GO:0030213IDA-hyaluronan biosynthetic process15100360
GO:0030593IEA-neutrophil chemotaxis-
GO:0030730IDA-sequestering of triglyceride19032770
GO:0030949IC-positive regulation of vascular endothelial growth factor receptor signaling pathway12958148
GO:0031622ISS-positive regulation of fever generation-
GO:0031663IDA-lipopolysaccharide-mediated signaling pathway21147091
GO:0032308ISS-positive regulation of prostaglandin secretion-
GO:0032611IEA-interleukin-1 beta production-
GO:0032725IDA-positive regulation of granulocyte macrophage colony-stimulating factor production20027291
GO:0032729IDA-positive regulation of interferon-gamma production20027291
GO:0032755TAS-positive regulation of interleukin-6 production16865359
GO:0032757IDA-positive regulation of interleukin-8 production19524870
GO:0033129NAS-positive regulation of histone phosphorylation20018936
GO:0033198IEA-response to ATP-
GO:0034116IDA-positive regulation of heterotypic cell-cell adhesion15100360
GO:0034116NAS-positive regulation of heterotypic cell-cell adhesion19281832
GO:0035066NAS-positive regulation of histone acetylation20018936
GO:0035234IEA-ectopic germ cell programmed cell death-
GO:0035505IDA-positive regulation of myosin light chain kinase activity18390750
GO:0035690IDA-cellular response to drug19158679
GO:0042102IDA-positive regulation of T cell proliferation1919436
GO:0042346IDA-positive regulation of NF-kappaB import into nucleus18390750
GO:0043122IDA-regulation of I-kappaB kinase/NF-kappaB signaling10748004
GO:0043407ISS-negative regulation of MAP kinase activity16865359
GO:0043491IMP-protein kinase B signaling21147091
GO:0045080IEA-positive regulation of chemokine biosynthetic process-
GO:0045086IMP-positive regulation of interleukin-2 biosynthetic process2989698
GO:0045410IEA-positive regulation of interleukin-6 biosynthetic process-
GO:0045429IDA-positive regulation of nitric oxide biosynthetic process8383325
GO:0045766ISS-positive regulation of angiogenesis-
GO:0045833ISS-negative regulation of lipid metabolic process16865359
GO:0045840IMP-positive regulation of mitotic nuclear division2989698
GO:0045893IDA-positive regulation of transcription, DNA-templated15100360
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0046330IBA-positive regulation of JNK cascade-
GO:0046627ISS-negative regulation of insulin receptor signaling pathway16865359
GO:0046827NAS-positive regulation of protein export from nucleus19281832
GO:0050691IEA-regulation of defense response to virus by host-
GO:0050766IMP-positive regulation of phagocytosis18201371
GO:0050796IDA-regulation of insulin secretion8383325
GO:0050995IDA-negative regulation of lipid catabolic process19032770
GO:0050996ISS-positive regulation of lipid catabolic process16865359
GO:0050999IDA-regulation of nitric-oxide synthase activity15899045
GO:0051044IDA-positive regulation of membrane protein ectodomain proteolysis18373975
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity10748004
GO:0051092IDA-positive regulation of NF-kappaB transcription factor activity10383454
GO:0051781IEA-positive regulation of cell division-
GO:0060355NAS-positive regulation of cell adhesion molecule production19281832
GO:0060559IDA-positive regulation of calcidiol 1-monooxygenase activity16720713
GO:0070164ISS-negative regulation of adiponectin secretion16865359
GO:0070487IDA-monocyte aggregation15100360
GO:0071260IEP-cellular response to mechanical stimulus19593445
GO:0071310IDA-cellular response to organic substance19158679
GO:0071407IDA-cellular response to organic cyclic compound21147091
GO:0071639IDA-positive regulation of monocyte chemotactic protein-1 production19524870
GO:0097192IEA-extrinsic apoptotic signaling pathway in absence of ligand-
GO:1903140IDA-regulation of establishment of endothelial barrier25816133
GO:2000778IEA-positive regulation of interleukin-6 secretion-
GO:2001240IDA-negative regulation of extrinsic apoptotic signaling pathway in absence of ligand10748004
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
IL1R1IL1B1097697878046 Reconstituted Complex
IL1R1IL1B1097707878046 Reconstituted Complex
MAPK8IP2IL1B10976910756100 Phenotypic Suppression
MAPK8IP2IL1B11708610756100 Phenotypic Suppression
UBE2NIL1B11318211057907 Phenotypic Suppression
UBE2NIL1B10976911057907 Phenotypic Suppression
ZNF675IL1B12811611751921 Phenotypic Suppression
ZNF675IL1B10976911751921 Phenotypic Suppression
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
IL1B-31c>T, IL1B_unknown, rs1143634, rs3087258 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
IL1BIL1B_AvaI, rs1143629, rs1143634, rs16944 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
IL1BIL1B[del], rs1143627, rs1143633, rs1143634, rs16944, rs2853550, rs3136558, rs3917356, rs3917365 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:96543
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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