AutismKB 2.0

Annotation Details for INPP5D


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:INPP5D ( MGC104855,MGC142140,MGC142142,SHIP,SHIP1,SIP-145,hp51CN )
Gene Full Name: inositol polyphosphate-5-phosphatase, 145kDa
Band: 2q37.1
Quick LinksEntrez ID:3635; OMIM: 601582; Uniprot ID:SHIP1_HUMAN; ENSEMBL ID: ENSG00000168918; HGNC ID: 6079
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005856IEA-cytoskeleton-
GO:0005886IEA-plasma membrane-
GO:0045121IEA-membrane raft-
GO ID Evidence Qualifier GO_term References
GO:0004445IEA-inositol-polyphosphate 5-phosphatase activity-
GO:0005515IPI-protein binding9148918
GO:0016314TAS-phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity-
GO:0017124IEA-SH3 domain binding-
GO:0034485TAS-phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity-
GO:0051425IEA-PTB domain binding-
GO:0052659TAS-inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity-
GO ID Evidence Qualifier GO_term References
GO:0006661TAS-phosphatidylinositol biosynthetic process-
GO:0006796TAS-phosphate-containing compound metabolic process8769125
GO:0006915IEA-apoptotic process-
GO:0007165TAS-signal transduction8769125
GO:0008340IEA-determination of adult lifespan-
GO:0009968IEA-negative regulation of signal transduction-
GO:0016064IEA-immunoglobulin mediated immune response-
GO:0030889IEA-negative regulation of B cell proliferation-
GO:0035556IEA-intracellular signal transduction-
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043647TAS-inositol phosphate metabolic process-
GO:0045409IEA-negative regulation of interleukin-6 biosynthetic process-
GO:0045579IEA-positive regulation of B cell differentiation-
GO:0045648IEA-positive regulation of erythrocyte differentiation-
GO:0045656IEA-negative regulation of monocyte differentiation-
GO:0045659IEA-negative regulation of neutrophil differentiation-
GO:0045671IEA-negative regulation of osteoclast differentiation-
GO:0045779IEA-negative regulation of bone resorption-
GO:0046856IEA-phosphatidylinositol dephosphorylation-
GO:0050777IEA-negative regulation of immune response-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0050900TAS-leukocyte migration-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
INPP5DCD2210984710748054 Affinity Capture-Western
INPP5DCD2210737110748054 Affinity Capture-Western
INPP5DCRKL10984711443118 Affinity Capture-Western; Reconstituted Complex
INPP5DCRKL10778911443118 Affinity Capture-Western; Reconstituted Complex
INPP5DDAB210984711247302 Reconstituted Complex
INPP5DDAB210797111247302 Reconstituted Complex
INPP5DDOK110984710822173 11071635 Affinity Capture-Western; Reconstituted Complex
INPP5DDOK110813110822173 11071635 Affinity Capture-Western; Reconstituted Complex
INPP5DEPOR10984715644415 PCA
INPP5DEPOR10837115644415 PCA
INPP5DGRB21091428723348 Affinity Capture-Western; Protein-peptide
INPP5DGRB21098478723348 Affinity Capture-Western; Protein-peptide
INPP5DIL4R10984711714803 Reconstituted Complex
INPP5DIL4R10978011714803 Reconstituted Complex
SHC1INPP5D1098478643691 10194451 10822173 10900203 12024011 Affinity Capture-Western
SHC1INPP5D1123618643691 10194451 10822173 10900203 12024011 Affinity Capture-Western
PTPN11INPP5D1098479110989 Affinity Capture-Western
PTPN11INPP5D1117459110989 Affinity Capture-Western
PIK3R1INPP5D1098479918857 Affinity Capture-Western
PIK3R1INPP5D1113139918857 Affinity Capture-Western
SLAMF1INPP5D10984710229804 Affinity Capture-Western
SLAMF1INPP5D11239510229804 Affinity Capture-Western
PECAM1INPP5D11120110350061 Far Western; Reconstituted Complex
PECAM1INPP5D10984710350061 Far Western; Reconstituted Complex
DOK2INPP5D10984710822173 Affinity Capture-Western
DOK2INPP5D11450810822173 Affinity Capture-Western
KITINPP5D10984711071635 Reconstituted Complex
KITINPP5D11001511071635 Reconstituted Complex
PRKCDINPP5D11156612024011 Affinity Capture-Western
PRKCDINPP5D10984712024011 Affinity Capture-Western
LYNINPP5D10984712882960 Affinity Capture-Western; Reconstituted Complex
LYNINPP5D11024512882960 Affinity Capture-Western; Reconstituted Complex
TRIP10INPP5D10984719041431 Affinity Capture-MS
TRIP10INPP5D11473319041431 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
INPP5Drs14243, rs3890760, rs6720896, rs7581787, rs7584458, rs9247 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:107357
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved