AutismKB 2.0

Annotation Details for ITK


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ITK ( EMT,LYK,MGC126257,MGC126258,PSCTK2 )
Gene Full Name: IL2-inducible T-cell kinase
Band: 5q33.3
Quick LinksEntrez ID:3702; OMIM: 186973; Uniprot ID:ITK_HUMAN; ENSEMBL ID: ENSG00000113263; HGNC ID: 6171
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO:0005911IEA-cell-cell junction-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0004715IDA-non-membrane spanning protein tyrosine kinase activity12186560
GO:0005102IBANOTreceptor binding-
GO:0005515IPI-protein binding8892607
GO:0005524IEA-ATP binding-
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001816ISS-cytokine production-
GO:0001865IBA-NK T cell differentiation-
GO:0002250ISS-adaptive immune response-
GO:0006968TAS-cellular defense response8364206
GO:0007165TAS-signal transduction8364206
GO:0007169IBA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0007202ISS-activation of phospholipase C activity-
GO:0032609IEA-interferon-gamma production-
GO:0032633IEA-interleukin-4 production-
GO:0035556IEA-intracellular signal transduction-
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0042110TAS-T cell activation12186560
GO:0042127IBA-regulation of cell proliferation-
GO:0045087IBA-innate immune response-
GO:0050852ISS-T cell receptor signaling pathway-
GO:0050852TAS-T cell receptor signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITKCBL1073158810341 Reconstituted Complex
ITKCBL1099078810341 Reconstituted Complex
ITKCD21099079677430 Affinity Capture-Western
ITKCD21073529677430 Affinity Capture-Western
ITKFYN1088108810341 10636929 Reconstituted Complex
ITKFYN1099078810341 10636929 Reconstituted Complex
ITKGRB21091428985255 10636929 Reconstituted Complex
ITKGRB21099078985255 10636929 Reconstituted Complex
ITKHNRNPK1094318810341 Reconstituted Complex
ITKHNRNPK1099078810341 Reconstituted Complex
KHDRBS1ITK1159008810341 8985255 12163161 Biochemical Activity; Reconstituted Complex
KHDRBS1ITK1099078810341 8985255 12163161 Biochemical Activity; Reconstituted Complex
WASITK1099078810341 8892607 Reconstituted Complex
WASITK1132938810341 8892607 Reconstituted Complex
SOCS1ITK11420310022833 Reconstituted Complex
SOCS1ITK10990710022833 Reconstituted Complex
LATITK11797110506192 12186560 Affinity Capture-Western; Biochemical Activity
LATITK10990710506192 12186560 Affinity Capture-Western; Biochemical Activity
PLCG1ITK10990710586033 12163161 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PLCG1ITK11135110586033 12163161 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
LCP2ITK10990710636929 15388330 Affinity Capture-Western; Reconstituted Complex
LCP2ITK11012910636929 15388330 Affinity Capture-Western; Reconstituted Complex
SRCITK10990710636929 Reconstituted Complex
SRCITK11259210636929 Reconstituted Complex
KPNA2ITK11003611581171 Affinity Capture-Western; Reconstituted Complex
KPNA2ITK10990711581171 Affinity Capture-Western; Reconstituted Complex
PPIAITK10990711830645 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure
PPIAITK11147411830645 Affinity Capture-Western; Biochemical Activity; Co-crystal Structure
ITKITK10990712163161 Biochemical Activity
IKBKGITK11408920098747 Reconstituted Complex
IKBKGITK10990720098747 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96621
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990415-261'