AutismKB 2.0

Annotation Details for JUN


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Basic Information Top
Gene Symbol:JUN ( AP-1,AP1,c-Jun )
Gene Full Name: jun proto-oncogene
Band: 1p32.1
Quick LinksEntrez ID:3725; OMIM: 165160; Uniprot ID:JUN_HUMAN; ENSEMBL ID: ENSG00000177606; HGNC ID: 6204
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000228TAS-nuclear chromosome10918580
GO:0005634IDA-nucleus21113145
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005667IBA-transcription factor complex-
GO:0005719IDA-nuclear euchromatin19861239
GO:0005829IEA-cytosol-
GO:0017053IEA-transcriptional repressor complex-
GO:0035976IDA-transcription factor AP-1 complex10508860
GO:0035976IMP-transcription factor AP-1 complex26514923
GO ID Evidence Qualifier GO_term References
GO:0000978IBA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0000980IDA-RNA polymerase II distal enhancer sequence-specific DNA binding19861239
GO:0000981IC-RNA polymerase II transcription factor activity, sequence-specific DNA binding21113145
GO:0000982IMP-transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding19962668
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001102IPI-RNA polymerase II activating transcription factor binding10508860
GO:0001190IC-transcriptional activator activity, RNA polymerase II transcription factor binding19861239
GO:0003677TAS-DNA binding2825349
GO:0003682IEA-chromatin binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding9732876
GO:0003705IC-transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding19861239
GO:0003705IDA-transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding2833704
GO:0003713IDA-transcription coactivator activity2833704
GO:0003723IDA-RNA binding22681889
GO:0005096IDA-GTPase activator activity11804590
GO:0005515IPI-protein binding8440710
GO:0008134IPI-transcription factor binding16007074
GO:0019899IPI-enzyme binding23382074
GO:0035497IDA-cAMP response element binding19861239
GO:0042802IPI-identical protein binding20102225
GO:0042803IDA-protein homodimerization activity10508860
GO:0044212IDA-transcription regulatory region DNA binding9732876
GO:0046982IDA-protein heterodimerization activity10508860
GO:0070412IPI-R-SMAD binding9732876
GO:0071837IEA-HMG box domain binding-
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0001774IEA-microglial cell activation-
GO:0001836IEA-release of cytochrome c from mitochondria-
GO:0001889IEA-liver development-
GO:0001938IEA-positive regulation of endothelial cell proliferation-
GO:0003151IEA-outflow tract morphogenesis-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0007179IDA-transforming growth factor beta receptor signaling pathway9732876
GO:0007184IDA-SMAD protein import into nucleus9732876
GO:0007265IDA-Ras protein signal transduction24623306
GO:0007568IEA-aging-
GO:0007612IEA-learning-
GO:0007623IEA-circadian rhythm-
GO:0008285IEA-negative regulation of cell proliferation-
GO:0009314IBA-response to radiation-
GO:0009612IBA-response to mechanical stimulus-
GO:0010634IEA-positive regulation of epithelial cell migration-
GO:0010941IBA-regulation of cell death-
GO:0030224IEA-monocyte differentiation-
GO:0031103IEA-axon regeneration-
GO:0031953IEA-negative regulation of protein autophosphorylation-
GO:0032496IBA-response to lipopolysaccharide-
GO:0032870IBA-cellular response to hormone stimulus-
GO:0034097IBA-response to cytokine-
GO:0034614IMP-cellular response to reactive oxygen species26514923
GO:0035026IEA-leading edge cell differentiation-
GO:0035994IEA-response to muscle stretch-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0042127IBA-regulation of cell proliferation-
GO:0042493IBA-response to drug-
