AutismKB 2.0

Annotation Details for ITPR1


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Basic Information Top
Gene Symbol:ITPR1 ( DKFZp313E1334,DKFZp313N1434,INSP3R1,IP3R,IP3R1,SCA15,SCA16 )
Gene Full Name: inositol 1,4,5-triphosphate receptor, type 1
Band: 3p26.1
Quick LinksEntrez ID:3708; OMIM: 147265; Uniprot ID:ITPR1_HUMAN; ENSEMBL ID: ENSG00000150995; HGNC ID: 6180
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005637IEA-nuclear inner membrane-
GO:0005730IEA-nucleolus-
GO:0005783NAS-endoplasmic reticulum8648241
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005886IBA-plasma membrane-
GO:0005955IEA-calcineurin complex-
GO:0014069IEA-postsynaptic density-
GO:0016020IDA-membrane19946888
GO:0016021IEA-integral component of membrane-
GO:0016529IEA-sarcoplasmic reticulum-
GO:0030658IEA-transport vesicle membrane-
GO:0031088IDA-platelet dense granule membrane10828023
GO:0031094IDA-platelet dense tubular network10828023
GO:0031095TAS-platelet dense tubular network membrane-
GO:0043234IEA-protein complex-
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0005220ISS-inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity-
GO:0005220TAS-inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity8648241
GO:0005509IBA-calcium ion binding-
GO:0005515IPI-protein binding16793548
GO:0015085TAS-calcium ion transmembrane transporter activity7500840
GO:0015278ISS-calcium-release channel activity-
GO:0019855IDA-calcium channel inhibitor activity16793548
GO:0035091ISS-phosphatidylinositol binding-
GO ID Evidence Qualifier GO_term References
GO:0001666IDA-response to hypoxia19120137
GO:0006816NAS-calcium ion transport7852357
GO:0007165NAS-signal transduction8648241
GO:0009791IEA-post-embryonic development-
GO:0010506TAS-regulation of autophagy22770472
GO:0030168TAS-platelet activation-
GO:0032469IEA-endoplasmic reticulum calcium ion homeostasis-
GO:0042045IEA-epithelial fluid transport-
GO:0048016IEA-inositol phosphate-mediated signaling-
GO:0050796TAS-regulation of insulin secretion-
GO:0050849IDA-negative regulation of calcium-mediated signaling16793548
GO:0050882IEA-voluntary musculoskeletal movement-
GO:0051209ISS-release of sequestered calcium ion into cytosol-
GO:0065009IEA-regulation of molecular function-
GO:0070059ISS-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress-
GO:1903779TAS-regulation of cardiac conduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITPR1RHOA10688012766172 Affinity Capture-Western; Reconstituted Complex
ITPR1RHOA10991312766172 Affinity Capture-Western; Reconstituted Complex
ITPR1BCL210991315613488 Affinity Capture-Western
ITPR1BCL210706815613488 Affinity Capture-Western
ITPR1CA810722212611586 Reconstituted Complex; Two-hybrid
ITPR1CA810991312611586 Reconstituted Complex; Two-hybrid
ITPR1EPB41L110835012676536 Affinity Capture-Western; Two-hybrid
ITPR1EPB41L110991312676536 Affinity Capture-Western; Two-hybrid
ITPR1FKBP1A1085709346894 16278292 Affinity Capture-Western; Two-hybrid
ITPR1FKBP1A1099139346894 16278292 Affinity Capture-Western; Two-hybrid
ITPR3ITPR11099137559486 Co-fractionation
ITPR3ITPR11099157559486 Co-fractionation
MRVI1ITPR111561710724174 Affinity Capture-Western
MRVI1ITPR110991310724174 Affinity Capture-Western
PRKG1ITPR111157810724174 Affinity Capture-Western; Biochemical Activity
PRKG1ITPR110991310724174 Affinity Capture-Western; Biochemical Activity
TRPC4ITPR111307411163362 14505576 Affinity Capture-Western; Two-hybrid
TRPC4ITPR110991311163362 14505576 Affinity Capture-Western; Two-hybrid
BANK1ITPR110991311782428 Affinity Capture-Western
BANK1ITPR112035411782428 Affinity Capture-Western
CABP1ITPR111486312032348 14685260 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
CABP1ITPR110991312032348 14685260 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
AHCYL1ITPR110991312525476 Affinity Capture-Western; Reconstituted Complex
AHCYL1ITPR111598712525476 Affinity Capture-Western; Reconstituted Complex
SDC2ITPR111228512676536 Affinity Capture-Western
SDC2ITPR110991312676536 Affinity Capture-Western
TRPC1ITPR111307114505576 Affinity Capture-Western
TRPC1ITPR110991314505576 Affinity Capture-Western
TRPC2ITPR111307214505576 Affinity Capture-Western
TRPC2ITPR110991314505576 Affinity Capture-Western
TRPC3ITPR111307314505576 Affinity Capture-Western
TRPC3ITPR110991314505576 Affinity Capture-Western
TRPC5ITPR111307514505576 Affinity Capture-Western
TRPC5ITPR110991314505576 Affinity Capture-Western
TRPC6ITPR111307614505576 Affinity Capture-Western
TRPC6ITPR110991314505576 Affinity Capture-Western
STARD13ITPR112474414697242 Two-hybrid
STARD13ITPR110991314697242 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96623
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070604-2'