AutismKB 2.0

Annotation Details for ITGB1


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Basic Information Top
Gene Symbol:ITGB1 ( CD29,FNRB,GPIIA,MDF2,MSK12,VLA-BETA,VLAB )
Gene Full Name: integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
Band: 10p11.22
Quick LinksEntrez ID:3688; OMIM: 135630; Uniprot ID:ITB1_HUMAN; ENSEMBL ID: ENSG00000150093; HGNC ID: 6153
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001726TAS-ruffle11919189
GO:0005737IDA-cytoplasm16803572
GO:0005886IDA-plasma membrane12869515
GO:0005886NAS-plasma membrane10455171
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion12417594
GO:0005925IDAcolocalizes_withfocal adhesion14970227
GO:0008305NAS-integrin complex9552005
GO:0009897IEA-external side of plasma membrane-
GO:0009986IDA-cell surface1715889
GO:0014704IEA-intercalated disc-
GO:0016020IDA-membrane19946888
GO:0030027IEA-lamellipodium-
GO:0030175IDA-filopodium16803572
GO:0031594IDA-neuromuscular junction9415431
GO:0032154IEA-cleavage furrow-
GO:0032587IDAcolocalizes_withruffle membrane14970227
GO:0032587NAS-ruffle membrane10455171
GO:0034665IDA-integrin alpha1-beta1 complex24823363
GO:0034666IDA-integrin alpha2-beta1 complex24823363
GO:0034667IDA-integrin alpha3-beta1 complex24220332
GO:0034677IEA-integrin alpha7-beta1 complex-
GO:0034678TAS-integrin alpha8-beta1 complex21335239
GO:0034680IDA-integrin alpha10-beta1 complex24823363
GO:0034681IDA-integrin alpha11-beta1 complex24823363
GO:0035748IEA-myelin sheath abaxonal region-
GO:0042383IDA-sarcolemma9415431
GO:0042470IEA-melanosome-
GO:0043197IEA-dendritic spine-
GO:0043235IDA-receptor complex23382219
GO:0045121IDA-membrane raft14559243
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0055037IEA-recycling endosome-
GO:0070062IDA-extracellular exosome19056867
GO:0071438IDA-invadopodium membrane10455171
GO:0097060IEA-synaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0001618IEA-virus receptor activity-
GO:0001968IPI-fibronectin binding11792823
GO:0002020IPI-protease binding10455171
GO:0003779IDA-actin binding16803572
GO:0005178IEA-integrin binding-
GO:0005515IPI-protein binding1542691
GO:0015026TAS-coreceptor activity23125415
GO:0019960IDAcontributes_toC-X3-C chemokine binding23125415
GO:0032403IPI-protein complex binding25336636
GO:0043236IEA-laminin binding-
GO:0045296IDA-cadherin binding25468996
GO:0046872IEA-metal ion binding-
GO:0046982IDA-protein heterodimerization activity10455171
GO:0046982NAS-protein heterodimerization activity9552005
GO:0050839IPI-cell adhesion molecule binding12869515
GO:0098639IMP-collagen binding involved in cell-matrix adhesion24823363
GO ID Evidence Qualifier GO_term References
GO:0000082IEA-G1/S transition of mitotic cell cycle-
GO:0001701IEA-in utero embryonic development-
GO:0001708IEA-cell fate specification-
GO:0002042IEA-cell migration involved in sprouting angiogenesis-
GO:0006968TAS-cellular defense response10201960
GO:0007156TAS-homophilic cell adhesion via plasma membrane adhesion molecules10201960
GO:0007159IDA-leukocyte cell-cell adhesion1715889
GO:0007160IMP-cell-matrix adhesion18156211
GO:0007161IGI-calcium-independent cell-matrix adhesion19651211
GO:0007179IMPNOTtransforming growth factor beta receptor signaling pathway24036928
GO:0007229IMP-integrin-mediated signaling pathway24823363
GO:0008284IEA-positive regulation of cell proliferation-
GO:0008354IEA-germ cell migration-
GO:0008542IEA-visual learning-
GO:0010710IDA-regulation of collagen catabolic process10455171
GO:0016477TAS-cell migration11919189
GO:0021943IEA-formation of radial glial scaffolds-
GO:0030183IC-B cell differentiation1715889
GO:0030198TAS-extracellular matrix organization-
GO:0031589IMP-cell-substrate adhesion19933311
GO:0031623ISS-receptor internalization-
GO:0033627IDA-cell adhesion mediated by integrin12807887
GO:0033631IEP-cell-cell adhesion mediated by integrin17704059
GO:0034113IMP-heterotypic cell-cell adhesion20563599
GO:0035024IEA-negative regulation of Rho protein signal transduction-
GO:0043065IGI-positive regulation of apoptotic process19364818
GO:0043149IMPNOTstress fiber assembly24036928
GO:0043547IMP-positive regulation of GTPase activity25911094
GO:0045214IEA-sarcomere organization-
GO:0045596IEA-negative regulation of cell differentiation-
GO:0046718IEA-viral entry into host cell-
GO:0048333IEP-mesodermal cell differentiation23154389
GO:0048675IEA-axon extension-
GO:0048813IEA-dendrite morphogenesis-
GO:0050776TAS-regulation of immune response-
GO:0050900TAS-leukocyte migration-
GO:0050901IMP-leukocyte tethering or rolling18308860
GO:0051726IEA-regulation of cell cycle-
GO:0055007IEA-cardiac muscle cell differentiation-