GO:0042542IEA-response to hydrogen peroxide-
GO:0043065IMP-positive regulation of apoptotic process10508860
GO:0043392IDA-negative regulation of DNA binding14645924
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0043525IEA-positive regulation of neuron apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043922IDA-negative regulation by host of viral transcription2833704
GO:0043923IDA-positive regulation by host of viral transcription2833704
GO:0045597IBA-positive regulation of cell differentiation-
GO:0045657IEA-positive regulation of monocyte differentiation-
GO:0045740IEA-positive regulation of DNA replication-
GO:0045892IDA-negative regulation of transcription, DNA-templated2833704
GO:0045893IDA-positive regulation of transcription, DNA-templated2833704
GO:0045893IMP-positive regulation of transcription, DNA-templated26514923
GO:0045944IC-positive regulation of transcription from RNA polymerase II promoter19861239
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter2833704
GO:0048146IEA-positive regulation of fibroblast proliferation-
GO:0048661IEA-positive regulation of smooth muscle cell proliferation-
GO:0051090TAS-regulation of sequence-specific DNA binding transcription factor activity-
GO:0051365IEA-cellular response to potassium ion starvation-
GO:0051591IBA-response to cAMP-
GO:0051726IBA-regulation of cell cycle-
GO:0051899IEA-membrane depolarization-
GO:0060395IDA-SMAD protein signal transduction9732876
GO:0061029IEA-eyelid development in camera-type eye-
GO:0070374IEA-positive regulation of ERK1 and ERK2 cascade-
GO:0071276IMP-cellular response to cadmium ion26514923
GO:0071277IEA-cellular response to calcium ion-
GO:1902895IMP-positive regulation of pri-miRNA transcription from RNA polymerase II promoter19962668
GO:1902895ISS-positive regulation of pri-miRNA transcription from RNA polymerase II promoter-
GO:1990441IMP-negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress21113145
GO:2000144IDA-positive regulation of DNA-templated transcription, initiation23027619
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
JUNAPLP210992820936779 Two-hybrid
JUNAPLP210683120936779 Two-hybrid
JUNAR1099289211894 Affinity Capture-Western
JUNAR1068629211894 Affinity Capture-Western
JUNPHOX2A10689414506227 Reconstituted Complex
JUNPHOX2A10992814506227 Reconstituted Complex
JUNARRB110992820936779 Two-hybrid
JUNARRB110690120936779 Two-hybrid
JUNATF31069571827203 8622660 14667575 Affinity Capture-Western; Reconstituted Complex
JUNATF31099281827203 8622660 14667575 Affinity Capture-Western; Reconstituted Complex
JUNATF41069581827203 20936779 Reconstituted Complex; Two-hybrid
JUNATF41099281827203 20936779 Reconstituted Complex; Two-hybrid
JUNBCL310992810497212 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUNBCL310707410497212 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUNBCL610707612165517 Reconstituted Complex; Two-hybrid
JUNBCL610992812165517 Reconstituted Complex; Two-hybrid
JUNBRCA110992812080089 Affinity Capture-Western; Reconstituted Complex
JUNBRCA110714012080089 Affinity Capture-Western; Reconstituted Complex
JUNRUNX210992811274169 11641401 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUNRUNX210730811274169 11641401 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUNRUNX110992811274169 11641401 Affinity Capture-Western; Reconstituted Complex
JUNRUNX110730911274169 11641401 Affinity Capture-Western; Reconstituted Complex
JUNCDKN1A10992820102411 Affinity Capture-Western
JUNCDKN1A10746020102411 Affinity Capture-Western
JUNCEBPA10992817082780 Affinity Capture-Western
JUNCEBPA10747917082780 Affinity Capture-Western
JUNATF21099281827203 2320002 8027667 Affinity Capture-Western; Reconstituted Complex
