AutismKB 2.0

Annotation Details for IL4R


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Basic Information Top
Gene Symbol:IL4R ( CD124,IL4RA )
Gene Full Name: interleukin 4 receptor
Band: 16p12.1
Quick LinksEntrez ID:3566; OMIM: 147781; Uniprot ID:IL4RA_HUMAN; ENSEMBL ID: ENSG00000077238; HGNC ID: 6015
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005615IEA-extracellular space-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane2307934
GO:0043235IDA-receptor complex23382219
GO ID Evidence Qualifier GO_term References
GO:0004913TAS-interleukin-4 receptor activity2307934
GO:0005057TAS-signal transducer activity, downstream of receptor2307934
GO:0005515IPI-protein binding8266078
GO ID Evidence Qualifier GO_term References
GO:0002532IEA-production of molecular mediator involved in inflammatory response-
GO:0002639IEA-positive regulation of immunoglobulin production-
GO:0006955TAS-immune response2307934
GO:0007165TAS-signal transduction2307934
GO:0016064IEA-immunoglobulin mediated immune response-
GO:0030728IEA-ovulation-
GO:0035771IEA-interleukin-4-mediated signaling pathway-
GO:0042127IEA-regulation of cell proliferation-
GO:0042832IEA-defense response to protozoan-
GO:0043032IEA-positive regulation of macrophage activation-
GO:0043306IEA-positive regulation of mast cell degranulation-
GO:0043627IEA-response to estrogen-
GO:0045626IEA-negative regulation of T-helper 1 cell differentiation-
GO:0045630IEA-positive regulation of T-helper 2 cell differentiation-
GO:0090197IEA-positive regulation of chemokine secretion-
GO:1901741IEA-positive regulation of myoblast fusion-
GO:1990834IEA-response to odorant-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
IL4RIL410977911786020 Co-crystal Structure
IL4RIL410978011786020 Co-crystal Structure
NCF1IL4R10978010369419 Affinity Capture-Western
NCF1IL4R57572410369419 Affinity Capture-Western
SHC1IL4R10978010652211 11714803 Affinity Capture-Western; Reconstituted Complex
SHC1IL4R11236110652211 11714803 Affinity Capture-Western; Reconstituted Complex
INPP5DIL4R10984711714803 Reconstituted Complex
INPP5DIL4R10978011714803 Reconstituted Complex
PTPN6IL4R11174211714803 Reconstituted Complex
PTPN6IL4R10978011714803 Reconstituted Complex
PTPN11IL4R10978011714803 Reconstituted Complex
PTPN11IL4R11174511714803 Reconstituted Complex
JAK1IL4R10991912133952 Reconstituted Complex
JAK1IL4R10978012133952 Reconstituted Complex
GNB2L1IL4R10978012960323 Reconstituted Complex
GNB2L1IL4R11567112960323 Reconstituted Complex
ARIH2IL4R11569416169070 Two-hybrid
ARIH2IL4R10978016169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
IL4RIL4R_1902A/G Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:105367
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050227-5'