GO:0071404ISS-cellular response to low-density lipoprotein particle stimulus-
GO:0071711IEA-basement membrane organization-
GO:0090004IDA-positive regulation of establishment of protein localization to plasma membrane10455171
GO:2000811IMP-negative regulation of anoikis15006356
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGB1ACTN11098942116421 Reconstituted Complex
ITGB1ACTN11066022116421 Reconstituted Complex
ITGB1CANX1098948163531 Affinity Capture-Western
ITGB1CANX1072718163531 Affinity Capture-Western
ITGB1CD91098948630057 12175627 Affinity Capture-Western
ITGB1CD91073668630057 12175627 Affinity Capture-Western
ITGB1CD3610989411238109 Affinity Capture-Western
ITGB1CD3610738611238109 Affinity Capture-Western
ITGB1CD4710989410397731 Affinity Capture-Western
ITGB1CD4710739910397731 Affinity Capture-Western
ITGB1CD6310989412175627 Affinity Capture-Western
ITGB1CD6310740512175627 Affinity Capture-Western
ITGB1CD8110989410229664 12175627 Affinity Capture-Western
ITGB1CD8110741310229664 12175627 Affinity Capture-Western
ITGB1CD15110989412175627 Affinity Capture-Western
ITGB1CD15110741512175627 Affinity Capture-Western
ITGB1COL1A11098942156854 Co-purification
ITGB1COL1A11076742156854 Co-purification
ITGB1FHL210989410906324 Affinity Capture-Western; Two-hybrid
ITGB1FHL210856510906324 Affinity Capture-Western; Two-hybrid
ITGB1FLNA1086059722563 11807098 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ITGB1FLNA1098949722563 11807098 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ITGB1FLNB10989411807098 Reconstituted Complex; Two-hybrid
ITGB1FLNB10860611807098 Reconstituted Complex; Two-hybrid
ITGB1FLT410989411553610 Affinity Capture-Western
ITGB1FLT410861211553610 Affinity Capture-Western
ITGB1ILK1098248538749 Affinity Capture-Western
ITGB1ILK1098948538749 Affinity Capture-Western
ITGB1ITGA61098649660880 Affinity Capture-Western
ITGB1ITGA61098949660880 Affinity Capture-Western
ITGB1ITGA310989415254262 16878156 Affinity Capture-Western; Reconstituted Complex
ITGB1ITGA310988215254262 16878156 Affinity Capture-Western; Reconstituted Complex
ITGB1ITGA91098868245132 Affinity Capture-Western
ITGB1ITGA91098948245132 Affinity Capture-Western
ITGA8ITGB11140887768999 Affinity Capture-Western
ITGA8ITGB11098947768999 Affinity Capture-Western
ITGB1BP1ITGB11146899281591 11741908 Affinity Capture-Western; Reconstituted Complex
ITGB1BP1ITGB11098949281591 11741908 Affinity Capture-Western; Reconstituted Complex
TSPAN4ITGB11129619360996 Affinity Capture-Western
TSPAN4ITGB11098949360996 Affinity Capture-Western
GNB2L1ITGB11098949442085 12435334 Affinity Capture-Western
GNB2L1ITGB11156719442085 12435334 Affinity Capture-Western
ITGA10ITGB11140879685391 Affinity Capture-Western
ITGA10ITGB11098949685391 Affinity Capture-Western
LAMA1ITGB11098949688542 Reconstituted Complex
LAMA1ITGB11297929688542 Reconstituted Complex
CD46ITGB111034610741407 Affinity Capture-Western
CD46ITGB110989410741407 Affinity Capture-Western
PXNITGB111178710804218 Affinity Capture-Western
PXNITGB110989410804218 Affinity Capture-Western
LGALS8ITGB111015510852818 Affinity Capture-Western; Reconstituted Complex
LGALS8ITGB110989410852818 Affinity Capture-Western; Reconstituted Complex
TGOLN2ITGB110989411208159 Affinity Capture-Western
TGOLN2ITGB111586411208159 Affinity Capture-Western
TLN1ITGB111294911279249 Protein-peptide
TLN1ITGB110989411279249 Protein-peptide
YWHABITGB111336111313964 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YWHABITGB110989411313964 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NME1ITGB110989411919189 Affinity Capture-Western; Two-hybrid
NME1ITGB111089411919189 Affinity Capture-Western; Two-hybrid
MAP4K4ITGB111483811967148 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MAP4K4ITGB110989411967148 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PRKCAITGB110989412138200 12435334 Affinity Capture-Western
PRKCAITGB111156412138200 12435334 Affinity Capture-Western
FBXO2ITGB111762312140560 Affinity Capture-Western
FBXO2ITGB110989412140560 Affinity Capture-Western
SLC3A2ITGB111241112181350 Affinity Capture-Western
SLC3A2ITGB110989412181350 Affinity Capture-Western
RAB8BITGB110989412639940 Affinity Capture-Western
RAB8BITGB111971912639940 Affinity Capture-Western
VCPITGB110989415723043 Affinity Capture-Western
VCPITGB111325815723043 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
GNB2L1ITGB119482511884618 beta-1 integrin interacts with RACK1.
GNB2L1ITGB121658315611085 An unspecified isoform of integrin-beta-1 interacts with RACK1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96610
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030909-10'