AutismKB 2.0

Annotation Details for IRS1


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Basic Information Top
Gene Symbol:IRS1 ( HIRS-1 )
Gene Full Name: insulin receptor substrate 1
Band: 2q36.3
Quick LinksEntrez ID:3667; OMIM: 147545; Uniprot ID:IRS1_HUMAN; ENSEMBL ID: ENSG00000169047; HGNC ID: 6125
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005737ISS-cytoplasm-
GO:0005829IBA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0005899ISS-insulin receptor complex-
GO:0005901IDA-caveola15182363
GO:0043231ISS-intracellular membrane-bounded organelle-
GO ID Evidence Qualifier GO_term References
GO:0001784IPI-phosphotyrosine residue binding20624904
GO:0004871TAS-signal transducer activity1311924
GO:0005068ISS-transmembrane receptor protein tyrosine kinase adaptor activity-
GO:0005080ISS-protein kinase C binding-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005158IPI-insulin receptor binding7493946
GO:0005159IPI-insulin-like growth factor receptor binding7541045
GO:0005515IPI-protein binding7513703
GO:0016303TAS-1-phosphatidylinositol-3-kinase activity-
GO:0042169ISS-SH2 domain binding-
GO:0043548IPI-phosphatidylinositol 3-kinase binding7782332
GO:0043548ISS-phosphatidylinositol 3-kinase binding-
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0007165TAS-signal transduction1311924
GO:0008284NAS-positive regulation of cell proliferation17925406
GO:0008286IDA-insulin receptor signaling pathway16516141
GO:0008286IMP-insulin receptor signaling pathway16814735
GO:0008286IPI-insulin receptor signaling pathway7537849
GO:0010907IMP-positive regulation of glucose metabolic process16814735
GO:0014065IDA-phosphatidylinositol 3-kinase signaling7782332
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0032000IMP-positive regulation of fatty acid beta-oxidation16814735
GO:0032868IDA-response to insulin16516141
GO:0032869IMP-cellular response to insulin stimulus16814735
GO:0036092IEA-phosphatidylinositol-3-phosphate biosynthetic process-
GO:0042593TAS-glucose homeostasis16814735
GO:0043434ISS-response to peptide hormone-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043552ISS-positive regulation of phosphatidylinositol 3-kinase activity-
GO:0045725IMP-positive regulation of glycogen biosynthetic process16814735
GO:0045725NAS-positive regulation of glycogen biosynthetic process17925406
GO:0046326IMP-positive regulation of glucose import16814735
GO:0046627ISS-negative regulation of insulin receptor signaling pathway-
GO:0046628ISS-positive regulation of insulin receptor signaling pathway-
GO:0046676IDA-negative regulation of insulin secretion15572028
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048009IPI-insulin-like growth factor receptor signaling pathway7541045
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:2001275IDA-positive regulation of glucose import in response to insulin stimulus7493946
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
IRS1AKT110987410497255 Affinity Capture-Western
IRS1AKT110671010497255 Affinity Capture-Western
IRS1ALK10673914968112 Affinity Capture-Western
IRS1ALK10987414968112 Affinity Capture-Western
IRS1BCL210987410679027 Affinity Capture-Western
IRS1BCL210706810679027 Affinity Capture-Western
IRS1BCL2L110987410679027 Affinity Capture-Western
IRS1BCL2L110707010679027 Affinity Capture-Western
IRS1CBLB10987416734387 Affinity Capture-Western
IRS1CBLB10731616734387 Affinity Capture-Western
IRS1CHUK10987412351658 Affinity Capture-Western
IRS1CHUK10756912351658 Affinity Capture-Western
IRS1AP3S11075909792713 Reconstituted Complex
IRS1AP3S11098749792713 Reconstituted Complex
IRS1ESR110840312821935 Affinity Capture-Western
IRS1ESR110987412821935 Affinity Capture-Western
IRS1MTOR10875711287630 Affinity Capture-Western
IRS1MTOR10987411287630 Affinity Capture-Western
