AutismKB 2.0

Annotation Details for KDR


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Basic Information Top
Gene Symbol:KDR ( CD309,FLK1,VEGFR,VEGFR2 )
Gene Full Name: kinase insert domain receptor (a type III receptor tyrosine kinase)
Band: 4q12
Quick LinksEntrez ID:3791; OMIM: 191306; Uniprot ID:VGFR2_HUMAN; ENSEMBL ID: ENSG00000128052; HGNC ID: 6307
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IEA-extracellular region-
GO:0005634IEA-nucleus-
GO:0005768IDA-endosome23262137
GO:0005769ISS-early endosome-
GO:0005783IDA-endoplasmic reticulum23529610
GO:0005794IDA-Golgi apparatus23262137
GO:0005886IDA-plasma membrane23262137
GO:0005886ISS-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane10102632
GO:0030054ISS-cell junction-
GO:0045121IDA-membrane raft23262137
GO:0097443ISS-sorting endosome-
GO ID Evidence Qualifier GO_term References
GO:0004713EXP-protein tyrosine kinase activity7999104
GO:0004713IDA-protein tyrosine kinase activity10037737
GO:0004714TAS-transmembrane receptor protein tyrosine kinase activity1417831
GO:0004716TAS-signal transducer, downstream of receptor, with protein tyrosine kinase activity10022831
GO:0005021IDA-vascular endothelial growth factor-activated receptor activity1417831
GO:0005178IPI-integrin binding10022831
GO:0005515IPI-protein binding1417831
GO:0005524IEA-ATP binding-
GO:0019838IPI-growth factor binding1417831
GO:0051879TAS-Hsp90 protein binding19267251
GO ID Evidence Qualifier GO_term References
GO:0001525TAS-angiogenesis10022831
GO:0001570ISS-vasculogenesis-
GO:0001934IDA-positive regulation of protein phosphorylation19033661
GO:0001938IMP-positive regulation of endothelial cell proliferation10022831
GO:0002042ISS-cell migration involved in sprouting angiogenesis-
GO:0003158ISS-endothelium development-
GO:0007169TAS-transmembrane receptor protein tyrosine kinase signaling pathway1417831
GO:0008284IDA-positive regulation of cell proliferation7929439
GO:0008284IMP-positive regulation of cell proliferation15215251
GO:0008360IDA-regulation of cell shape7929439
GO:0010595IMP-positive regulation of endothelial cell migration10022831
GO:0014068IDA-positive regulation of phosphatidylinositol 3-kinase signaling9804796
GO:0016032IEA-viral process-
GO:0016239IGI-positive regulation of macroautophagy23798385
GO:0018108IDA-peptidyl-tyrosine phosphorylation10037737
GO:0023014IEA-signal transduction by protein phosphorylation-
GO:0030198TAS-extracellular matrix organization-
GO:0030335IDA-positive regulation of cell migration7929439
GO:0030335IMP-positive regulation of cell migration15215251
GO:0035162ISS-embryonic hemopoiesis-
GO:0035584IMP-calcium-mediated signaling using intracellular calcium source15215251
GO:0035924IDA-cellular response to vascular endothelial growth factor stimulus10102632
GO:0035924IMP-cellular response to vascular endothelial growth factor stimulus15215251
GO:0038033IDA-positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway21885851
GO:0038083ISS-peptidyl-tyrosine autophosphorylation-
GO:0043066IMP-negative regulation of apoptotic process15215251
GO:0043410IDA-positive regulation of MAPK cascade11387210
GO:0045766IMP-positive regulation of angiogenesis15215251
GO:0046777IDA-protein autophosphorylation10037737
GO:0048010IDA-vascular endothelial growth factor receptor signaling pathway10102632
GO:0048010IMP-vascular endothelial growth factor receptor signaling pathway23529610
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0050927IDA-positive regulation of positive chemotaxis7929439
GO:0051770IDA-positive regulation of nitric-oxide synthase biosynthetic process10600473
GO:0051770IMP-positive regulation of nitric-oxide synthase biosynthetic process9837777
GO:0051894IDA-positive regulation of focal adhesion assembly12820653
GO:0051901IGI-positive regulation of mitochondrial depolarization23798385
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade15215251
GO:0090141IGI-positive regulation of mitochondrial fission23798385
GO:2000352IDA-negative regulation of endothelial cell apoptotic process9804796
GO:2001214ISS-positive regulation of vasculogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KDRACP110656810608891 Two-hybrid
KDRACP110999210608891 Two-hybrid
KDRANXA510680510329451 Reconstituted Complex; Two-hybrid
KDRANXA510999210329451 Reconstituted Complex; Two-hybrid
KDRCBL10731517372230 Reconstituted Complex
KDRCBL10999217372230 Reconstituted Complex
KDRCDH510743811950700 Affinity Capture-Western
KDRCDH510999211950700 Affinity Capture-Western
KDRFIGF1085679435229 Reconstituted Complex
KDRFIGF1099929435229 Reconstituted Complex
KDRFLT110999212796773 Biochemical Activity
KDRFLT110860912796773 Biochemical Activity
KDRGRB210914210319320 Affinity Capture-Western
KDRGRB210999210319320 Affinity Capture-Western
KDRGRB1010999211494124 Two-hybrid
KDRGRB1010914411494124 Two-hybrid
PLCG1KDR1113519398617 Reconstituted Complex
PLCG1KDR1099929398617 Reconstituted Complex
RASA1KDR11185610319320 Affinity Capture-Western
RASA1KDR10999210319320 Affinity Capture-Western
SHC1KDR10999210319320 11950700 Affinity Capture-Western
SHC1KDR11236110319320 11950700 Affinity Capture-Western
SHC2KDR11730210749680 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHC2KDR10999210749680 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
COL18A1KDR12331112029087 Reconstituted Complex
COL18A1KDR10999212029087 Reconstituted Complex
VEGFAKDR11326512716911 Biochemical Activity
VEGFAKDR10999212716911 Biochemical Activity
PLXNA1KDR10999214977921 Affinity Capture-Western
PLXNA1KDR11137514977921 Affinity Capture-Western
SHBKDR11235815026417 Affinity Capture-Western
SHBKDR10999215026417 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96683
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041001-112'