AutismKB 2.0

Annotation Details for KCNB1


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Basic Information Top
Gene Symbol:KCNB1 ( DRK1,KV2.1,h-DRK1 )
Gene Full Name: potassium voltage-gated channel, Shab-related subfamily, member 1
Band: 20q13.13
Quick LinksEntrez ID:3745; OMIM: 600397; Uniprot ID:KCNB1_HUMAN; ENSEMBL ID: ENSG00000158445; HGNC ID: 6231
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IEA-intracellular-
GO:0005886IDA-plasma membrane19074135
GO:0005886TAS-plasma membrane-
GO:0008076IDA-voltage-gated potassium channel complex19074135
GO:0008076ISS-voltage-gated potassium channel complex-
GO:0016328IEA-lateral plasma membrane-
GO:0030054IEA-cell junction-
GO:0030424ISS-axon-
GO:0030425ISS-dendrite-
GO:0032809ISS-neuronal cell body membrane-
GO:0042383IEA-sarcolemma-
GO:0043204ISS-perikaryon-
GO:0045211IEA-postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0005251IDA-delayed rectifier potassium channel activity19074135
GO:0005251ISS-delayed rectifier potassium channel activity-
GO:0005515IPI-protein binding10484328
GO:0032182IPI-ubiquitin-like protein binding19223394
GO:0044325IPI-ion channel binding19074135
GO:0046982ISS-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0001508IDA-action potential19223394
GO:0006904ISS-vesicle docking involved in exocytosis-
GO:0007215ISS-glutamate receptor signaling pathway-
GO:0010701ISS-positive regulation of norepinephrine secretion-
GO:0031669ISS-cellular response to nutrient levels-
GO:0033605ISS-positive regulation of catecholamine secretion-
GO:0034765IEA-regulation of ion transmembrane transport-
GO:0042593ISS-glucose homeostasis-
GO:0045956ISS-positive regulation of calcium ion-dependent exocytosis-
GO:0046676ISS-negative regulation of insulin secretion-
GO:0050796TAS-regulation of insulin secretion-
GO:0051260IEA-protein homooligomerization-
GO:0071333ISS-cellular response to glucose stimulus-
GO:0071805IDA-potassium ion transmembrane transport19074135
GO:0071805ISS-potassium ion transmembrane transport-
GO:0072661ISS-protein targeting to plasma membrane-
GO:0090314IDA-positive regulation of protein targeting to membrane19074135
GO:0090314ISS-positive regulation of protein targeting to membrane-
GO:0098900ISS-regulation of action potential-
GO:1900454ISS-positive regulation of long term synaptic depression-
GO:2000671ISS-regulation of motor neuron apoptotic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KCNS3KCNB11099479362476 Affinity Capture-Western
KCNS3KCNB11099919362476 Affinity Capture-Western
KCNG2KCNB110994710551266 Two-hybrid
KCNG2KCNB111763810551266 Two-hybrid
PTPREKCNB110994710921884 Affinity Capture-Western; Reconstituted Complex
PTPREKCNB111175510921884 Affinity Capture-Western; Reconstituted Complex
KCNV2KCNB110994712060745 Affinity Capture-Western; Two-hybrid
KCNV2KCNB112798212060745 Affinity Capture-Western; Two-hybrid
KCNG3KCNB110994712060745 Affinity Capture-Western; Two-hybrid
KCNG3KCNB112809012060745 Affinity Capture-Western; Two-hybrid
KCNH1KCNB110994712060745 Affinity Capture-Western; Two-hybrid
KCNH1KCNB110995812060745 Affinity Capture-Western; Two-hybrid
KCNB1KCNB110994712060745 Two-hybrid
SNAP25KCNB110994712403834 Reconstituted Complex
SNAP25KCNB111250012403834 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96666
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090831-3'