Annotation Details for IRAK2

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	IRAK2 ( IRAK-2,MGC150550 )
Gene Full Name:	interleukin-1 receptor-associated kinase 2
Band:	3p25.3
Quick Links	Entrez ID:3656; OMIM: 603304; Uniprot ID:IRAK2_HUMAN; ENSEMBL ID: ENSG00000134070; HGNC ID: 6113
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:5 results
Molecular Function:5 results
Biological Process:18 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IBA	-	nucleus	-
GO:0005737	IBA	-	cytoplasm	-
GO:0005829	TAS	-	cytosol	-
GO:0005886	TAS	-	plasma membrane	-
GO:0010008	TAS	-	endosome membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0004674	IBA	-	protein serine/threonine kinase activity	-
GO:0005515	IPI	-	protein binding	11544529
GO:0005524	IEA	-	ATP binding	-
GO:0042803	IPI	-	protein homodimerization activity	10383454
GO:0046982	IPI	-	protein heterodimerization activity	10383454

GO ID	Evidence	Qualifier	GO_term	References
GO:0000187	TAS	-	activation of MAPK activity	-
GO:0001959	IMP	-	regulation of cytokine-mediated signaling pathway	10383454
GO:0002224	TAS	-	toll-like receptor signaling pathway	-
GO:0002755	TAS	-	MyD88-dependent toll-like receptor signaling pathway	10383454
GO:0002756	TAS	-	MyD88-independent toll-like receptor signaling pathway	-
GO:0006468	TAS	-	protein phosphorylation	9374458
GO:0006954	IEA	-	inflammatory response	-
GO:0007249	TAS	-	I-kappaB kinase/NF-kappaB signaling	-
GO:0007254	TAS	-	JNK cascade	-
GO:0031663	IEA	-	lipopolysaccharide-mediated signaling pathway	-
GO:0032088	IMP	-	negative regulation of NF-kappaB transcription factor activity	10383454
GO:0034162	TAS	-	toll-like receptor 9 signaling pathway	-
GO:0035556	IBA	-	intracellular signal transduction	-
GO:0051092	IMP	-	positive regulation of NF-kappaB transcription factor activity	10383454
GO:0051092	TAS	-	positive regulation of NF-kappaB transcription factor activity	-
GO:0070423	TAS	-	nucleotide-binding oligomerization domain containing signaling pathway	-
GO:0070498	IMP	-	interleukin-1-mediated signaling pathway	10383454
GO:0070555	IMP	-	response to interleukin-1	10383454

Protein-Protein Interaction

BioGRID:16 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
IRAK2	IL1R1	109865	9374458	Affinity Capture-Western
IRAK2	IL1R1	109770	9374458	Affinity Capture-Western
TRAF6	IRAK2	113041	9374458 10383454 17878161	Affinity Capture-Western
TRAF6	IRAK2	109865	9374458 10383454 17878161	Affinity Capture-Western
MYD88	IRAK2	110700	9374458 10383454 11544529	Affinity Capture-Western; Phenotypic Suppression
MYD88	IRAK2	109865	9374458 10383454 11544529	Affinity Capture-Western; Phenotypic Suppression
TIRAP	IRAK2	125325	11544529	Affinity Capture-Western; Phenotypic Suppression
TIRAP	IRAK2	109865	11544529	Affinity Capture-Western; Phenotypic Suppression
PELI3	IRAK2	109865	17675297	Affinity Capture-Western
PELI3	IRAK2	128900	17675297	Affinity Capture-Western
PELI2	IRAK2	109865	17675297	Affinity Capture-Western
PELI2	IRAK2	121417	17675297	Affinity Capture-Western
PELI1	IRAK2	109865	17675297	Affinity Capture-Western
PELI1	IRAK2	121418	17675297	Affinity Capture-Western
TLR3	IRAK2	112953	17878161	Affinity Capture-Western
TLR3	IRAK2	109865	17878161	Affinity Capture-Western

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:1 results

MGI ID: MGI:2429603
Data Attributes: MGI curated and HomoloGene calculated