JUNATF21077761827203 2320002 8027667 Affinity Capture-Western; Reconstituted Complex
JUNCREBBP1099289659924 9786917 Affinity Capture-Western; Reconstituted Complex
JUNCREBBP1077779659924 9786917 Affinity Capture-Western; Reconstituted Complex
JUNCSK10783216740711 Affinity Capture-Western; Biochemical Activity; Two-hybrid
JUNCSK10992816740711 Affinity Capture-Western; Biochemical Activity; Two-hybrid
JUNCSNK2A11099289685505 Far Western; Reconstituted Complex
JUNCSNK2A11078419685505 Far Western; Reconstituted Complex
JUNCSNK2A21099289685505 Far Western; Reconstituted Complex
JUNCSNK2A21078429685505 Far Western; Reconstituted Complex
JUNDACH110992816980615 17182846 Affinity Capture-Western; Two-hybrid
JUNDACH110797216980615 17182846 Affinity Capture-Western; Two-hybrid
JUNDDIT310992810523647 Affinity Capture-Western; Reconstituted Complex
JUNDDIT310801610523647 Affinity Capture-Western; Reconstituted Complex
JUNDHX910992811823437 Affinity Capture-MS
JUNDHX910802511823437 Affinity Capture-MS
JUNTSC22D310992811397794 Reconstituted Complex
JUNTSC22D310816511397794 Reconstituted Complex
JUNEP30010992811980644 12437352 Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Reconstituted Complex
JUNEP30010834711980644 12437352 Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Reconstituted Complex
JUNERG10992811278640 Reconstituted Complex
JUNERG10838911278640 Reconstituted Complex
JUNESR110992811477071 17317669 Affinity Capture-Western; Reconstituted Complex
JUNESR110840311477071 17317669 Affinity Capture-Western; Reconstituted Complex
JUNETS11084148557686 Reconstituted Complex
JUNETS11099288557686 Reconstituted Complex
JUNETS21099289334186 Reconstituted Complex; Two-hybrid
JUNETS21084159334186 Reconstituted Complex; Two-hybrid
JUNFOS1086367816143 8380166 8440710 9160889 9872330 10488148 11053448 11431474 16714286 20936779 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
JUNFOS1099287816143 8380166 8440710 9160889 9872330 10488148 11053448 11431474 16714286 20936779 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
JUNFOSL21099289160889 Two-hybrid
JUNFOSL21086389160889 Two-hybrid
JUNNR5A110992810478848 Reconstituted Complex
JUNNR5A110879210478848 Reconstituted Complex
JUNGATA210992811278891 Reconstituted Complex
JUNGATA210889411278891 Reconstituted Complex
JUNNR3C110992814522952 Reconstituted Complex
JUNNR3C110916514522952 Reconstituted Complex
JUNGTF2B1099287848298 Reconstituted Complex
JUNGTF2B1092147848298 Reconstituted Complex
JUNGTF2E21092168628277 Reconstituted Complex
JUNGTF2E21099288628277 Reconstituted Complex
JUNGTF2F11092178628277 Reconstituted Complex
JUNGTF2F11099288628277 Reconstituted Complex
JUNGTF2F21092188628277 Reconstituted Complex
JUNGTF2F21099288628277 Reconstituted Complex
JUNHDAC110931517056544 Affinity Capture-Western
JUNHDAC110992817056544 Affinity Capture-Western
JUNHIF1A10933811739718 Affinity Capture-Western
JUNHIF1A10992811739718 Affinity Capture-Western
JUNHMGA110992810357819 10428834 Reconstituted Complex; Two-hybrid
JUNHMGA110940210357819 10428834 Reconstituted Complex; Two-hybrid
JUNHSP90AA110992820936779 Two-hybrid
JUNHSP90AA110955220936779 Two-hybrid
MYOD1JUN1099281310896 Affinity Capture-Western; Reconstituted Complex
MYOD1JUN1107371310896 Affinity Capture-Western; Reconstituted Complex
MAPK3JUN1099281922387 Biochemical Activity
MAPK3JUN1115811922387 Biochemical Activity
RPS6KA2JUN1099287623830 Biochemical Activity
RPS6KA2JUN1121107623830 Biochemical Activity
TBPJUN1099287848298 Reconstituted Complex
TBPJUN1127717848298 Reconstituted Complex
JUNJUN1099287848298 8440710 10488148 Reconstituted Complex; Two-hybrid
