AutismKB 2.0

Annotation Details for JUP


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Basic Information Top
Gene Symbol:JUP ( ARVD12,CTNNG,DP3,DPIII,PDGB,PKGB )
Gene Full Name: junction plakoglobin
Band: 17q21.2
Quick LinksEntrez ID:3728; OMIM: 173325; Uniprot ID:PLAK_HUMAN; ENSEMBL ID: ENSG00000173801; HGNC ID: 6207
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001533TAS-cornified envelope-
GO:0005576TAS-extracellular region-
GO:0005634IMP-nucleus14661054
GO:0005737IMP-cytoplasm14661054
GO:0005829ISS-cytosol-
GO:0005856ISS-cytoskeleton-
GO:0005882IEA-intermediate filament-
GO:0005886IDA-plasma membrane14661054
GO:0005886TAS-plasma membrane-
GO:0005911IDA-cell-cell junction1639850
GO:0005913IDA-cell-cell adherens junction10403777
GO:0005915ISS-zonula adherens-
GO:0005916IEA-fascia adherens-
GO:0005925IDA-focal adhesion21423176
GO:0009898ISS-cytoplasmic side of plasma membrane-
GO:0014704IDA-intercalated disc22781308
GO:0015629IEA-actin cytoskeleton-
GO:0016327IEA-apicolateral plasma membrane-
GO:0016328IEA-lateral plasma membrane-
GO:0016342IDA-catenin complex7650039
GO:0030018IEA-Z disc-
GO:0030056ISSNOThemidesmosome-
GO:0030057IDA-desmosome1639850
GO:0031012IDA-extracellular matrix23979707
GO:0032993IDA-protein-DNA complex14661054
GO:0035580TAS-specific granule lumen-
GO:0070062IDA-extracellular exosome19056867
GO:0071665IDA-gamma-catenin-TCF7L2 complex14661054
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0003713IDA-transcription coactivator activity14661054
GO:0004871IEA-signal transducer activity-
GO:0005198NAS-structural molecule activity22889254
GO:0005199IC-structural constituent of cell wall7650039
GO:0005515IPI-protein binding7890674
GO:0019901IEA-protein kinase binding-
GO:0019903IPI-protein phosphatase binding8663237
GO:0042803ISS-protein homodimerization activity-
GO:0045294IPI-alpha-catenin binding7650039
GO:0045296IDA-cadherin binding25468996
GO:0045296IPI-cadherin binding1639850
GO:0050839IPI-cell adhesion molecule binding17559062
GO:0086083IC-cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication17924338
GO ID Evidence Qualifier GO_term References
GO:0002159IDA-desmosome assembly22889254
GO:0002159IMP-desmosome assembly20859650
GO:0007016NAS-cytoskeletal anchoring at plasma membrane22889254
GO:0007165IEA-signal transduction-
GO:0016337IDA-single organismal cell-cell adhesion18937352
GO:0016337IMP-single organismal cell-cell adhesion20859650
GO:0016477IMP-cell migration18937352
GO:0031424TAS-keratinization-
GO:0034332TAS-adherens junction organization-
GO:0034333IEA-adherens junction assembly-
GO:0042127IDA-regulation of cell proliferation17924338
GO:0042307IDA-positive regulation of protein import into nucleus10825188
GO:0043312TAS-neutrophil degranulation-
GO:0050982IDA-detection of mechanical stimulus18937352
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity14661054
GO:0051291IEA-protein heterooligomerization-
GO:0070268TAS-cornification-
GO:0071603ISS-endothelial cell-cell adhesion-
GO:0071681IDA-cellular response to indole-3-methanol10868478
GO:0086073IMP-bundle of His cell-Purkinje myocyte adhesion involved in cell communication17924338
GO:0086091IMP-regulation of heart rate by cardiac conduction17924338
GO:0090002IMP-establishment of protein localization to plasma membrane20859650
GO:0090263IC-positive regulation of canonical Wnt signaling pathway14661054
GO:0098911IMP-regulation of ventricular cardiac muscle cell action potential17924338
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
JUPAPC1068217651399 8074697 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUPAPC1099317651399 8074697 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUPBIRC210682616189514 Two-hybrid
JUPBIRC210993116189514 Two-hybrid
JUPARHGDIA10993116169070 Two-hybrid
