AutismKB 2.0

Annotation Details for ISG20


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Basic Information Top
Gene Symbol:ISG20 ( CD25,HEM45 )
Gene Full Name: interferon stimulated exonuclease gene 20kDa
Band: 15q26.1
Quick LinksEntrez ID:3669; OMIM: 604533; Uniprot ID:ISG20_HUMAN; ENSEMBL ID: ENSG00000172183; HGNC ID: 6130
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus21036379
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus16514659
GO:0005737IDA-cytoplasm16514659
GO:0015030IDA-Cajal body16514659
GO:0016605IDA-PML body9235947
GO ID Evidence Qualifier GO_term References
GO:0000175IDA-3'-5'-exoribonuclease activity11401564
GO:0004527IMP-exonuclease activity21036379
GO:0008310IDA-single-stranded DNA 3'-5' exodeoxyribonuclease activity11401564
GO:0008859IEA-exoribonuclease II activity-
GO:0030619IDA-U1 snRNA binding16514659
GO:0030620IDA-U2 snRNA binding16514659
GO:0034511IDA-U3 snoRNA binding16514659
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000738IDA-DNA catabolic process, exonucleolytic11401564
GO:0006364IEA-rRNA processing-
GO:0006401IDA-RNA catabolic process11401564
GO:0008283TAS-cell proliferation9569007
GO:0009615IDA-response to virus12594219
GO:0045071IMP-negative regulation of viral genome replication21036379
GO:0051607IMP-defense response to virus21036379
GO:0060337TAS-type I interferon signaling pathway-
GO:0090503IEA-RNA phosphodiester bond hydrolysis, exonucleolytic-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1928895
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018