AutismKB 2.0

Annotation Details for INSR


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Basic Information Top
Gene Symbol:INSR ( CD220,HHF5 )
Gene Full Name: insulin receptor
Band: 19p13.2
Quick LinksEntrez ID:3643; OMIM: 147670; Uniprot ID:INSR_HUMAN; ENSEMBL ID: ENSG00000171105; HGNC ID: 6091
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IC-plasma membrane6849137
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane9092559
GO:0005899IMP-insulin receptor complex15069075
GO:0005901IDA-caveola15182363
GO:0010008TAS-endosome membrane-
GO:0016020IDA-membrane8452530
GO:0043235IDA-receptor complex23382219
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0004713IDA-protein tyrosine kinase activity8496180
GO:0004713IMP-protein tyrosine kinase activity7537849
GO:0004716IDA-signal transducer, downstream of receptor, with protein tyrosine kinase activity6849137
GO:0005009IDA-insulin-activated receptor activity6849137
GO:0005159IDA-insulin-like growth factor receptor binding8452530
GO:0005515IPI-protein binding7493946
GO:0005524IDA-ATP binding6849137
GO:0005525IDA-GTP binding9092559
GO:0019904IPI-protein domain specific binding16246733
GO:0031994IPI-insulin-like growth factor I binding8452530
GO:0031995IPI-insulin-like growth factor II binding12138094
GO:0043548IPI-phosphatidylinositol 3-kinase binding7537849
GO:0043559IDA-insulin binding8440175
GO:0043559IPI-insulin binding8452530
GO:0043560IPI-insulin receptor substrate binding7493946
GO:0051425IPI-PTB domain binding7559478
GO ID Evidence Qualifier GO_term References
GO:0000187IMP-activation of MAPK activity17001305
GO:0001934IDA-positive regulation of protein phosphorylation7556070
GO:0003007IMP-heart morphogenesis7693131
GO:0005975IEA-carbohydrate metabolic process-
GO:0006355IMP-regulation of transcription, DNA-templated12881524
GO:0007186IDA-G-protein coupled receptor signaling pathway9092559
GO:0008284IC-positive regulation of cell proliferation11500939
GO:0008284IDA-positive regulation of cell proliferation17925406
GO:0008286IDA-insulin receptor signaling pathway6849137
GO:0008286TAS-insulin receptor signaling pathway-
GO:0008544IEA-epidermis development-
GO:0008584IEA-male gonad development-
GO:0018108IDA-peptidyl-tyrosine phosphorylation8496180
GO:0019087IMP-transformation of host cell by virus17001305
GO:0023014IEA-signal transduction by protein phosphorylation-
GO:0030238IEA-male sex determination-
GO:0030325IEA-adrenal gland development-
GO:0030335IMP-positive regulation of cell migration12138094
GO:0031017IEA-exocrine pancreas development-
GO:0032147IMP-activation of protein kinase activity9819385
GO:0032148IDA-activation of protein kinase B activity7556070
GO:0032869IDA-cellular response to insulin stimulus8440175
GO:0035556IEA-intracellular signal transduction-
GO:0038083IEA-peptidyl-tyrosine autophosphorylation-
GO:0042593IMP-glucose homeostasis7693131
GO:0043410IDA-positive regulation of MAPK cascade20455999
GO:0043410IMP-positive regulation of MAPK cascade11500939
GO:0045429IMP-positive regulation of nitric oxide biosynthetic process10747347
GO:0045725IDA-positive regulation of glycogen biosynthetic process17925406
GO:0045740IMP-positive regulation of DNA replication12138094
GO:0045821IMP-positive regulation of glycolytic process7693131
GO:0045840IMP-positive regulation of mitotic nuclear division11500939
GO:0045893IEA-positive regulation of transcription, DNA-templated-
GO:0045995IMP-regulation of embryonic development7693131
GO:0046326IDA-positive regulation of glucose import3518947
GO:0046326NAS-positive regulation of glucose import11001060
GO:0046777IDA-protein autophosphorylation6849137
GO:0046777IMP-protein autophosphorylation7537849
GO:0048639IMP-positive regulation of developmental growth7693131
GO:0051290IDA-protein heterotetramerization1898103
GO:0051446IEA-positive regulation of meiotic cell cycle-
GO:0051897IMP-positive regulation of protein kinase B signaling11500939
GO:0060267IDA-positive regulation of respiratory burst9092559
GO:0071363IEA-cellular response to growth factor stimulus-
GO:2000194IEA-regulation of female gonad development-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