MAPK8JUN1099288137421 8586671 8621542 9207092 9774977 11479302 12052834 14633987 16740711 16983342 Biochemical Activity; Reconstituted Complex; Two-hybrid
MAPK8JUN1115858137421 8586671 8621542 9207092 9774977 11479302 12052834 14633987 16740711 16983342 Biochemical Activity; Reconstituted Complex; Two-hybrid
TOP2AJUN1099288387155 Far Western
TOP2AJUN1130068387155 Far Western
CREB5JUN1099288440710 Reconstituted Complex
CREB5JUN1149548440710 Reconstituted Complex
POU1F1JUN1099288663380 Reconstituted Complex
POU1F1JUN1114458663380 Reconstituted Complex
TCF20JUN1099288663478 Reconstituted Complex
TCF20JUN1128028663478 Reconstituted Complex
UBE2IJUN1099288733011 Two-hybrid
UBE2IJUN1131778733011 Two-hybrid
COPS5JUN1099288837781 Affinity Capture-Western; Co-localization; Two-hybrid
COPS5JUN1161838837781 Affinity Capture-Western; Co-localization; Two-hybrid
MAPK9JUN1099288945519 Biochemical Activity
MAPK9JUN1115878945519 Biochemical Activity
FOSL1JUN1099289160889 11431474 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FOSL1JUN1137429160889 11431474 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NACAJUN1099289488446 Reconstituted Complex; Two-hybrid
NACAJUN1107489488446 Reconstituted Complex; Two-hybrid
NCOA1JUN1099289642216 10567404 10847592 Reconstituted Complex; Two-hybrid
NCOA1JUN1142009642216 10567404 10847592 Reconstituted Complex; Two-hybrid
PMLJUN1099289671405 Reconstituted Complex
PMLJUN1113849671405 Reconstituted Complex
SPI1JUN1099289681824 Reconstituted Complex
SPI1JUN1125669681824 Reconstituted Complex
SMAD3JUN1099289732876 10220381 10903323 11306568 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SMAD3JUN1102639732876 10220381 10903323 11306568 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PPP4CJUN1099289837938 Reconstituted Complex
PPP4CJUN1115239837938 Reconstituted Complex
NFE2L1JUN1099289872330 Affinity Capture-Western; Reconstituted Complex
NFE2L1JUN1108519872330 Affinity Capture-Western; Reconstituted Complex
NFE2L2JUN1099289872330 Affinity Capture-Western; Reconstituted Complex
NFE2L2JUN1108529872330 Affinity Capture-Western; Reconstituted Complex
RB1JUN10992810026157 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RB1JUN11186010026157 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SPIBJUN10992810196196 Reconstituted Complex
SPIBJUN11256710196196 Reconstituted Complex
VDRJUN10992810330159 Reconstituted Complex
VDRJUN11326410330159 Reconstituted Complex
RELAJUN10992810488148 Phenotypic Enhancement; Two-hybrid
RELAJUN11190210488148 Phenotypic Enhancement; Two-hybrid
STAT1JUN10992810490649 Affinity Capture-Western
STAT1JUN11264910490649 Affinity Capture-Western
STAT3JUN10992810490649 Affinity Capture-Western; Reconstituted Complex
STAT3JUN11265110490649 Affinity Capture-Western; Reconstituted Complex
SP1JUN10992810506225 16478997 Affinity Capture-Western; Reconstituted Complex
SP1JUN11255010506225 16478997 Affinity Capture-Western; Reconstituted Complex
NCOR2JUN10992810777532 Reconstituted Complex; Two-hybrid
NCOR2JUN11497410777532 Reconstituted Complex; Two-hybrid
NCOA6JUN10992810847592 Reconstituted Complex
NCOA6JUN11669110847592 Reconstituted Complex
VAV1JUN10992811287617 Biochemical Activity
VAV1JUN11325211287617 Biochemical Activity
TAF1JUN10992811316804 Reconstituted Complex
TAF1JUN11273511316804 Reconstituted Complex
SARSJUN10992811331419 Affinity Capture-Western
SARSJUN11220811331419 Affinity Capture-Western
SMAD2JUN10992811371641 Affinity Capture-Western
SMAD2JUN11026211371641 Affinity Capture-Western
TGIF1JUN10992811371641 Affinity Capture-Western; Reconstituted Complex
TGIF1JUN11290811371641 Affinity Capture-Western; Reconstituted Complex
MAPK1JUN10992811431474 Affinity Capture-Western
MAPK1JUN11158011431474 Affinity Capture-Western
