Gene Symbol:	ITGA4 ( CD49D,IA4,MGC90518 )
Gene Full Name:	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Band:	2q31.3
Quick Links	Entrez ID:3676; OMIM: 192975; Uniprot ID:ITA4_HUMAN; ENSEMBL ID: ENSG00000115232; HGNC ID: 6140
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005886	IDA	-	plasma membrane	12869515
GO:0005886	TAS	-	plasma membrane	-
GO:0005925	IDA	-	focal adhesion	21423176
GO:0009986	IDA	-	cell surface	1715889
GO:0016020	IDA	-	membrane	19946888
GO:0034669	IDA	-	integrin alpha4-beta7 complex	18308860
GO:0070062	IDA	-	extracellular exosome	12519789

GO ID	Evidence	Qualifier	GO_term	References
GO:0001968	IEA	-	fibronectin binding	-
GO:0005515	IPI	-	protein binding	1542691
GO:0015026	TAS	-	coreceptor activity	23125415
GO:0019960	IDA	contributes_to	C-X3-C chemokine binding	23125415
GO:0046872	IEA	-	metal ion binding	-
GO:0050839	IMP	-	cell adhesion molecule binding	23986478
GO:0050839	IPI	-	cell adhesion molecule binding	12869515
GO:1990405	IEA	-	protein antigen binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0003366	IMP	-	cell-matrix adhesion involved in ameboidal cell migration	23986478
GO:0007159	IDA	-	leukocyte cell-cell adhesion	1715889
GO:0007160	IMP	-	cell-matrix adhesion	18308860
GO:0007229	IEA	-	integrin-mediated signaling pathway	-
GO:0030183	IC	-	B cell differentiation	1715889
GO:0030198	TAS	-	extracellular matrix organization	-
GO:0034113	IMP	-	heterotypic cell-cell adhesion	18308860
GO:0034446	IMP	-	substrate adhesion-dependent cell spreading	23986478
GO:0035987	IEP	-	endodermal cell differentiation	23154389
GO:0043113	IMP	-	receptor clustering	23986478
GO:0050776	TAS	-	regulation of immune response	-
GO:0050900	TAS	-	leukocyte migration	-
GO:0050901	IMP	-	leukocyte tethering or rolling	18308860
GO:0050904	IEA	-	diapedesis	-
GO:0071345	IEA	-	cellular response to cytokine stimulus	-
GO:0090074	IDA	-	negative regulation of protein homodimerization activity	12869515
GO:0098657	IEA	-	import into cell	-
GO:1903238	IEA	-	positive regulation of leukocyte tethering or rolling	-
GO:1990771	IEA	-	clathrin-dependent extracellular exosome endocytosis	-
GO:2000406	IEA	-	positive regulation of T cell migration	-

Gene Symbol	Interactant	Interaction ID	References	Description
ITGA4	CD81	109883	10229664	Affinity Capture-Western
ITGA4	CD81	107413	10229664	Affinity Capture-Western
EED	ITGA4	109883	9765275	Two-hybrid
EED	ITGA4	114265	9765275	Two-hybrid
LGALS8	ITGA4	110155	10852818	Affinity Capture-Western; Reconstituted Complex
LGALS8	ITGA4	109883	10852818	Affinity Capture-Western; Reconstituted Complex
PXN	ITGA4	111787	11533025 11919182	Reconstituted Complex
PXN	ITGA4	109883	11533025 11919182	Reconstituted Complex
PTK2	ITGA4	111719	11919182	Affinity Capture-Western
PTK2	ITGA4	109883	11919182	Affinity Capture-Western

AutismKB 2.0

Annotation Details for ITGA4