INSRAHSG1098547906861 Reconstituted Complex
INSRAHSG1067007906861 Reconstituted Complex
INSRCAV110730510598578 Affinity Capture-Western
INSRCAV110985410598578 Affinity Capture-Western
INSRCSK10783210026153 Two-hybrid
INSRCSK10985410026153 Two-hybrid
INSRGRB21091429083103 Affinity Capture-Western
INSRGRB21098549083103 Affinity Capture-Western
INSRGRB710914310803466 Reconstituted Complex; Two-hybrid
INSRGRB710985410803466 Reconstituted Complex; Two-hybrid
INSRGRB101098547479769 8621530 9006901 9506989 10871840 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
INSRGRB101091447479769 8621530 9006901 9506989 10871840 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
INSRGRB1410985411726652 Affinity Capture-Western
INSRGRB1410914511726652 Affinity Capture-Western
INSRHRAS1095013109943 Biochemical Activity
INSRHRAS1098543109943 Biochemical Activity
INSRINPPL110984812504111 Affinity Capture-Western
INSRINPPL110985412504111 Affinity Capture-Western
RASA1INSR1098541331107 Affinity Capture-Western
RASA1INSR1118561331107 Affinity Capture-Western
PTPN11INSR1098547493946 8135823 Affinity Capture-Western; Reconstituted Complex
PTPN11INSR1117457493946 8135823 Affinity Capture-Western; Reconstituted Complex
PTPN6INSR1117427512963 Affinity Capture-Western
PTPN6INSR1098547512963 Affinity Capture-Western
VAV1INSR1132527535775 Reconstituted Complex
VAV1INSR1098547535775 Reconstituted Complex
IRS1INSR1098548626379 11606564 Two-hybrid
IRS1INSR1098748626379 11606564 Two-hybrid
IRS2INSR1142098626379 Two-hybrid
IRS2INSR1098548626379 Two-hybrid
JAK2INSR1099208912646 Affinity Capture-Western
JAK2INSR1098548912646 Affinity Capture-Western
INSRRINSR1098548916919 Affinity Capture-Western
INSRRINSR1098568916919 Affinity Capture-Western
SMAD2INSR1098549092546 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SMAD2INSR1102629092546 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SH2B1INSR1098549742218 10594240 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SH2B1INSR1174559742218 10594240 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SNX1INSR1098549819414 Affinity Capture-Western
SNX1INSR1125259819414 Affinity Capture-Western
SNX2INSR1125269819414 Affinity Capture-Western
SNX2INSR1098549819414 Affinity Capture-Western
SNX4INSR1142629819414 Affinity Capture-Western
SNX4INSR1098549819414 Affinity Capture-Western
ENPP1INSR11119310615944 Affinity Capture-Western; Reconstituted Complex
ENPP1INSR10985410615944 Affinity Capture-Western; Reconstituted Complex
FRS2INSR10985410650943 Biochemical Activity
FRS2INSR11603110650943 Biochemical Activity
SHC1INSR10985410803466 Two-hybrid
SHC1INSR11236110803466 Two-hybrid
VAV3INSR11571511094073 Affinity Capture-Western
VAV3INSR10985411094073 Affinity Capture-Western
PRKCDINSR11156611266508 12031982 Affinity Capture-Western
PRKCDINSR10985411266508 12031982 Affinity Capture-Western
SNX6INSR10985411279102 Affinity Capture-Western
SNX6INSR12185211279102 Affinity Capture-Western
SORBS1INSR10985411374898 Affinity Capture-Western
SORBS1INSR11583111374898 Affinity Capture-Western
MAPK1INSR10985411409918 Affinity Capture-Western
MAPK1INSR11158011409918 Affinity Capture-Western
MAPK3INSR11158111409918 Affinity Capture-Western
MAPK3INSR10985411409918 Affinity Capture-Western
KHDRBS1INSR11590011604231 Affinity Capture-Western
KHDRBS1INSR10985411604231 Affinity Capture-Western
PTPN1INSR10985411726652 Affinity Capture-Western
PTPN1INSR11173611726652 Affinity Capture-Western
SYNCRIPINSR11575511994298 Biochemical Activity
SYNCRIPINSR10985411994298 Biochemical Activity
SOCS3INSR11448812560330 Affinity Capture-Western
SOCS3INSR10985412560330 Affinity Capture-Western
UBCINSR10985416434550 Affinity Capture-Western
UBCINSR11316416434550 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
INSRHMGA131427215924147 HMGA1 interacts with INSR locus.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
INSRrs1051690, rs1799817, rs2059806, rs2860177, rs2860178, rs2962 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:96575
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-020503-3'