Annotation Details for ITPKB

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Basic Information Top

Gene Symbol:	ITPKB ( IP3-3KB,IP3K,IP3K-B,IP3KB,PIG37 )
Gene Full Name:	inositol 1,4,5-trisphosphate 3-kinase B
Band:	1q42.12
Quick Links	Entrez ID:3707; OMIM: 147522; Uniprot ID:IP3KB_HUMAN; ENSEMBL ID: ENSG00000143772; HGNC ID: 6179
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:3 results
Molecular Function:5 results
Biological Process:14 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IEA	-	nucleus	-
GO:0005829	TAS	-	cytosol	-
GO:0016020	IEA	-	membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0005515	IPI	-	protein binding	21516116
GO:0005516	IEA	-	calmodulin binding	-
GO:0005524	IEA	-	ATP binding	-
GO:0008440	IDA	-	inositol-1,4,5-trisphosphate 3-kinase activity	1654894
GO:0008440	TAS	-	inositol-1,4,5-trisphosphate 3-kinase activity	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000165	IEA	-	MAPK cascade	-
GO:0001932	IEA	-	regulation of protein phosphorylation	-
GO:0002262	IEA	-	myeloid cell homeostasis	-
GO:0007165	TAS	-	signal transduction	1654894
GO:0007166	IEA	-	cell surface receptor signaling pathway	-
GO:0032957	IDA	-	inositol trisphosphate metabolic process	1654894
GO:0033030	IEA	-	negative regulation of neutrophil apoptotic process	-
GO:0035726	IEA	-	common myeloid progenitor cell proliferation	-
GO:0043647	TAS	-	inositol phosphate metabolic process	-
GO:0045059	IEA	-	positive thymic T cell selection	-
GO:0045638	IEA	-	negative regulation of myeloid cell differentiation	-
GO:0046579	IEA	-	positive regulation of Ras protein signal transduction	-
GO:0046638	IEA	-	positive regulation of alpha-beta T cell differentiation	-
GO:0071277	IDA	-	cellular response to calcium ion	1654894

Protein-Protein Interaction

BioGRID:2 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
PSME3	ITPKB	109912	16189514	Two-hybrid
PSME3	ITPKB	115492	16189514	Two-hybrid

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:109235
Data Attributes: MGI curated and HomoloGene calculated

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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