AutismKB 2.0

Annotation Details for ITGAL


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ITGAL ( CD11A,LFA-1,LFA1A )
Gene Full Name: integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Band: 16p11.2
Quick LinksEntrez ID:3683; OMIM: 153370; Uniprot ID:ITAL_HUMAN; ENSEMBL ID: ENSG00000005844; HGNC ID: 6148
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0008305NAS-integrin complex8103515
GO:0009986IDA-cell surface19029120
GO:0016020IDA-membrane19946888
GO:0034687IDA-integrin alphaL-beta2 complex19029120
GO:0035579TAS-specific granule membrane-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding11544294
GO:0030369IMP-ICAM-3 receptor activity19029120
GO:0032403IEA-protein complex binding-
GO:0046872IEA-metal ion binding-
GO:0046982IEA-protein heterodimerization activity-
GO:0050839IMP-cell adhesion molecule binding19029120
GO:0050839IPI-cell adhesion molecule binding1448173
GO ID Evidence Qualifier GO_term References
GO:0002291IMP-T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell2477710
GO:0006909IEA-phagocytosis-
GO:0006928TAS-movement of cell or subcellular component10477596
GO:0006954NAS-inflammatory response8103515
GO:0007155NAS-cell adhesion8103515
GO:0007157IMP-heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules2477710
GO:0007159IMP-leukocyte cell-cell adhesion2477710
GO:0007160IMP-cell-matrix adhesion19029120
GO:0007165NAS-signal transduction8103515
GO:0007229IEA-integrin-mediated signaling pathway-
GO:0030198TAS-extracellular matrix organization-
GO:0043113IMP-receptor clustering19029120
GO:0043312TAS-neutrophil degranulation-
GO:0050776TAS-regulation of immune response-
GO:0050900TAS-leukocyte migration-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGALICAM110988911279101 11786177 12526797 Co-crystal Structure; Reconstituted Complex
ITGALICAM110961011279101 11786177 12526797 Co-crystal Structure; Reconstituted Complex
ITGB2ITGAL1098959442085 Affinity Capture-Western
ITGB2ITGAL1098899442085 Affinity Capture-Western
CD82ITGAL10993510602019 Affinity Capture-Western
CD82ITGAL10988910602019 Affinity Capture-Western
ESM1ITGAL10988911544294 Affinity Capture-Western
ESM1ITGAL11626511544294 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96606
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved