AutismKB 2.0

Annotation Details for ITPR2


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Basic Information Top
Gene Symbol:ITPR2 ( IP3R2 )
Gene Full Name: inositol 1,4,5-triphosphate receptor, type 2
Band: 12p11.23
Quick LinksEntrez ID:3709; OMIM: 600144; Uniprot ID:ITPR2_HUMAN; ENSEMBL ID: ENSG00000123104; HGNC ID: 6181
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus-
GO:0005783IDA-endoplasmic reticulum-
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005886IDA-plasma membrane10828023
GO:0005938IEA-cell cortex-
GO:0016020IDA-membrane19946888
GO:0016021IEA-integral component of membrane-
GO:0031095TAS-platelet dense tubular network membrane-
GO:0033017IMP-sarcoplasmic reticulum membrane10828023
GO:0043235IDA-receptor complex23382219
GO ID Evidence Qualifier GO_term References
GO:0005220ISS-inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity-
GO:0005509IBA-calcium ion binding-
GO:0015085TAS-calcium ion transmembrane transporter activity8081734
GO:0035091IEA-phosphatidylinositol binding-
GO ID Evidence Qualifier GO_term References
GO:0001666IDA-response to hypoxia19120137
GO:0006810TAS-transport8081734
GO:0007165TAS-signal transduction8081734
GO:0030168TAS-platelet activation-
GO:0048016IEA-inositol phosphate-mediated signaling-
GO:0050796TAS-regulation of insulin secretion-
GO:0051209IBA-release of sequestered calcium ion into cytosol-
GO:0051209ISS-release of sequestered calcium ion into cytosol-
GO:0071320IEA-cellular response to cAMP-
GO:0071361IEA-cellular response to ethanol-
GO:1903779TAS-regulation of cardiac conduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TRPC4ITPR211307411163362 Two-hybrid
TRPC4ITPR210991411163362 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99418
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050419-192'