AutismKB 2.0

Annotation Details for ITGB3


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Basic Information Top
Gene Symbol:ITGB3 ( CD61,GP3A,GPIIIa )
Gene Full Name: integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Band: 17q21.32
Quick LinksEntrez ID:3690; OMIM: 173470; Uniprot ID:ITB3_HUMAN; ENSEMBL ID: ENSG00000056345; HGNC ID: 6156
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus22027834
GO:0005886IDA-plasma membrane15466936
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane2452834
GO:0005925IDA-focal adhesion21423176
GO:0008305IDA-integrin complex15215180
GO:0009986IDA-cell surface7525578
GO:0031092TAS-platelet alpha granule membrane-
GO:0031258IDA-lamellipodium membrane25063885
GO:0031527IDA-filopodium membrane25063885
GO:0031528IDA-microvillus membrane25063885
GO:0032587IDA-ruffle membrane25063885
GO:0034683IDA-integrin alphav-beta3 complex22505472
GO:0035867IDA-alphav-beta3 integrin-IGF-1-IGF1R complex19578119
GO:0042470IDA-melanosome15466936
GO:0043235IDA-receptor complex23382219
GO:0070062IDA-extracellular exosome20458337
GO:0071062TAS-alphav-beta3 integrin-vitronectin complex19267251
GO ID Evidence Qualifier GO_term References
GO:0001618IEA-virus receptor activity-
GO:0001968IMP-fibronectin binding24658351
GO:0002020IDA-protease binding22505472
GO:0003756IDA-protein disulfide isomerase activity12204115
GO:0005161TAS-platelet-derived growth factor receptor binding19267251
GO:0005515IPI-protein binding1694173
GO:0015026TAS-coreceptor activity23125415
GO:0017134IDAcontributes_tofibroblast growth factor binding18441324
GO:0019899IPI-enzyme binding21670307
GO:0019960IDAcontributes_toC-X3-C chemokine binding23125415
GO:0031994IDAcontributes_toinsulin-like growth factor I binding19578119
GO:0038132IDAcontributes_toneuregulin binding20682778
GO:0042802IPI-identical protein binding11606749
GO:0043184IPI-vascular endothelial growth factor receptor 2 binding10022831
GO:0043184TAS-vascular endothelial growth factor receptor 2 binding19267251
GO:0050839IPI-cell adhesion molecule binding8837777
GO:0050840IDA-extracellular matrix binding22505472
GO ID Evidence Qualifier GO_term References
GO:0001934TAS-positive regulation of protein phosphorylation19267251
GO:0001938IMP-positive regulation of endothelial cell proliferation10022831
GO:0002576TAS-platelet degranulation-
GO:0007044IEA-cell-substrate junction assembly-
GO:0007155TAS-cell adhesion2452834
GO:0007160IDA-cell-matrix adhesion22505472
GO:0007160IMP-cell-matrix adhesion7525578
GO:0007229IDA-integrin-mediated signaling pathway23382103
GO:0007229TAS-integrin-mediated signaling pathway21488147
GO:0007596TAS-blood coagulation1438206
GO:0010595IMP-positive regulation of endothelial cell migration10022831
GO:0010745IMP-negative regulation of macrophage derived foam cell differentiation15215180
GO:0010888IMP-negative regulation of lipid storage15215180
GO:0014909IMP-smooth muscle cell migration8837777
GO:0016049IMP-cell growth22505472
GO:0016477IMP-cell migration22505472
GO:0030168IMP-platelet activation15466936
GO:0030198TAS-extracellular matrix organization-
GO:0030949TAS-positive regulation of vascular endothelial growth factor receptor signaling pathway19267251
GO:0031589IMP-cell-substrate adhesion19933311
GO:0032147IMP-activation of protein kinase activity10022831
GO:0032369IMP-negative regulation of lipid transport15215180
GO:0033627IDA-cell adhesion mediated by integrin12807887
GO:0034113IMP-heterotypic cell-cell adhesion20563599
GO:0034446IDA-substrate adhesion-dependent cell spreading24658351
GO:0035295TAS-tube development19267251
GO:0038027IMP-apolipoprotein A-I-mediated signaling pathway23726972
GO:0042060IC-wound healing8837777
GO:0045124TAS-regulation of bone resorption19267251
GO:0045715IMP-negative regulation of low-density lipoprotein particle receptor biosynthetic process15215180
GO:0046718IMP-viral entry into host cell25063885
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048333IEP-mesodermal cell differentiation23154389
GO:0050731IMP-positive regulation of peptidyl-tyrosine phosphorylation10022831
GO:0050748IMP-negative regulation of lipoprotein metabolic process15215180
GO:0050900TAS-leukocyte migration-
GO:0050919IMP-negative chemotaxis23726972
GO:0060055TAS-angiogenesis involved in wound healing19267251
GO:0070527IMP-platelet aggregation15466936
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITGB3CD3610989611238109 Affinity Capture-Western
ITGB3CD3610738611238109 Affinity Capture-Western
ITGB3PTK2B10848011683411 Reconstituted Complex
ITGB3PTK2B10989611683411 Reconstituted Complex
ITGB3FLNA10860511807098 Two-hybrid
ITGB3FLNA10989611807098 Two-hybrid
ITGB3FLNB10989611807098 Two-hybrid
ITGB3FLNB10860611807098 Two-hybrid
ITGB3ILK10982412372433 Affinity Capture-Western
ITGB3ILK10989612372433 Affinity Capture-Western
ITGB3ITGAV10989611884718 Co-crystal Structure
ITGB3ITGAV10989111884718 Co-crystal Structure
THBS1ITGB31129152478219 Reconstituted Complex
THBS1ITGB31098962478219 Reconstituted Complex
ITGB3BPITGB31098967593198 11864709 Reconstituted Complex; Two-hybrid
ITGB3BPITGB31169927593198 11864709 Reconstituted Complex; Two-hybrid
CIB1ITGB31157749030514 Reconstituted Complex; Two-hybrid
CIB1ITGB31098969030514 Reconstituted Complex; Two-hybrid
PTK2ITGB31117199169439 11927607 Affinity Capture-Western; Reconstituted Complex
PTK2ITGB31098969169439 11927607 Affinity Capture-Western; Reconstituted Complex
TLN1ITGB311294910497223 11932255 Reconstituted Complex
TLN1ITGB310989610497223 11932255 Reconstituted Complex
PDGFRBITGB310989610964931 Affinity Capture-Western
PDGFRBITGB311118510964931 Affinity Capture-Western
PECAM1ITGB311120110982404 Co-localization
PECAM1ITGB310989610982404 Co-localization
PXNITGB311178711683411 Reconstituted Complex
PXNITGB310989611683411 Reconstituted Complex
PDGFRAITGB310989611953315 Affinity Capture-Western
PDGFRAITGB311118211953315 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
ITGB3rs2271803 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:96612
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-071207-1'