AutismKB 2.0

Annotation Details for ITGAX


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Basic Information Top
Gene Symbol:ITGAX ( CD11C,SLEB6 )
Gene Full Name: integrin, alpha X (complement component 3 receptor 4 subunit)
Band: 16p11.2
Quick LinksEntrez ID:3687; OMIM: 151510; Uniprot ID:ITAX_HUMAN; ENSEMBL ID: ENSG00000140678; HGNC ID: 6152
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0008305IEA-integrin complex-
GO:0009986IC-cell surface20563599
GO:0009986IDA-cell surface19234460
GO:0016020IDA-membrane19946888
GO:0030667TAS-secretory granule membrane-
GO:0070821TAS-tertiary granule membrane-
GO:0101003TAS-ficolin-1-rich granule membrane-
GO ID Evidence Qualifier GO_term References
GO:0004872TAS-receptor activity2303426
GO:0005515IPI-protein binding17726152
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0007155TAS-cell adhesion2303426
GO:0007229IEA-integrin-mediated signaling pathway-
GO:0009887TAS-animal organ morphogenesis3327687
GO:0030198TAS-extracellular matrix organization-
GO:0034113IMP-heterotypic cell-cell adhesion20563599
GO:0043312TAS-neutrophil degranulation-
GO:0050900TAS-leukocyte migration-
GO:1903955IMP-positive regulation of protein targeting to mitochondrion24270810
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGAXC31071794062888 Reconstituted Complex
ITGAXC31098934062888 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96609
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018