AutismKB 2.0

Annotation Details for ITGA2


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Basic Information Top
Gene Symbol:ITGA2 ( BR,CD49B,GPIa,VLA-2,VLAA2 )
Gene Full Name: integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Band: 5q11.2
Quick LinksEntrez ID:3673; OMIM: 192974; Uniprot ID:ITA2_HUMAN; ENSEMBL ID: ENSG00000164171; HGNC ID: 6137
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005886IDA-plasma membrane21310825
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion11518510
GO:0008305TAS-integrin complex2545729
GO:0009897IEA-external side of plasma membrane-
GO:0009986IDA-cell surface19581412
GO:0030424IEA-axon-
GO:0034666IDA-integrin alpha2-beta1 complex24823363
GO:0043679IEA-axon terminus-
GO:0045178IEA-basal part of cell-
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0001618IEA-virus receptor activity-
GO:0005178IEA-integrin binding-
GO:0005515IPI-protein binding7639691
GO:0005518IMP-collagen binding11518510
GO:0032403IPI-protein complex binding25336636
GO:0038064IMP-collagen receptor activity11518510
GO:0043236IEA-laminin binding-
GO:0046872IEA-metal ion binding-
GO:0046982IEA-protein heterodimerization activity-
GO:0098639IMP-collagen binding involved in cell-matrix adhesion24823363
GO ID Evidence Qualifier GO_term References
GO:0001666IEA-response to hypoxia-
GO:0002687IEA-positive regulation of leukocyte migration-
GO:0006929IMP-substrate-dependent cell migration11518510
GO:0006971IEA-hypotonic response-
GO:0007155TAS-cell adhesion10201960
GO:0007160IMP-cell-matrix adhesion11518510
GO:0007229IMP-integrin-mediated signaling pathway24823363
GO:0007565IEA-female pregnancy-
GO:0007596TAS-blood coagulation2933589
GO:0008283IEA-cell proliferation-
GO:0009887TAS-animal organ morphogenesis9391074
GO:0010634IEA-positive regulation of epithelial cell migration-
GO:0010694IEA-positive regulation of alkaline phosphatase activity-
GO:0014075IEA-response to amine-
GO:0014850IEA-response to muscle activity-
GO:0014911IEA-positive regulation of smooth muscle cell migration-
GO:0030198TAS-extracellular matrix organization-
GO:0030879IEA-mammary gland development-
GO:0031346IEA-positive regulation of cell projection organization-
GO:0031589IMP-cell-substrate adhesion19933311
GO:0032967IEA-positive regulation of collagen biosynthetic process-
GO:0033343IEA-positive regulation of collagen binding-
GO:0033591IEA-response to L-ascorbic acid-
GO:0033627IMP-cell adhesion mediated by integrin11518510
GO:0038065IMP-collagen-activated signaling pathway11518510
GO:0042493IEA-response to drug-
GO:0043388IEA-positive regulation of DNA binding-
GO:0043589IEA-skin morphogenesis-
GO:0045184IEA-establishment of protein localization-
GO:0045727IEA-positive regulation of translation-
GO:0045785IEA-positive regulation of cell adhesion-
GO:0045987IEA-positive regulation of smooth muscle contraction-
GO:0046718IEA-viral entry into host cell-
GO:0048041IEA-focal adhesion assembly-
GO:0048333IEP-mesodermal cell differentiation23154389
GO:0048661IEA-positive regulation of smooth muscle cell proliferation-
GO:0050729IEA-positive regulation of inflammatory response-
GO:0050927IEA-positive regulation of positive chemotaxis-
GO:0050966IEA-detection of mechanical stimulus involved in sensory perception of pain-
GO:0051971IEA-positive regulation of transmission of nerve impulse-
GO:0060100IEA-positive regulation of phagocytosis, engulfment-
GO:0070365IEA-hepatocyte differentiation-
GO:0071107IEA-response to parathyroid hormone-
GO:0071260IEA-cellular response to mechanical stimulus-
GO:0071392IEA-cellular response to estradiol stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGA2AUP110703112042322 Two-hybrid
ITGA2AUP110988012042322 Two-hybrid
ITGA2COL1A11076742156854 Co-purification
ITGA2COL1A11098802156854 Co-purification
LAMA1ITGA21297929688542 Reconstituted Complex
LAMA1ITGA21098809688542 Reconstituted Complex
RABIFITGA211181510094488 Two-hybrid
RABIFITGA210988010094488 Two-hybrid
CD46ITGA211034610741407 Affinity Capture-Western
CD46ITGA210988010741407 Affinity Capture-Western
MMP1ITGA211045611359774 11359786 Affinity Capture-Western; Reconstituted Complex
MMP1ITGA210988011359774 11359786 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96600
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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