AutismKB 2.0

Annotation Details for IL6


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Basic Information Top
Gene Symbol:IL6 ( BSF2,HGF,HSF,IFNB2,IL-6 )
Gene Full Name: interleukin 6 (interferon, beta 2)
Band: 7p15.3
Quick LinksEntrez ID:3569; OMIM: 147620; Uniprot ID:IL6_HUMAN; ENSEMBL ID: ENSG00000136244; HGNC ID: 6018
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space3023045
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005896IDA-interleukin-6 receptor complex2261637
GO:0009897IEA-external side of plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0005125IDA-cytokine activity3023045
GO:0005125ISS-cytokine activity-
GO:0005125NAS-cytokine activity10443688
GO:0005138IPI-interleukin-6 receptor binding12829785
GO:0005138IPIcontributes_tointerleukin-6 receptor binding12829785
GO:0005138NAS-interleukin-6 receptor binding1883960
GO:0005515IPI-protein binding11238858
GO:0008083IDA-growth factor activity2261637
GO ID Evidence Qualifier GO_term References
GO:0001781IDA-neutrophil apoptotic process7595060
GO:0001878IEA-response to yeast-
GO:0002384IDA-hepatic immune response2444978
GO:0002384TAS-hepatic immune response12832423
GO:0002446TAS-neutrophil mediated immunity16034137
GO:0002548IC-monocyte chemotaxis10510402
GO:0002675IDA-positive regulation of acute inflammatory response2444978
GO:0002690TAS-positive regulation of leukocyte chemotaxis16034137
GO:0006469IEA-negative regulation of protein kinase activity-
GO:0006953TAS-acute-phase response12832423
GO:0006954IDA-inflammatory response10443688
GO:0006959IC-humoral immune response3491322
GO:0007568IEA-aging-
GO:0008284IDA-positive regulation of cell proliferation2261637
GO:0008284IMP-positive regulation of cell proliferation18719127
GO:0008285IEA-negative regulation of cell proliferation-
GO:0008360IEA-regulation of cell shape-
GO:0009408IEA-response to heat-
GO:0009409IEA-response to cold-
GO:0010574IDA-regulation of vascular endothelial growth factor production8557680
GO:0010628IDA-positive regulation of gene expression19390056
GO:0010888NAS-negative regulation of lipid storage16464856
GO:0010976IEA-positive regulation of neuron projection development-
GO:0010996IEA-response to auditory stimulus-
GO:0016049IEA-cell growth-
GO:0019221IDA-cytokine-mediated signaling pathway2261637
GO:0030168TAS-platelet activation7831669
GO:0031000IEA-response to caffeine-
GO:0031018ISS-endocrine pancreas development-
GO:0031175IMP-neuron projection development3264880
GO:0031294IEA-lymphocyte costimulation-
GO:0031669IEA-cellular response to nutrient levels-
GO:0032494NAS-response to peptidoglycan16034137
GO:0032722IDA-positive regulation of chemokine production10510402
GO:0032722NAS-positive regulation of chemokine production16034137
GO:0032755IDA-positive regulation of interleukin-6 production10510402
GO:0032868IEA-response to insulin-
GO:0032966IDA-negative regulation of collagen biosynthetic process12419823
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation7508917
GO:0033160IEA-positive regulation of protein import into nucleus, translocation-
GO:0035729IEA-cellular response to hepatocyte growth factor stimulus-
GO:0042102IDA-positive regulation of T cell proliferation3130269
GO:0042493IEA-response to drug-
GO:0042531IDA-positive regulation of tyrosine phosphorylation of STAT protein12643274
GO:0042593IEA-glucose homeostasis-
GO:0042832IEA-defense response to protozoan-
GO:0043065IDA-positive regulation of apoptotic process9949178
GO:0043066IDA-negative regulation of apoptotic process7595060
GO:0043154IEA-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0043200IEA-response to amino acid-
GO:0043410IDA-positive regulation of MAPK cascade7508917
GO:0043687TAS-post-translational protein modification-
GO:0044267TAS-cellular protein metabolic process-
GO:0045079ISS-negative regulation of chemokine biosynthetic process-
GO:0045188IEA-regulation of circadian sleep/wake cycle, non-REM sleep-
GO:0045429IEA-positive regulation of nitric oxide biosynthetic process-
