AutismKB 2.0

Annotation Details for JAK3


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Basic Information Top
Gene Symbol:JAK3 ( JAK-3,JAK3_HUMAN,JAKL,L-JAK,LJAK )
Gene Full Name: Janus kinase 3
Band: 19p13.11
Quick LinksEntrez ID:3718; OMIM: 600173; Uniprot ID:JAK3_HUMAN; ENSEMBL ID: ENSG00000105639; HGNC ID: 6193
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO:0005856IEA-cytoskeleton-
GO:0012505IEA-endomembrane system-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0004713ISS-protein tyrosine kinase activity-
GO:0004713TAS-protein tyrosine kinase activity-
GO:0004715IBA-non-membrane spanning protein tyrosine kinase activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005102IBA-receptor binding-
GO:0005515IPI-protein binding9045636
GO:0005524IEA-ATP binding-
GO:0019903IPI-protein phosphatase binding11909529
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0002250IEA-adaptive immune response-
GO:0002731ISS-negative regulation of dendritic cell cytokine production-
GO:0006468TAS-protein phosphorylation8022790
GO:0006954IBA-inflammatory response-
GO:0007167ISS-enzyme linked receptor protein signaling pathway-
GO:0007260TAS-tyrosine phosphorylation of STAT protein19290934
GO:0007262TAS-STAT protein import into nucleus19290934
GO:0016477IBA-cell migration-
GO:0018108ISS-peptidyl-tyrosine phosphorylation-
GO:0030183IBA-B cell differentiation-
GO:0030183ISS-B cell differentiation-
GO:0030218IBA-erythrocyte differentiation-
GO:0032693ISS-negative regulation of interleukin-10 production-
GO:0032695ISS-negative regulation of interleukin-12 production-
GO:0035556ISS-intracellular signal transduction-
GO:0035771IDA-interleukin-4-mediated signaling pathway7538655
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0042102IBA-positive regulation of T cell proliferation-
GO:0042981IBA-regulation of apoptotic process-
GO:0043029ISS-T cell homeostasis-
GO:0043029TAS-T cell homeostasis19290934
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045087IBA-innate immune response-
GO:0045221ISS-negative regulation of FasL biosynthetic process-
GO:0045626ISS-negative regulation of T-helper 1 cell differentiation-
GO:0050868ISS-negative regulation of T cell activation-
GO:0060397TAS-JAK-STAT cascade involved in growth hormone signaling pathway19290934
GO:0070232ISS-regulation of T cell apoptotic process-
GO:0070244ISS-negative regulation of thymocyte apoptotic process-
GO:0070669TAS-response to interleukin-29973401
GO:0070670IDA-response to interleukin-47538655
GO:0070672TAS-response to interleukin-157594533
GO:0071104TAS-response to interleukin-97594533
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
JAK3ALK10673911850821 14968112 Affinity Capture-MS; Affinity Capture-Western
JAK3ALK10992111850821 14968112 Affinity Capture-MS; Affinity Capture-Western
JAK3CD3E10992111349123 Affinity Capture-Western
JAK3CD3E10735411349123 Affinity Capture-Western
JAK3CD24710735711349123 Affinity Capture-Western; Reconstituted Complex
JAK3CD24710992111349123 Affinity Capture-Western; Reconstituted Complex
JAK3PTK2B1084809512511 Affinity Capture-Western
JAK3PTK2B1099219512511 Affinity Capture-Western
JAK3IL2RG1099217973658 7973659 Affinity Capture-Western
JAK3IL2RG1097767973658 7973659 Affinity Capture-Western
JAK3IRS11099217499365 Affinity Capture-Western
JAK3IRS11098747499365 Affinity Capture-Western
STAT5AJAK31099219047382 18250158 Affinity Capture-Western; Two-hybrid
STAT5AJAK31126539047382 18250158 Affinity Capture-Western; Two-hybrid
STAT5BJAK31099219047382 Two-hybrid
STAT5BJAK31126549047382 Two-hybrid
STAMJAK31099219133424 Affinity Capture-Western
STAMJAK31137229133424 Affinity Capture-Western
CXCR4JAK311360710506573 Affinity Capture-Western
CXCR4JAK310992110506573 Affinity Capture-Western
PRMT5JAK310992110531356 Reconstituted Complex
PRMT5JAK311568810531356 Reconstituted Complex
TIAF1JAK310992110733938 Affinity Capture-Western; Two-hybrid
TIAF1JAK311465310733938 Affinity Capture-Western; Two-hybrid
STAM2JAK310992110899310 Affinity Capture-Western
STAM2JAK311554810899310 Affinity Capture-Western
LEPRJAK310992111585385 Affinity Capture-Western
LEPRJAK311014411585385 Affinity Capture-Western
SHBJAK311235812200137 Reconstituted Complex
SHBJAK310992112200137 Reconstituted Complex
IKBKGJAK310992120098747 Reconstituted Complex
IKBKGJAK311408920098747 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
JAK3JAK32621187559633 JAK3B interacts with JAK3S.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99928
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070725-4'