PIN1JUN10992811432833 Affinity Capture-Western; Reconstituted Complex
PIN1JUN11131711432833 Affinity Capture-Western; Reconstituted Complex
RBM39JUN10992811704680 Reconstituted Complex; Two-hybrid
RBM39JUN11495211704680 Reconstituted Complex; Two-hybrid
STAT4JUN10992811801649 Affinity Capture-Western
STAT4JUN11265211801649 Affinity Capture-Western
HNRNPMJUN10992811823437 Affinity Capture-MS
HNRNPMJUN11075111823437 Affinity Capture-MS
DDX21JUN10992811823437 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
DDX21JUN11462511823437 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SUMO1JUN10992811867732 15469925 PCA; Reconstituted Complex
SUMO1JUN11318811867732 15469925 PCA; Reconstituted Complex
PIAS1JUN10992811867732 Reconstituted Complex
PIAS1JUN11412411867732 Reconstituted Complex
PIAS2JUN10992811867732 Reconstituted Complex
PIAS2JUN11452311867732 Reconstituted Complex
NFYAJUN11086611903046 Affinity Capture-Western
NFYAJUN10992811903046 Affinity Capture-Western
PRKD1JUN10992811948398 Biochemical Activity
PRKD1JUN11157311948398 Biochemical Activity
SKIJUN10992812034730 Affinity Capture-Western
SKIJUN11238812034730 Affinity Capture-Western
ASCC3JUN10992812077347 Reconstituted Complex; Two-hybrid
ASCC3JUN11617012077347 Reconstituted Complex; Two-hybrid
ASCC1JUN10992812077347 Reconstituted Complex; Two-hybrid
ASCC1JUN11921512077347 Reconstituted Complex; Two-hybrid
ASCC2JUN12392112077347 Reconstituted Complex; Two-hybrid
ASCC2JUN10992812077347 Reconstituted Complex; Two-hybrid
NRIP1JUN10992812554755 Reconstituted Complex
NRIP1JUN11384312554755 Reconstituted Complex
RFWD2JUN10992812615916 14739464 Affinity Capture-Western
RFWD2JUN12213612615916 14739464 Affinity Capture-Western
HDAC3JUN10992812853483 Affinity Capture-Western
HDAC3JUN11436812853483 Affinity Capture-Western
UBCJUN10992815469925 16569633 16740711 16901904 17592138 17952113 18716056 20936779 Affinity Capture-Western; PCA; Two-hybrid
UBCJUN11316415469925 16569633 16740711 16901904 17592138 17952113 18716056 20936779 Affinity Capture-Western; PCA; Two-hybrid
COBRA1JUN11742115530430 Affinity Capture-Western; Reconstituted Complex
COBRA1JUN10992815530430 Affinity Capture-Western; Reconstituted Complex
HDAC9JUN10992816611996 Reconstituted Complex
HDAC9JUN11508316611996 Reconstituted Complex
SUMO3JUN10992816620772 Affinity Capture-MS
SUMO3JUN11249616620772 Affinity Capture-MS
SUMO2JUN10992816620772 Affinity Capture-MS
SUMO2JUN11249716620772 Affinity Capture-MS
MYST2JUN10992816880509 Affinity Capture-Western; Reconstituted Complex
MYST2JUN11631516880509 Affinity Capture-Western; Reconstituted Complex
EDF1JUN10992816880509 Affinity Capture-Western; Reconstituted Complex
EDF1JUN11426016880509 Affinity Capture-Western; Reconstituted Complex
ITCHJUN10992816901904 Reconstituted Complex
ITCHJUN12374716901904 Reconstituted Complex
PPP3CBJUN10992817952113 FRET; Reconstituted Complex
PPP3CBJUN11152417952113 FRET; Reconstituted Complex
JDP2JUN12580718671972 Affinity Capture-Western
JDP2JUN10992818671972 Affinity Capture-Western
SIRT1JUN10992818823944 Affinity Capture-Western
SIRT1JUN11698318823944 Affinity Capture-Western
MAZJUN11032019028685 Affinity Capture-Western; Far Western
MAZJUN10992819028685 Affinity Capture-Western; Far Western
MACF1JUN10992820936779 Two-hybrid
MACF1JUN11704820936779 Two-hybrid
MLL3JUN12183520936779 Two-hybrid
MLL3JUN10992820936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
JUNMAPK141958799155018 An unspecified isoform of p38 interacts with and phosphorylates c-Jun.
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
JUNrs11688 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:96646
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-7859'