AutismKB 2.0

Annotation Details for ITGB2


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Basic Information Top
Gene Symbol:ITGB2 ( CD18,LAD,LCAMB,LFA-1,MAC-1,MF17,MFI7 )
Gene Full Name: integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Band: 21q22.3
Quick LinksEntrez ID:3689; OMIM: 600065; Uniprot ID:ITB2_HUMAN; ENSEMBL ID: ENSG00000160255; HGNC ID: 6155
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886TAS-plasma membrane-
GO:0008305NAS-integrin complex12885943
GO:0009986IDA-cell surface19029120
GO:0016020IDA-membrane19946888
GO:0034687IDA-integrin alphaL-beta2 complex19029120
GO:0035579TAS-specific granule membrane-
GO:0043235IDA-receptor complex23382219
GO:0070062IDA-extracellular exosome20458337
GO:0070821TAS-tertiary granule membrane-
GO:0101003TAS-ficolin-1-rich granule membrane-
GO:1903561IDA-extracellular vesicle24769233
GO ID Evidence Qualifier GO_term References
GO:0001948IPI-glycoprotein binding16831868
GO:0005515IPI-protein binding17321526
GO:0019901IPI-protein kinase binding12885943
GO:0030369IMP-ICAM-3 receptor activity19029120
GO:0031072IPI-heat shock protein binding12496435
GO:0032403IEA-protein complex binding-
GO:0046872IEA-metal ion binding-
GO:0046982IEA-protein heterodimerization activity-
GO:0050839IMP-cell adhesion molecule binding19029120
GO ID Evidence Qualifier GO_term References
GO:0002523IEA-leukocyte migration involved in inflammatory response-
GO:0006909IEA-phagocytosis-
GO:0006915NAS-apoptotic process12885943
GO:0006954NAS-inflammatory response12885943
GO:0007155TAS-cell adhesion1694220
GO:0007159IDA-leukocyte cell-cell adhesion12885943
GO:0007160IMP-cell-matrix adhesion19029120
GO:0007229NAS-integrin-mediated signaling pathway12885943
GO:0007267NAS-cell-cell signaling12885943
GO:0007568IEA-aging-
GO:0008360NAS-regulation of cell shape12885943
GO:0030101IEA-natural killer cell activation-
GO:0030198TAS-extracellular matrix organization-
GO:0030593IDA-neutrophil chemotaxis12885943
GO:0031623ISS-receptor internalization-
GO:0034113IMP-heterotypic cell-cell adhesion20563599
GO:0034142TAS-toll-like receptor 4 signaling pathway-
GO:0035987IEP-endodermal cell differentiation23154389
GO:0043113IMP-receptor clustering19029120
GO:0043312TAS-neutrophil degranulation-
GO:0043542IEA-endothelial cell migration-
GO:0045123IEA-cellular extravasation-
GO:0045429IEA-positive regulation of nitric oxide biosynthetic process-
GO:0045766IEA-positive regulation of angiogenesis-
GO:0050730IDA-regulation of peptidyl-tyrosine phosphorylation12885943
GO:0050776TAS-regulation of immune response-
GO:0050900TAS-leukocyte migration-
GO:0051092IEA-positive regulation of NF-kappaB transcription factor activity-
GO:0071404ISS-cellular response to low-density lipoprotein particle stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGB2PTK2B10989510961871 Affinity Capture-Western
ITGB2PTK2B10848010961871 Affinity Capture-Western
ITGB2FHL210989510906324 Affinity Capture-Western; Two-hybrid
ITGB2FHL210856510906324 Affinity Capture-Western; Two-hybrid
ITGB2ICAM11098957642561 10352278 11279101 Reconstituted Complex
ITGB2ICAM11096107642561 10352278 11279101 Reconstituted Complex
ITGB2ITGAD1098958777714 Affinity Capture-Western
ITGB2ITGAD1098878777714 Affinity Capture-Western
ITGB2ITGAL1098959442085 Affinity Capture-Western
ITGB2ITGAL1098899442085 Affinity Capture-Western
GNB2L1ITGB21098959442085 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GNB2L1ITGB21156719442085 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CYTH1ITGB21146889765275 10835351 Reconstituted Complex; Two-hybrid
CYTH1ITGB21098959765275 10835351 Reconstituted Complex; Two-hybrid
PLAURITGB210989510388537 Affinity Capture-Western
PLAURITGB211134510388537 Affinity Capture-Western
CD226ITGB210989510591186 Affinity Capture-Western
CD226ITGB211590810591186 Affinity Capture-Western
KNG1ITGB210989510845911 Reconstituted Complex
KNG1ITGB211002610845911 Reconstituted Complex
SYKITGB210989510961871 Affinity Capture-Western
SYKITGB211271710961871 Affinity Capture-Western
VNN2ITGB211439412056825 Affinity Capture-Western
VNN2ITGB210989512056825 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
ITGB2rs2075884, rs2235133, rs2280965 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:96611
  • Data Attributes: MGI curated and HomoloGene calculated
No data