AutismKB 2.0

Annotation Details for ITGA3


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Basic Information Top
Gene Symbol:ITGA3 ( CD49C,FLJ34631,FLJ34704,GAP-B3,GAPB3,MSK18,VCA-2,VL3A,VLA3a )
Gene Full Name: integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Band: 17q21.33
Quick LinksEntrez ID:3675; OMIM: 605025; Uniprot ID:ITA3_HUMAN; ENSEMBL ID: ENSG00000005884; HGNC ID: 6139
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane21310825
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0008305TAS-integrin complex1655803
GO:0009897IEA-external side of plasma membrane-
GO:0009986IDA-cell surface19581412
GO:0016323IEA-basolateral plasma membrane-
GO:0030426IEA-growth cone-
GO:0031527IDA-filopodium membrane10455171
GO:0034667IDA-integrin alpha3-beta1 complex25063885
GO:0034667IMP-integrin alpha3-beta1 complex24220332
GO:0043235IDA-receptor complex23382219
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0060076IEA-excitatory synapse-
GO:0070062IDA-extracellular exosome19056867
GO:0071438IDA-invadopodium membrane10455171
GO:0071944IDA-cell periphery24220332
GO:0097060IEA-synaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0001948IPI-glycoprotein binding24220332
GO:0001968IEA-fibronectin binding-
GO:0002020IPI-protease binding10455171
GO:0005178IEA-integrin binding-
GO:0005515IPI-protein binding1911778
GO:0005518IEA-collagen binding-
GO:0019904IEA-protein domain specific binding-
GO:0043236IEA-laminin binding-
GO:0046872IEA-metal ion binding-
GO:0046982IDA-protein heterodimerization activity10455171
GO ID Evidence Qualifier GO_term References
GO:0001764IEA-neuron migration-
GO:0007160TAS-cell-matrix adhesion1655803
GO:0007229IEA-integrin-mediated signaling pathway-
GO:0007507IEA-heart development-
GO:0007613IEA-memory-
GO:0010628IEA-positive regulation of gene expression-
GO:0010634IEA-positive regulation of epithelial cell migration-
GO:0010811IEA-positive regulation of cell-substrate adhesion-
GO:0010976IEA-positive regulation of neuron projection development-
GO:0017015IMP-regulation of transforming growth factor beta receptor signaling pathway24621570
GO:0030111IMP-regulation of Wnt signaling pathway24621570
GO:0030198TAS-extracellular matrix organization-
GO:0030324IMP-lung development24621570
GO:0030510IMP-regulation of BMP signaling pathway24621570
GO:0031345IEA-negative regulation of cell projection organization-
GO:0034698IEA-response to gonadotropin-
GO:0035024IEA-negative regulation of Rho protein signal transduction-
GO:0035640IEA-exploration behavior-
GO:0042493IEA-response to drug-
GO:0043588IMP-skin development24621570
GO:0048333IEP-mesodermal cell differentiation23154389
GO:0050900TAS-leukocyte migration-
GO:0060135IEA-maternal process involved in female pregnancy-
GO:0072006IMP-nephron development24621570
GO:0090004IDA-positive regulation of establishment of protein localization to plasma membrane10455171
GO:0097062IEA-dendritic spine maintenance-
GO:0097205IMP-renal filtration24621570
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGA3BIN110677110094488 Two-hybrid
ITGA3BIN110988210094488 Two-hybrid
ITGA3CD910736610065872 10694273 Affinity Capture-Western
ITGA3CD910988210065872 10694273 Affinity Capture-Western
ITGA3CD15110741510734060 Reconstituted Complex
ITGA3CD15110988210734060 Reconstituted Complex
ITGA3FHL210856510906324 Affinity Capture-Western; Two-hybrid
ITGA3FHL210988210906324 Affinity Capture-Western; Two-hybrid
TSPAN4ITGA31129619360996 Affinity Capture-Western
TSPAN4ITGA31098829360996 Affinity Capture-Western
RABIFITGA310988210094488 Two-hybrid
RABIFITGA311181510094488 Two-hybrid
LGALS8ITGA311015510852818 Affinity Capture-Western; Reconstituted Complex
LGALS8ITGA310988210852818 Affinity Capture-Western; Reconstituted Complex
ITGB1ITGA310989415254262 16878156 Affinity Capture-Western; Reconstituted Complex
ITGB1ITGA310988215254262 16878156 Affinity Capture-Western; Reconstituted Complex
ITGB4ITGA310988216878156 Affinity Capture-Western
ITGB4ITGA310989716878156 Affinity Capture-Western
ITGB5ITGA310989916878156 Affinity Capture-Western
ITGB5ITGA310988216878156 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
ITGA3rs4793637 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:96602
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050411-55'