AutismKB 2.0

Annotation Details for ITGA5


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Basic Information Top
Gene Symbol:ITGA5 ( CD49e,FNRA,VLA5A )
Gene Full Name: integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
Band: 12q13.13
Quick LinksEntrez ID:3678; OMIM: 135620; Uniprot ID:ITA5_HUMAN; ENSEMBL ID: ENSG00000161638; HGNC ID: 6141
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726TAS-ruffle11919189
GO:0005783IEA-endoplasmic reticulum-
GO:0005794IEA-Golgi apparatus-
GO:0005886TAS-plasma membrane-
GO:0005911IDAcolocalizes_withcell-cell junction14970227
GO:0005925IDA-focal adhesion17158881
GO:0005925IDAcolocalizes_withfocal adhesion14970227
GO:0008305IEA-integrin complex-
GO:0009897IEA-external side of plasma membrane-
GO:0009986IDA-cell surface17158881
GO:0031410IEA-cytoplasmic vesicle-
GO:0032587IDAcolocalizes_withruffle membrane14970227
GO:0045202IEA-synapse-
GO:0071062TAS-alphav-beta3 integrin-vitronectin complex19267251
GO ID Evidence Qualifier GO_term References
GO:0001618IEA-virus receptor activity-
GO:0005154IEA-epidermal growth factor receptor binding-
GO:0005161TAS-platelet-derived growth factor receptor binding19267251
GO:0005178IEA-integrin binding-
GO:0005515IPI-protein binding12695522
GO:0043184TAS-vascular endothelial growth factor receptor 2 binding19267251
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001525TAS-angiogenesis19267251
GO:0007044IEA-cell-substrate junction assembly-
GO:0007155TAS-cell adhesion2454952
GO:0007157IEA-heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-
GO:0007159IEA-leukocyte cell-cell adhesion-
GO:0007229IEA-integrin-mediated signaling pathway-
GO:0007613IEA-memory-
GO:0010811IEA-positive regulation of cell-substrate adhesion-
GO:0030198TAS-extracellular matrix organization-
GO:0030335IEA-positive regulation of cell migration-
GO:0030949TAS-positive regulation of vascular endothelial growth factor receptor signaling pathway19267251
GO:0031589IMP-cell-substrate adhesion19933311
GO:0033627IDA-cell adhesion mediated by integrin12807887
GO:0033631IEA-cell-cell adhesion mediated by integrin-
GO:0034113IMP-heterotypic cell-cell adhesion20563599
GO:0035313IEP-wound healing, spreading of epidermal cells14970227
GO:0035987IMP-endodermal cell differentiation23154389
GO:0046718IEA-viral entry into host cell-
GO:0050731IMP-positive regulation of peptidyl-tyrosine phosphorylation10022831
GO:0050900TAS-leukocyte migration-
GO:1903672IMP-positive regulation of sprouting angiogenesis19460962
GO:2000811IMP-negative regulation of anoikis15006356
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGA5AUP110988412042322 Two-hybrid
ITGA5AUP110703112042322 Two-hybrid
ITGA5CBL10731515728256 Affinity Capture-Western
ITGA5CBL10988415728256 Affinity Capture-Western
ITGA5CD910988410065872 Affinity Capture-Western
ITGA5CD910736610065872 Affinity Capture-Western
ITGA5FGFR210988415728256 Affinity Capture-Western
ITGA5FGFR210855415728256 Affinity Capture-Western
ITGA5FN11098841532572 Reconstituted Complex
ITGA5FN11086211532572 Reconstituted Complex
ITGA5ILK1098248538749 Affinity Capture-Western
ITGA5ILK1098848538749 Affinity Capture-Western
SPP1ITGA51098847592829 Reconstituted Complex
SPP1ITGA51125747592829 Reconstituted Complex
RABIFITGA510988410094488 Two-hybrid
RABIFITGA511181510094488 Two-hybrid
L1CAMITGA510988410871287 Reconstituted Complex
L1CAMITGA511009410871287 Reconstituted Complex
GIPC1ITGA511597811479315 Reconstituted Complex; Two-hybrid
GIPC1ITGA510988411479315 Reconstituted Complex; Two-hybrid
UBCITGA510988415728256 Affinity Capture-Western
UBCITGA511316415728256 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96604
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-031116-52'