AutismKB 2.0

Annotation Details for CXCL10


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Basic Information Top
Gene Symbol:CXCL10 ( C7,IFI10,INP10,IP-10,SCYB10,crg-2,gIP-10,mob-1 )
Gene Full Name: chemokine (C-X-C motif) ligand 10
Band: 4q21.1
Quick LinksEntrez ID:3627; OMIM: 147310; Uniprot ID:CXL10_HUMAN; ENSEMBL ID: ENSG00000169245; HGNC ID: 10637
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IDA-extracellular region20041150
GO:0005576TAS-extracellular region-
GO:0005615IBA-extracellular space-
GO:0009897IEA-external side of plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0005102TAS-receptor binding10201891
GO:0005515IPI-protein binding18275857
GO:0008009IDA-chemokine activity12782716
GO:0008201IMP-heparin binding18645041
GO:0008603TAS-cAMP-dependent protein kinase regulator activity10903763
GO:0048248IDA-CXCR3 chemokine receptor binding12782716
GO ID Evidence Qualifier GO_term References
GO:0006935IDA-chemotaxis12782716
GO:0006954IBA-inflammatory response-
GO:0006955IBA-immune response-
GO:0007165TAS-signal transduction10201891
GO:0007166TAS-cell surface receptor signaling pathway10903763
GO:0007186IMP-G-protein coupled receptor signaling pathway12782716
GO:0007267TAS-cell-cell signaling3925348
GO:0007517TAS-muscle organ development8798675
GO:0008015TAS-blood circulation8798675
GO:0008284IEA-positive regulation of cell proliferation-
GO:0009409IEA-response to cold-
GO:0010332IEA-response to gamma radiation-
GO:0010818IMP-T cell chemotaxis18645041
GO:0010819IDA-regulation of T cell chemotaxis8608232
GO:0010996IEA-response to auditory stimulus-
GO:0016525IEA-negative regulation of angiogenesis-
GO:0030816IDA-positive regulation of cAMP metabolic process12782716
GO:0033280IEA-response to vitamin D-
GO:0034605IEA-cellular response to heat-
GO:0042118IGI-endothelial cell activation19470579
GO:0042127IDA-regulation of cell proliferation12782716
GO:0043950IDA-positive regulation of cAMP-mediated signaling12782716
GO:0045662IEA-negative regulation of myoblast differentiation-
GO:0045859IEA-regulation of protein kinase activity-
GO:0045944TAS-positive regulation of transcription from RNA polymerase II promoter12782716
GO:0051281IDA-positive regulation of release of sequestered calcium ion into cytosol12782716
GO:0051607IEA-defense response to virus-
GO:0070098IMP-chemokine-mediated signaling pathway18645041
GO:0071222IMP-cellular response to lipopolysaccharide23776175
GO:0090026IDA-positive regulation of monocyte chemotaxis8608232
GO:1901509IDA-regulation of endothelial tube morphogenesis16484616
GO:1901740IEA-negative regulation of myoblast fusion-
GO:2000406IDA-positive regulation of T cell migration23620790
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CXCL10CXCR310909412782716 Reconstituted Complex
CXCL10CXCR310983912782716 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
CXCL10rs3921, rs8878 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1352450
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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