AutismKB 2.0

Annotation Details for ITGAM


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Basic Information Top
Gene Symbol:ITGAM ( CD11B,CR3A,MAC-1,MAC1A,MGC117044,MO1A,SLEB6 )
Gene Full Name: integrin, alpha M (complement component 3 receptor 3 subunit)
Band: 16p11.2
Quick LinksEntrez ID:3684; OMIM: 120980; Uniprot ID:ITAM_HUMAN; ENSEMBL ID: ENSG00000169896; HGNC ID: 6149
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005615IDA-extracellular space25645918
GO:0005886TAS-plasma membrane-
GO:0008305IEA-integrin complex-
GO:0009986IDA-cell surface19234460
GO:0035579TAS-specific granule membrane-
GO:0070062IDA-extracellular exosome23376485
GO:0070821TAS-tertiary granule membrane-
GO ID Evidence Qualifier GO_term References
GO:0001948IPI-glycoprotein binding15004192
GO:0005515IPI-protein binding15194813
GO:0031072IPI-heat shock protein binding12496435
GO:0046872IEA-metal ion binding-
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0007155IEA-cell adhesion-
GO:0007229IEA-integrin-mediated signaling pathway-
GO:0010668IEP-ectodermal cell differentiation23154389
GO:0030198TAS-extracellular matrix organization-
GO:0034142TAS-toll-like receptor 4 signaling pathway-
GO:0043312TAS-neutrophil degranulation-
GO:0050900TAS-leukocyte migration-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGAMAUP110989012042322 Two-hybrid
ITGAMAUP110703112042322 Two-hybrid
ITGAMICAM110989012208882 Reconstituted Complex
ITGAMICAM110961012208882 Reconstituted Complex
ITGAMIRAK110986311701612 Affinity Capture-Western
ITGAMIRAK110989011701612 Affinity Capture-Western
PLAURITGAM10989010744708 Reconstituted Complex
PLAURITGAM11134510744708 Reconstituted Complex
JAM3ITGAM10989012208882 Reconstituted Complex
JAM3ITGAM12373412208882 Reconstituted Complex
PRTN3ITGAM10989012960243 Affinity Capture-Western
PRTN3ITGAM11163812960243 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96607
  • Data Attributes: HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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