IRS1SFN10907215778465 Affinity Capture-MS
IRS1SFN10987415778465 Affinity Capture-MS
IRS1GRB21091428491186 8536716 12173038 Affinity Capture-Western; Reconstituted Complex
IRS1GRB21098748491186 8536716 12173038 Affinity Capture-Western; Reconstituted Complex
IRS1GRB101098748621530 Reconstituted Complex
IRS1GRB101091448621530 Reconstituted Complex
IRS1HDAC210931615522123 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IRS1HDAC210987415522123 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IRS1IGF1R1097017559507 8776723 10082579 Affinity Capture-Western; Two-hybrid
IRS1IGF1R1098747559507 8776723 10082579 Affinity Capture-Western; Two-hybrid
IRS1IKBKB10976712351658 Affinity Capture-Western
IRS1IKBKB10987412351658 Affinity Capture-Western
IRS1INSR1098548626379 11606564 Two-hybrid
IRS1INSR1098748626379 11606564 Two-hybrid
PIK3R1IRS11098741381348 12107746 12173038 12730242 Affinity Capture-Western; Far Western
PIK3R1IRS11113131381348 12107746 12173038 12730242 Affinity Capture-Western; Far Western
SHC1IRS11098747499194 Reconstituted Complex
SHC1IRS11123617499194 Reconstituted Complex
JAK3IRS11099217499365 Affinity Capture-Western
JAK3IRS11098747499365 Affinity Capture-Western
JAK1IRS11099197499365 9492017 Affinity Capture-Western; Biochemical Activity
JAK1IRS11098747499365 9492017 Affinity Capture-Western; Biochemical Activity
PTPN11IRS11117458505282 9756938 Affinity Capture-Western; Reconstituted Complex
PTPN11IRS11098748505282 9756938 Affinity Capture-Western; Reconstituted Complex
YWHAEIRS11133639111084 Reconstituted Complex; Two-hybrid
YWHAEIRS11098749111084 Reconstituted Complex; Two-hybrid
PIK3R3IRS11140759415396 10417350 Affinity Capture-Western
PIK3R3IRS11098749415396 10417350 Affinity Capture-Western
YWHABIRS11133619422753 Reconstituted Complex
YWHABIRS11098749422753 Reconstituted Complex
JAK2IRS11099209492017 11208867 Affinity Capture-Western; Biochemical Activity
JAK2IRS11098749492017 11208867 Affinity Capture-Western; Biochemical Activity
PTK2IRS11117199822703 Affinity Capture-Western; Two-hybrid
PTK2IRS11098749822703 Affinity Capture-Western; Two-hybrid
NCK2IRS11140209843575 Reconstituted Complex
NCK2IRS11098749843575 Reconstituted Complex
PTPN1IRS111173610660596 11579209 Affinity Capture-Western; Reconstituted Complex
PTPN1IRS110987410660596 11579209 Affinity Capture-Western; Reconstituted Complex
MAPK8IRS111158510722755 11606564 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAPK8IRS110987410722755 11606564 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KHDRBS1IRS111590011604231 Affinity Capture-Western
KHDRBS1IRS110987411604231 Affinity Capture-Western
NISCHIRS111635811912194 Affinity Capture-Western
NISCHIRS110987411912194 Affinity Capture-Western
YWHAHIRS111336511969417 Affinity Capture-Western
YWHAHIRS110987411969417 Affinity Capture-Western
PRKCDIRS111156612031982 15516986 Affinity Capture-Western; Biochemical Activity
PRKCDIRS110987412031982 15516986 Affinity Capture-Western; Biochemical Activity
SOCS1IRS111420312228220 Affinity Capture-Western
SOCS1IRS110987412228220 Affinity Capture-Western
UBTFIRS111319012554758 Affinity Capture-Western
UBTFIRS110987412554758 Affinity Capture-Western
IRS2IRS111420912554758 Co-fractionation
IRS2IRS110987412554758 Co-fractionation
UBCIRS111316412821935 15516986 Affinity Capture-Western
UBCIRS110987412821935 15516986 Affinity Capture-Western
PIK3CAIRS110987416354680 Affinity Capture-Western
PIK3CAIRS111130816354680 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
IRS1rs1801123, rs2234931, rs2943634 Gene overview in AlzGene
No data
Gene Symbol Poly Names Gene overview in SZGene
IRS1rs1801123, rs1801278, rs4675096 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:99454
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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