Gene Symbol:	AREG ( AR,AREGB,CRDGF,MGC13647,SDGF )
Gene Full Name:	amphiregulin
Band:	4q13.3
Quick Links	Entrez ID:374; OMIM: 104640; Uniprot ID:AREG_HUMAN; ENSEMBL ID: ENSG00000109321; HGNC ID: 651
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000139	IEA	-	Golgi membrane	-
GO:0005615	IBA	-	extracellular space	-
GO:0005615	IDA	-	extracellular space	12743035
GO:0005634	IEA	-	nucleus	-
GO:0005789	TAS	-	endoplasmic reticulum membrane	-
GO:0009986	IDA	-	cell surface	12743035
GO:0012507	TAS	-	ER to Golgi transport vesicle membrane	-
GO:0016021	IEA	-	integral component of membrane	-
GO:0033116	TAS	-	endoplasmic reticulum-Golgi intermediate compartment membrane	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0005125	IEA	-	cytokine activity	-
GO:0005154	IBA	-	epidermal growth factor receptor binding	-
GO:0005515	IPI	-	protein binding	19740107
GO:0008083	IBA	-	growth factor activity	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0006888	TAS	-	ER to Golgi vesicle-mediated transport	-
GO:0007173	IBA	-	epidermal growth factor receptor signaling pathway	-
GO:0007173	IDA	-	epidermal growth factor receptor signaling pathway	12743035
GO:0007186	IDA	-	G-protein coupled receptor signaling pathway	12743035
GO:0007267	TAS	-	cell-cell signaling	2466334
GO:0008283	TAS	-	cell proliferation	2466334
GO:0008284	IBA	-	positive regulation of cell proliferation	-
GO:0014009	IEA	-	glial cell proliferation	-
GO:0031175	IEA	-	neuron projection development	-
GO:0032355	IEA	-	response to estradiol	-
GO:0042542	IEA	-	response to hydrogen peroxide	-
GO:0043434	IEA	-	response to peptide hormone	-
GO:0045668	IEA	-	negative regulation of osteoblast differentiation	-
GO:0045740	IMP	-	positive regulation of DNA replication	12743035
GO:0048208	TAS	-	COPII vesicle coating	-
GO:0050731	IEA	-	positive regulation of peptidyl-tyrosine phosphorylation	-
GO:0051384	IEA	-	response to glucocorticoid	-
GO:0051591	IEA	-	response to cAMP	-
GO:0060598	IEA	-	dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis	-
GO:0060744	IEA	-	mammary gland branching involved in thelarche	-
GO:0060749	IEA	-	mammary gland alveolus development	-
GO:0060750	IEA	-	epithelial cell proliferation involved in mammary gland duct elongation	-

Gene Symbol	Interactant	Interaction ID	References	Description
EGFR	AREG	106869	10085134	Reconstituted Complex
EGFR	AREG	108276	10085134	Reconstituted Complex

AutismKB 2.0

Annotation Details for AREG