GO:0045454IEA-cell redox homeostasis-
GO:0045599NAS-negative regulation of fat cell differentiation16464856
GO:0045630IEA-positive regulation of T-helper 2 cell differentiation-
GO:0045669TAS-positive regulation of osteoblast differentiation12372336
GO:0045721IEA-negative regulation of gluconeogenesis-
GO:0045727IDA-positive regulation of translation16732314
GO:0045740IEA-positive regulation of DNA replication-
GO:0045765IC-regulation of angiogenesis8557680
GO:0045779ISS-negative regulation of bone resorption-
GO:0045837IEA-negative regulation of membrane potential-
GO:0045893IDA-positive regulation of transcription, DNA-templated7749983
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter7508917
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0046427IDA-positive regulation of JAK-STAT cascade12419823
GO:0046677IEA-response to antibiotic-
GO:0046716IEA-muscle cell cellular homeostasis-
GO:0046849IEA-bone remodeling-
GO:0046888IEA-negative regulation of hormone secretion-
GO:0048635IEA-negative regulation of muscle organ development-
GO:0048661IDA-positive regulation of smooth muscle cell proliferation10510402
GO:0050679IEA-positive regulation of epithelial cell proliferation-
GO:0050710IEA-negative regulation of cytokine secretion-
GO:0050731IDA-positive regulation of peptidyl-tyrosine phosphorylation7508917
GO:0050829TAS-defense response to Gram-negative bacterium16034137
GO:0050830TAS-defense response to Gram-positive bacterium16034137
GO:0050871IDA-positive regulation of B cell activation3491322
GO:0051024IDA-positive regulation of immunoglobulin secretion3491322
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity7749983
GO:0051092IDANOTpositive regulation of NF-kappaB transcription factor activity12419823
GO:0051384IDA-response to glucocorticoid10443688
GO:0051592IEA-response to calcium ion-
GO:0051602IEA-response to electrical stimulus-
GO:0051607IDA-defense response to virus3023045
GO:0051897IEA-positive regulation of protein kinase B signaling-
GO:0051971IEA-positive regulation of transmission of nerve impulse-
GO:0060445IEA-branching involved in salivary gland morphogenesis-
GO:0060664IEA-epithelial cell proliferation involved in salivary gland morphogenesis-
GO:0070091ISS-glucagon secretion-
GO:0070102IDA-interleukin-6-mediated signaling pathway12552091
GO:0070301IDA-cellular response to hydrogen peroxide19168699
GO:0070374IEA-positive regulation of ERK1 and ERK2 cascade-
GO:0071222IMP-cellular response to lipopolysaccharide23776175
GO:0071347IEA-cellular response to interleukin-1-
GO:0071356IEA-cellular response to tumor necrosis factor-
GO:0071392IEA-cellular response to estradiol stimulus-
GO:0071549IEA-cellular response to dexamethasone stimulus-
GO:0071864IEA-positive regulation of cell proliferation in bone marrow-
GO:0072540ISS-T-helper 17 cell lineage commitment-
GO:1901215IEA-negative regulation of neuron death-
GO:1990646IEA-cellular response to prolactin-
GO:2000366IC-positive regulation of STAT protein import into nucleus17324931
GO:2000553ISS-positive regulation of T-helper 2 cell cytokine production-
GO:2000660ISS-negative regulation of interleukin-1-mediated signaling pathway-
GO:2000676TAS-positive regulation of type B pancreatic cell apoptotic process18719127
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
IL6RIL61097832788034 12643274 14557255 Affinity Capture-Western; Reconstituted Complex
IL6RIL61097842788034 12643274 14557255 Affinity Capture-Western; Reconstituted Complex
SH3GL2IL611235316169070 Two-hybrid
SH3GL2IL610978316169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
IL6IL6_C-572G, IL6_VNTR, rs1800795, rs1800796, rs2069837 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
IL6rs13447446, rs1800795 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
IL6IL6_SNP1, IL6_SNP2, rs1800795 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:96559
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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