JUPARHGDIA10688916169070 Two-hybrid
JUPCDH11099311639850 7542250 8074697 8207061 9535896 Affinity Capture-Western; Reconstituted Complex
JUPCDH11074341639850 7542250 8074697 8207061 9535896 Affinity Capture-Western; Reconstituted Complex
JUPCDH21099317650039 14625392 Affinity Capture-MS; Affinity Capture-Western
JUPCDH21074357650039 14625392 Affinity Capture-MS; Affinity Capture-Western
JUPCDH310993110910767 Affinity Capture-Western; Co-purification
JUPCDH310743610910767 Affinity Capture-Western; Co-purification
JUPCDH51099319434630 12003790 Affinity Capture-Western
JUPCDH51074389434630 12003790 Affinity Capture-Western
JUPCTNNA11099317650039 9110993 9762469 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUPCTNNA11078767650039 9110993 9762469 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUPCTNNB11078809535896 11712088 Affinity Capture-Western
JUPCTNNB11099319535896 11712088 Affinity Capture-Western
JUPDSC110993114673151 Two-hybrid
JUPDSC110815714673151 Two-hybrid
JUPDSC21099319443898 Affinity Capture-Western
JUPDSC21081589443898 Affinity Capture-Western
JUPDSC310993110769211 Affinity Capture-Western
JUPDSC310815910769211 Affinity Capture-Western
JUPDSG11099319606214 Reconstituted Complex
JUPDSG11081629606214 Reconstituted Complex
JUPDSG21099318749329 10769205 11710948 Affinity Capture-Western; Reconstituted Complex
JUPDSG21081638749329 10769205 11710948 Affinity Capture-Western; Reconstituted Complex
JUPDSG31099317738346 Affinity Capture-Western
JUPDSG31081647738346 Affinity Capture-Western
JUPDSP1099319348293 9739078 Affinity Capture-Western; Two-hybrid
JUPDSP1081669348293 9739078 Affinity Capture-Western; Two-hybrid
JUPEGFR1099319535896 Reconstituted Complex
JUPEGFR1082769535896 Reconstituted Complex
JUPERBB21099317702605 Far Western
JUPERBB21083767702605 Far Western
JUPGJB11099317971964 Affinity Capture-Western
JUPGJB11089717971964 Affinity Capture-Western
PTPRKJUP1099318663237 Affinity Capture-Western; Reconstituted Complex
PTPRKJUP1117608663237 Affinity Capture-Western; Reconstituted Complex
PTPRFJUP1099319245795 Reconstituted Complex
PTPRFJUP1117569245795 Reconstituted Complex
PECAM1JUP10993110801826 Affinity Capture-Western
PECAM1JUP11120110801826 Affinity Capture-Western
BTRCJUP11445710803460 Affinity Capture-Western
BTRCJUP10993110803460 Affinity Capture-Western
TCF7L2JUP11279511711551 Reconstituted Complex
TCF7L2JUP10993111711551 Reconstituted Complex
PKP2JUP10993111790773 Affinity Capture-Western; Two-hybrid
PKP2JUP11133511790773 Affinity Capture-Western; Two-hybrid
RAB8BJUP11971912639940 Affinity Capture-Western
RAB8BJUP10993112639940 Affinity Capture-Western
PKP3JUP11635712707304 Two-hybrid
PKP3JUP10993112707304 Two-hybrid
PTPN14JUP10993112808048 Affinity Capture-MS
PTPN14JUP11174812808048 Affinity Capture-MS
MUC1JUP10993112939402 Affinity Capture-Western; Co-localization
MUC1JUP11066912939402 Affinity Capture-Western; Co-localization
CTNNBIP1JUP10993116189514 17353931 Affinity Capture-MS; Two-hybrid
CTNNBIP1JUP12131316189514 17353931 Affinity Capture-MS; Two-hybrid
RIBC2JUP11758116189514 Two-hybrid
RIBC2JUP10993116189514 Two-hybrid
NFKBIEJUP10993116189514 Two-hybrid
NFKBIEJUP11086116189514 Two-hybrid
WDYHV1JUP12040516189514 Two-hybrid
WDYHV1JUP10993116189514 Two-hybrid
PHB2JUP10993117353931 Affinity Capture-MS
PHB2JUP11645917353931 Affinity Capture-MS
LGALS9JUP10993117353931 Affinity Capture-MS
LGALS9JUP11015617353931 Affinity Capture-MS
USP1JUP11324119615732 Affinity Capture-MS
USP1JUP10993119615732 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
JUPDSP18315712426320 Plakoglobin interacts with desmoplakin.
PKP3JUP25967812707304 PKP3 interacts with JUP(Pg)
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96650
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-991207-22'