AutismKB 2.0

Annotation Details for ITGAV


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ITGAV ( CD51,DKFZp686A08142,MSK8,VNRA )
Gene Full Name: integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
Band: 2q32.1
Quick LinksEntrez ID:3685; OMIM: 193210; Uniprot ID:ITAV_HUMAN; ENSEMBL ID: ENSG00000138448; HGNC ID: 6150
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829IDA-cytosol-
GO:0005886IDA-plasma membrane21310825
GO:0005886TAS-plasma membrane-
GO:0005887NAS-integral component of plasma membrane11877390
GO:0005925IDA-focal adhesion17158881
GO:0008305IDA-integrin complex15215180
GO:0008305NAS-integrin complex11877390
GO:0009897IEA-external side of plasma membrane-
GO:0009986IDA-cell surface1918072
GO:0009986ISS-cell surface-
GO:0016020ISS-membrane-
GO:0031258IDA-lamellipodium membrane25063885
GO:0031527IDA-filopodium membrane25063885
GO:0031528IDA-microvillus membrane25063885
GO:0032587IDA-ruffle membrane25063885
GO:0034683IDA-integrin alphav-beta3 complex22505472
GO:0034684IDA-integrin alphav-beta5 complex25063885
GO:0034685IEA-integrin alphav-beta6 complex-
GO:0034686IDA-integrin alphav-beta8 complex1918072
GO:0035579TAS-specific granule membrane-
GO:0035867IDA-alphav-beta3 integrin-IGF-1-IGF1R complex19578119
GO:0045335TAS-phagocytic vesicle-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0001618IEA-virus receptor activity-
GO:0001846ISScontributes_toopsonin binding-
GO:0001968IDA-fibronectin binding24658351
GO:0002020IDA-protease binding22505472
GO:0005080ISScontributes_toprotein kinase C binding-
GO:0005102IEA-receptor binding-
GO:0005245IDA-voltage-gated calcium channel activity18395422
GO:0005515IPI-protein binding1694173
GO:0015026TAS-coreceptor activity23125415
GO:0017134IDAcontributes_tofibroblast growth factor binding18441324
GO:0019960IDAcontributes_toC-X3-C chemokine binding23125415
GO:0031994IDAcontributes_toinsulin-like growth factor I binding19578119
GO:0038132IDAcontributes_toneuregulin binding20682778
GO:0042277IEA-peptide binding-
GO:0046872IEA-metal ion binding-
GO:0050431ISS-transforming growth factor beta binding-
GO:0050840IDA-extracellular matrix binding22505472
GO:1990430IDA-extracellular matrix protein binding7525578
GO ID Evidence Qualifier GO_term References
GO:0001525IEP-angiogenesis11866539
GO:0001570IEA-vasculogenesis-
GO:0002479TAS-antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-
GO:0007155IDA-cell adhesion10218736
GO:0007160IDA-cell-matrix adhesion22505472
GO:0007160IMP-cell-matrix adhesion7525578
GO:0007160NAS-cell-matrix adhesion11877390
GO:0007204IEA-positive regulation of cytosolic calcium ion concentration-
GO:0007229NAS-integrin-mediated signaling pathway11877390
GO:0008284IDA-positive regulation of cell proliferation19578119
GO:0010745IMP-negative regulation of macrophage derived foam cell differentiation15215180
GO:0010888IMP-negative regulation of lipid storage15215180
GO:0016049IMP-cell growth22505472
GO:0016477IMP-cell migration22505472
GO:0030198TAS-extracellular matrix organization-
GO:0030335IEA-positive regulation of cell migration-
GO:0031589IMP-cell-substrate adhesion19933311
GO:0032369IMP-negative regulation of lipid transport15215180
GO:0033627IDA-cell adhesion mediated by integrin12807887
GO:0033690IEA-positive regulation of osteoblast proliferation-
GO:0034113IMP-heterotypic cell-cell adhesion20563599
GO:0034446IDA-substrate adhesion-dependent cell spreading24658351
GO:0034765IEA-regulation of ion transmembrane transport-
GO:0035987IMP-endodermal cell differentiation23154389
GO:0038027IMP-apolipoprotein A-I-mediated signaling pathway23726972
GO:0038044IEA-transforming growth factor-beta secretion-
GO:0043277IEA-apoptotic cell clearance-
GO:0043312TAS-neutrophil degranulation-
GO:0043410IEA-positive regulation of MAPK cascade-
GO:0045715IMP-negative regulation of low-density lipoprotein particle receptor biosynthetic process15215180
GO:0045785IDA-positive regulation of cell adhesion10708943
GO:0046718IMP-viral entry into host cell25063885
GO:0046718TAS-viral entry into host cell10570297
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0050748IMP-negative regulation of lipoprotein metabolic process15215180
GO:0050764IDA-regulation of phagocytosis10570297
GO:0050900TAS-leukocyte migration-
GO:0050919IMP-negative chemotaxis23726972
GO:0052066NAS-entry of symbiont into host cell by promotion of host phagocytosis10570297
GO:0070371ISS-ERK1 and ERK2 cascade-
GO:0070588IDA-calcium ion transmembrane transport18395422
GO:0097192ISS-extrinsic apoptotic signaling pathway in absence of ligand-
GO:2000425ISS-regulation of apoptotic cell clearance-
GO:2000536IDA-negative regulation of entry of bacterium into host cell10570297
GO:2001237IMP-negative regulation of extrinsic apoptotic signaling pathway10708943
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGAVAUP110989112042322 Two-hybrid
ITGAVAUP110703112042322 Two-hybrid
ITGAVCYR6110989111287419 Reconstituted Complex
ITGAVCYR6110971211287419 Reconstituted Complex
L1CAMITGAV10989110871287 Reconstituted Complex
L1CAMITGAV11009410871287 Reconstituted Complex
ITGB3ITGAV10989611884718 Co-crystal Structure
ITGB3ITGAV10989111884718 Co-crystal Structure
NOVITGAV11091812902636 Reconstituted Complex
NOVITGAV10989112902636 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96608
  • Data Attributes: MGI curated and HomoloGene calculated
No data