AutismKB 2.0

Annotation Details for INSRR


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Basic Information Top
Gene Symbol:INSRR ( IRR )
Gene Full Name: insulin receptor-related receptor
Band: 1q23.1
Quick LinksEntrez ID:3645; OMIM: 147671; Uniprot ID:INSRR_HUMAN; ENSEMBL ID: ENSG00000027644; HGNC ID: 6093
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005887NAS-integral component of plasma membrane10226785
GO:0043235IDA-receptor complex23382219
GO ID Evidence Qualifier GO_term References
GO:0004714IDA-transmembrane receptor protein tyrosine kinase activity21641549
GO:0004714NAS-transmembrane receptor protein tyrosine kinase activity10226785
GO:0005524IEA-ATP binding-
GO:0043548IEA-phosphatidylinositol 3-kinase binding-
GO:0043560IEA-insulin receptor substrate binding-
GO ID Evidence Qualifier GO_term References
GO:0007169NAS-transmembrane receptor protein tyrosine kinase signaling pathway10226785
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0030238IEA-male sex determination-
GO:0031532IDA-actin cytoskeleton reorganization21641549
GO:0046777IMP-protein autophosphorylation21641549
GO:0071469IDA-cellular response to alkaline pH21641549
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
INSRRINSR1098548916919 Affinity Capture-Western
INSRRINSR1098568916919 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346037
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018