AutismKB 2.0

Annotation Details for JAK1


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Basic Information Top
Gene Symbol:JAK1 ( JAK1A,JAK1B,JTK3 )
Gene Full Name: Janus kinase 1
Band: 1p31.3
Quick LinksEntrez ID:3716; OMIM: 147795; Uniprot ID:JAK1_HUMAN; ENSEMBL ID: ENSG00000162434; HGNC ID: 6190
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus10502458
GO:0005737IDA-cytoplasm10502458
GO:0005829TAS-cytosol-
GO:0005856IEA-cytoskeleton-
GO:0005925IDA-focal adhesion21423176
GO:0012505IEA-endomembrane system-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0004713EXP-protein tyrosine kinase activity1386289
GO:0004713TAS-protein tyrosine kinase activity-
GO:0004715IBA-non-membrane spanning protein tyrosine kinase activity-
GO:0004715TAS-non-membrane spanning protein tyrosine kinase activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005102IBA-receptor binding-
GO:0005131ISS-growth hormone receptor binding10502458
GO:0005515IPI-protein binding7759950
GO:0005524IEA-ATP binding-
GO:0019903IPI-protein phosphatase binding11909529
GO:0031625IPI-ubiquitin protein ligase binding24882218
GO:0031730IEA-CCR5 chemokine receptor binding-
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0006468TAS-protein phosphorylation1848670
GO:0007169IBA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0016477IBA-cell migration-
GO:0030154IBA-cell differentiation-
GO:0035556TAS-intracellular signal transduction8232552
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0038110IDA-interleukin-2-mediated signaling pathway11909529
GO:0042127IBA-regulation of cell proliferation-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045087IBA-innate immune response-
GO:0046677IDA-response to antibiotic16280321
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:0060334TAS-regulation of interferon-gamma-mediated signaling pathway-
GO:0060337TAS-type I interferon signaling pathway-
GO:0060338TAS-regulation of type I interferon-mediated signaling pathway-
GO:1903672IGI-positive regulation of sprouting angiogenesis20299512
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
JAK1ABL11065439774693 Reconstituted Complex
JAK1ABL11099199774693 Reconstituted Complex
JAK1ABL21065459774693 Affinity Capture-Western
JAK1ABL21099199774693 Affinity Capture-Western
JAK1ARRB110991917353931 Affinity Capture-MS
JAK1ARRB110690117353931 Affinity Capture-MS
JAK1ATIC10696117353931 Affinity Capture-MS
JAK1ATIC10991917353931 Affinity Capture-MS
JAK1BRCA110714011163768 Affinity Capture-Western
JAK1BRCA110991911163768 Affinity Capture-Western
JAK1BTK1071609178903 Affinity Capture-Western
JAK1BTK1099199178903 Affinity Capture-Western
JAK1CSF3R1078287512720 Affinity Capture-Western
JAK1CSF3R1099197512720 Affinity Capture-Western
JAK1ELF310991917353931 Affinity Capture-MS
JAK1ELF310831417353931 Affinity Capture-MS
JAK1PTK2B10848010702271 Affinity Capture-Western
JAK1PTK2B10991910702271 Affinity Capture-Western
JAK1GHR10991910502458 Affinity Capture-Western
JAK1GHR10895710502458 Affinity Capture-Western
JAK1GRB21091428536716 11527382 Affinity Capture-Western; Reconstituted Complex
JAK1GRB21099198536716 11527382 Affinity Capture-Western; Reconstituted Complex
JAK1IFNAR210991912133952 Reconstituted Complex
JAK1IFNAR210967712133952 Reconstituted Complex
JAK1IFNGR110991912133952 Reconstituted Complex
JAK1IFNGR110968112133952 Reconstituted Complex
JAK1IGF1R1097019492017 Reconstituted Complex
JAK1IGF1R1099199492017 Reconstituted Complex
JAK1IL2RB1099197973658 7973659 9553136 9774657 12133952 Affinity Capture-Western; Reconstituted Complex
JAK1IL2RB1097757973658 7973659 9553136 9774657 12133952 Affinity Capture-Western; Reconstituted Complex
JAK1IL4R10991912133952 Reconstituted Complex
JAK1IL4R10978012133952 Reconstituted Complex
JAK1IL5RA1099199516124 Affinity Capture-Western
JAK1IL5RA1097829516124 Affinity Capture-Western
JAK1IL6ST1099199388212 11468294 11742534 Affinity Capture-Western; Reconstituted Complex
JAK1IL6ST1097869388212 11468294 11742534 Affinity Capture-Western; Reconstituted Complex
JAK1IL9R1099198756628 Affinity Capture-Western
JAK1IL9R1097958756628 Affinity Capture-Western
JAK1IL10RA10980112133952 12374810 Reconstituted Complex
JAK1IL10RA10991912133952 12374810 Reconstituted Complex
JAK1IRS11099197499365 9492017 Affinity Capture-Western; Biochemical Activity
JAK1IRS11098747499365 9492017 Affinity Capture-Western; Biochemical Activity
IRS2JAK11142097499365 Affinity Capture-Western
IRS2JAK11099197499365 Affinity Capture-Western
TYK2JAK11099197589562 Affinity Capture-Western
TYK2JAK11131487589562 Affinity Capture-Western
PTPN6JAK11117427629131 Biochemical Activity
PTPN6JAK11099197629131 Biochemical Activity
PTPN11JAK11099198995399 12403768 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PTPN11JAK11117458995399 12403768 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
STAT5AJAK11126539047382 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STAT5AJAK11099199047382 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STAT5BJAK11126549047382 Affinity Capture-Western; Two-hybrid
STAT5BJAK11099199047382 Affinity Capture-Western; Two-hybrid
TECJAK11099199178903 Affinity Capture-Western
TECJAK11128659178903 Affinity Capture-Western
PLAURJAK11099199417082 Affinity Capture-Western
PLAURJAK11113459417082 Affinity Capture-Western
RAF1JAK11118319446616 Affinity Capture-Western
RAF1JAK11099199446616 Affinity Capture-Western
TNFRSF1AJAK11129869510175 11801527 Affinity Capture-Western; Reconstituted Complex
TNFRSF1AJAK11099199510175 11801527 Affinity Capture-Western; Reconstituted Complex
PRMT5JAK110991910531356 Reconstituted Complex
PRMT5JAK111568810531356 Reconstituted Complex
TSHRJAK110991910809230 Affinity Capture-Western
TSHRJAK111310410809230 Affinity Capture-Western
STAM2JAK110991910899310 10993906 Affinity Capture-Western; Biochemical Activity
STAM2JAK111554810899310 10993906 Affinity Capture-Western; Biochemical Activity
ELP2JAK112054110954736 Affinity Capture-Western; Reconstituted Complex
ELP2JAK110991910954736 Affinity Capture-Western; Reconstituted Complex
IL21RJAK111909511016959 Affinity Capture-Western
IL21RJAK110991911016959 Affinity Capture-Western
STAT3JAK110991911722592 11751884 Affinity Capture-Western; Reconstituted Complex
STAT3JAK111265111722592 11751884 Affinity Capture-Western; Reconstituted Complex
SHBJAK111235812200137 Reconstituted Complex
SHBJAK110991912200137 Reconstituted Complex
IL27RAJAK110991912734330 Affinity Capture-Western
IL27RAJAK111485212734330 Affinity Capture-Western
GNB2L1JAK110991912960323 Affinity Capture-Western; Reconstituted Complex
GNB2L1JAK111567112960323 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96628
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-142'