Annotation Details for KCNN4

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Basic Information Top

Gene Symbol:	KCNN4 ( IK1,IKCA1,KCA4,KCa3.1,SK4,hIKCa1,hKCa4,hSK4 )
Gene Full Name:	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
Band:	19q13.31
Quick Links	Entrez ID:3783; OMIM: 602754; Uniprot ID:KCNN4_HUMAN; ENSEMBL ID: ENSG00000104783; HGNC ID: 6293
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:5 results
Molecular Function:6 results
Biological Process:11 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005886	IDA	-	plasma membrane	26148990
GO:0005886	TAS	-	plasma membrane	-
GO:0008076	IC	-	voltage-gated potassium channel complex	18796614
GO:0031982	IDA	-	vesicle	25468996
GO:0043025	IBA	-	neuronal cell body	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0005267	TAS	-	potassium channel activity	-
GO:0005515	IPI	-	protein binding	12198491
GO:0005516	IBA	-	calmodulin binding	-
GO:0015269	IDA	-	calcium-activated potassium channel activity	18796614
GO:0016286	IBA	-	small conductance calcium-activated potassium channel activity	-
GO:0019903	IPI	-	protein phosphatase binding	18796614

GO ID	Evidence	Qualifier	GO_term	References
GO:0002376	IEA	-	immune system process	-
GO:0006813	TAS	-	potassium ion transport	9380751
GO:0006816	IDA	-	calcium ion transport	18796614
GO:0006884	IEA	-	cell volume homeostasis	-
GO:0006952	TAS	-	defense response	9407042
GO:0030322	IDA	-	stabilization of membrane potential	18796614
GO:0045332	IEA	-	phospholipid translocation	-
GO:0046541	IEA	-	saliva secretion	-
GO:0050714	IEA	-	positive regulation of protein secretion	-
GO:0050862	IDA	-	positive regulation of T cell receptor signaling pathway	18796614
GO:0071805	IEA	-	potassium ion transmembrane transport	-

Protein-Protein Interaction

BioGRID:2 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
UBC	KCNN4	109984	18227067	Affinity Capture-Western
UBC	KCNN4	113164	18227067	Affinity Capture-Western

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:1277957
Data Attributes: MGI curated and HomoloGene calculated

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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