AutismKB 2.0

Annotation Details for ITGA6


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Basic Information Top
Gene Symbol:ITGA6 ( CD49f,DKFZp686J01244,FLJ18737,ITGA6B,VLA-6 )
Gene Full Name: integrin, alpha 6
Band: 2q31.1
Quick LinksEntrez ID:3655; OMIM: 147556; Uniprot ID:ITA6_HUMAN; ENSEMBL ID: ENSG00000091409; HGNC ID: 6142
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005604IEA-basement membrane-
GO:0005886IDA-plasma membrane21310825
GO:0005886TAS-plasma membrane-
GO:0005913IEA-cell-cell adherens junction-
GO:0005925IDA-focal adhesion21423176
GO:0009897IEA-external side of plasma membrane-
GO:0009925IEA-basal plasma membrane-
GO:0009986IDA-cell surface19933311
GO:0030056IEA-hemidesmosome-
GO:0030175IEA-filopodium-
GO:0034676IEA-integrin alpha6-beta4 complex-
GO ID Evidence Qualifier GO_term References
GO:0005178IEA-integrin binding-
GO:0005515IPI-protein binding2649503
GO:0031994IDAcontributes_toinsulin-like growth factor I binding22351760
GO:0038132IDAcontributes_toneuregulin binding20682778
GO:0043236IEA-laminin binding-
GO:0045296IDA-cadherin binding25468996
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0007044TAS-cell-substrate junction assembly9185503
GO:0007160IEA-cell-matrix adhesion-
GO:0007229IEA-integrin-mediated signaling pathway-
GO:0010668IEP-ectodermal cell differentiation23154389
GO:0010811IEA-positive regulation of cell-substrate adhesion-
GO:0016337IEA-single organismal cell-cell adhesion-
GO:0022409IEA-positive regulation of cell-cell adhesion-
GO:0030198TAS-extracellular matrix organization-
GO:0030335IMP-positive regulation of cell migration24091622
GO:0031581TAS-hemidesmosome assembly-
GO:0031589IMP-cell-substrate adhesion19933311
GO:0031668IEA-cellular response to extracellular stimulus-
GO:0033627IEA-cell adhesion mediated by integrin-
GO:0035878IMP-nail development23496044
GO:0042327IMP-positive regulation of phosphorylation21310825
GO:0043065IGI-positive regulation of apoptotic process19364818
GO:0043547IMP-positive regulation of GTPase activity25911094
GO:0043588IMP-skin development23496044
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter21310825
GO:0046847IEA-filopodium assembly-
GO:0048565IMP-digestive tract development23496044
GO:0050873IEA-brown fat cell differentiation-
GO:0050900TAS-leukocyte migration-
GO:0071407IEA-cellular response to organic cyclic compound-
GO:0072001IMP-renal system development23496044
GO:0097186IMP-amelogenesis23496044
GO:2001237IMP-negative regulation of extrinsic apoptotic signaling pathway21310825
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGA6BIN110986410094488 Two-hybrid
ITGA6BIN110677110094488 Two-hybrid
ITGA6CD3610986411238109 Affinity Capture-Western
ITGA6CD3610738611238109 Affinity Capture-Western
TSPAN4ITGA61129619360996 Affinity Capture-Western
TSPAN4ITGA61098649360996 Affinity Capture-Western
ITGB1ITGA61098649660880 Affinity Capture-Western
ITGB1ITGA61098949660880 Affinity Capture-Western
RABIFITGA610986410094488 Two-hybrid
RABIFITGA611181510094488 Two-hybrid
GIPC1ITGA611597811479315 Reconstituted Complex; Two-hybrid
GIPC1ITGA610986411479315 Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96605
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050309-23'