AutismKB 2.0

Annotation Details for IL6ST


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Basic Information Top
Gene Symbol:IL6ST ( CD130,CDW130,DKFZp564F053,GP130,IL-6RB )
Gene Full Name: interleukin 6 signal transducer (gp130, oncostatin M receptor)
Band: 5q11.2
Quick LinksEntrez ID:3572; OMIM: 600694; Uniprot ID:IL6RB_HUMAN; ENSEMBL ID: ENSG00000134352; HGNC ID: 6021
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005886TAS-plasma membrane-
GO:0005896IDA-interleukin-6 receptor complex2261637
GO:0005900IDA-oncostatin-M receptor complex8999038
GO:0009897IEA-external side of plasma membrane-
GO:0016020IDA-membrane19946888
GO:0030425IEA-dendrite-
GO:0043025IEA-neuronal cell body-
GO:0070062IDA-extracellular exosome23376485
GO:0070110IDA-ciliary neurotrophic factor receptor complex12707266
GO ID Evidence Qualifier GO_term References
GO:0004897IDA-ciliary neurotrophic factor receptor activity12643274
GO:0004915IDAcontributes_tointerleukin-6 receptor activity2261637
GO:0004921IEA-interleukin-11 receptor activity-
GO:0004923IDAcontributes_toleukemia inhibitory factor receptor activity8999038
GO:0004924IDAcontributes_tooncostatin-M receptor activity8999038
GO:0005127IPI-ciliary neurotrophic factor receptor binding12707266
GO:0005138IPIcontributes_tointerleukin-6 receptor binding12829785
GO:0005515IPI-protein binding8662591
GO:0019838IPI-growth factor binding8999038
GO:0019838IPIcontributes_togrowth factor binding8999038
GO:0019970IEA-interleukin-11 binding-
GO:0019981IPIcontributes_tointerleukin-6 binding12829785
GO:0042803TAS-protein homodimerization activity8390097
GO:0045509IC-interleukin-27 receptor activity14764690
GO ID Evidence Qualifier GO_term References
GO:0002675IC-positive regulation of acute inflammatory response8999038
GO:0002821IC-positive regulation of adaptive immune response14764690
GO:0005977IEA-glycogen metabolic process-
GO:0008284IDA-positive regulation of cell proliferation2261637
GO:0008284IGI-positive regulation of cell proliferation8999038
GO:0008593IEA-regulation of Notch signaling pathway-
GO:0010575TAS-positive regulation of vascular endothelial growth factor production10744750
GO:0010613TAS-positive regulation of cardiac muscle hypertrophy10744750
GO:0016032IEA-viral process-
GO:0019221IDA-cytokine-mediated signaling pathway2261637
GO:0034097IDA-response to cytokine2261637
GO:0038154IEA-interleukin-11-mediated signaling pathway-
GO:0038165IMP-oncostatin-M-mediated signaling pathway8999038
GO:0042102IMP-positive regulation of T cell proliferation14764690
GO:0042531IMP-positive regulation of tyrosine phosphorylation of STAT protein14764690
GO:0043066TAS-negative regulation of apoptotic process17530315
GO:0045669IMP-positive regulation of osteoblast differentiation12372336
GO:0048711IEA-positive regulation of astrocyte differentiation-
GO:0048861IDA-leukemia inhibitory factor signaling pathway8999038
GO:0070102IMP-interleukin-6-mediated signaling pathway2261637
GO:0070106IMP-interleukin-27-mediated signaling pathway14764690
GO:0070120IDA-ciliary neurotrophic factor-mediated signaling pathway12643274
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
IL6STAR10978615129430 Affinity Capture-Western
IL6STAR10686215129430 Affinity Capture-Western
IL6STCDK910745912386808 Reconstituted Complex
IL6STCDK910978612386808 Reconstituted Complex
IL6STCNTFR10767112707266 Affinity Capture-Western; Reconstituted Complex
IL6STCNTFR10978612707266 Affinity Capture-Western; Reconstituted Complex
IL6STERBB210837611821958 Affinity Capture-Western
IL6STERBB210978611821958 Affinity Capture-Western
IL6STERBB310978611821958 Affinity Capture-Western
IL6STERBB310837711821958 Affinity Capture-Western
IL6STGRB21091429013873 Affinity Capture-Western; Reconstituted Complex
IL6STGRB21097869013873 Affinity Capture-Western; Reconstituted Complex
IL6STHCK10978611689697 Affinity Capture-Western
IL6STHCK10930511689697 Affinity Capture-Western
IL6STIL6R1097842788034 Affinity Capture-Western
IL6STIL6R1097862788034 Affinity Capture-Western
LIFRIL6ST1101658999038 12047380 Affinity Capture-Western
LIFRIL6ST1097868999038 12047380 Affinity Capture-Western
OSMRIL6ST1146178999038 Affinity Capture-Western
OSMRIL6ST1097868999038 Affinity Capture-Western
VAV1IL6ST1132529013873 Reconstituted Complex
VAV1IL6ST1097869013873 Reconstituted Complex
SHC1IL6ST1123619126968 Affinity Capture-Western; Reconstituted Complex
SHC1IL6ST1097869126968 Affinity Capture-Western; Reconstituted Complex
JAK2IL6ST1099209388212 Affinity Capture-Western
JAK2IL6ST1097869388212 Affinity Capture-Western
PTPN11IL6ST1117459388212 10946280 12403768 Affinity Capture-Western
PTPN11IL6ST1097869388212 10946280 12403768 Affinity Capture-Western
TYK2IL6ST1131489388212 Affinity Capture-Western
TYK2IL6ST1097869388212 Affinity Capture-Western
JAK1IL6ST1099199388212 11468294 11742534 Affinity Capture-Western; Reconstituted Complex
JAK1IL6ST1097869388212 11468294 11742534 Affinity Capture-Western; Reconstituted Complex
PIK3R1IL6ST11131310579793 Affinity Capture-Western
PIK3R1IL6ST10978610579793 Affinity Capture-Western
PTPN6IL6ST11174210800945 Affinity Capture-Western
PTPN6IL6ST10978610800945 Affinity Capture-Western
TLE1IL6ST11294312030375 Affinity Capture-Western; Two-hybrid
TLE1IL6ST10978612030375 Affinity Capture-Western; Two-hybrid
PRKCDIL6ST11156612361954 Affinity Capture-Western
PRKCDIL6ST10978612361954 Affinity Capture-Western
STAT3IL6ST11265112361954 Affinity Capture-Western
STAT3IL6ST10978612361954 Affinity Capture-Western
SOCS3IL6ST10978612403768 Affinity Capture-Western; Reconstituted Complex
SOCS3IL6ST11448812403768 Affinity Capture-Western; Reconstituted Complex
UBCIL6ST11316418519587 Affinity Capture-Western
UBCIL6ST10978618519587 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96560
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080104-6'