AutismKB 2.0

Annotation Details for KIT


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Basic Information Top
Gene Symbol:KIT ( C-Kit,CD117,PBT,SCFR )
Gene Full Name: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Band: 4q12
Quick LinksEntrez ID:3815; OMIM: 164920; Uniprot ID:KIT_HUMAN; ENSEMBL ID: ENSG00000157404; HGNC ID: 6342
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001669IEA-acrosomal vesicle-
GO:0005615IDA-extracellular space14625290
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005911IEA-cell-cell junction-
GO:0009897IEA-external side of plasma membrane-
GO:0009898IEA-cytoplasmic side of plasma membrane-
GO:0016021IEA-integral component of membrane-
GO:0042629IEA-mast cell granule-
GO ID Evidence Qualifier GO_term References
GO:0002020IEA-protease binding-
GO:0004713TAS-protein tyrosine kinase activity1717985
GO:0004714IDA-transmembrane receptor protein tyrosine kinase activity21640708
GO:0004716IEA-signal transducer, downstream of receptor, with protein tyrosine kinase activity-
GO:0005020IEA-stem cell factor receptor activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding1382595
GO:0005524IEA-ATP binding-
GO:0019955IDA-cytokine binding21640708
GO:0042803IPI-protein homodimerization activity21640708
GO:0046872IEA-metal ion binding-
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000187IDA-activation of MAPK activity21640708
GO:0001541ISS-ovarian follicle development-
GO:0002318IEA-myeloid progenitor cell differentiation-
GO:0002320IEA-lymphoid progenitor cell differentiation-
GO:0002327ISS-immature B cell differentiation-
GO:0002371ISS-dendritic cell cytokine production-
GO:0002551IDA-mast cell chemotaxis20100931
GO:0006357TAS-regulation of transcription from RNA polymerase II promoter-
GO:0006687IEA-glycosphingolipid metabolic process-
GO:0006954ISS-inflammatory response-
GO:0007165TAS-signal transduction9990072
GO:0007283ISS-spermatogenesis-
GO:0007283TAS-spermatogenesis16129412
GO:0007286IEA-spermatid development-
GO:0008284IEA-positive regulation of cell proliferation-
GO:0008354IEA-germ cell migration-
GO:0008360ISS-regulation of cell shape-
GO:0008542IEA-visual learning-
GO:0008584IEP-male gonad development17848411
GO:0010628IEA-positive regulation of gene expression-
GO:0010863TAS-positive regulation of phospholipase C activity16129412
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0014068TAS-positive regulation of phosphatidylinositol 3-kinase signaling16129412
GO:0018108IDA-peptidyl-tyrosine phosphorylation21640708
GO:0019221IDA-cytokine-mediated signaling pathway21640708
GO:0019827TAS-stem cell population maintenance21057534
GO:0030032ISS-lamellipodium assembly-
GO:0030097TAS-hemopoiesis16129412
GO:0030217ISS-T cell differentiation-
GO:0030218ISS-erythrocyte differentiation-
GO:0030318ISS-melanocyte differentiation-
GO:0030318TAS-melanocyte differentiation21057534
GO:0030335IEA-positive regulation of cell migration-
GO:0031274IEA-positive regulation of pseudopodium assembly-
GO:0031532IDA-actin cytoskeleton reorganization1721869
GO:0032762IDA-mast cell cytokine production20100931
GO:0035019IEA-somatic stem cell population maintenance-
GO:0035162ISS-embryonic hemopoiesis-
GO:0035234IEA-ectopic germ cell programmed cell death-
GO:0035701IEA-hematopoietic stem cell migration-
GO:0035855ISS-megakaryocyte development-
GO:0038093IDA-Fc receptor signaling pathway20100931
GO:0038109IDA-Kit signaling pathway17662946
GO:0038162ISS-erythropoietin-mediated signaling pathway-
GO:0042127TAS-regulation of cell proliferation16129412
GO:0042531IMP-positive regulation of tyrosine phosphorylation of STAT protein21135090
GO:0043069IEA-negative regulation of programmed cell death-
GO:0043303IMP-mast cell degranulation20100931
GO:0043410IMP-positive regulation of MAPK cascade21640708
GO:0043473ISS-pigmentation-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043552TAS-positive regulation of phosphatidylinositol 3-kinase activity16129412
GO:0045747IEA-positive regulation of Notch signaling pathway-
GO:0046427IMP-positive regulation of JAK-STAT cascade21135090
GO:0046777IDA-protein autophosphorylation21640708
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048070IEA-regulation of developmental pigmentation-
GO:0048103IEA-somatic stem cell division-
GO:0048170IEA-positive regulation of long-term neuronal synaptic plasticity-
GO:0048565ISS-digestive tract development-
GO:0048863ISS-stem cell differentiation-
GO:0050673IEA-epithelial cell proliferation-
GO:0050910ISS-detection of mechanical stimulus involved in sensory perception of sound-
GO:0051091IMP-positive regulation of sequence-specific DNA binding transcription factor activity21135090
GO:0060326IDA-cell chemotaxis1721869
GO:0060374ISS-mast cell differentiation-
GO:0060374TAS-mast cell differentiation16129412
GO:0070662TAS-mast cell proliferation21057534
GO:0097067IEA-cellular response to thyroid hormone stimulus-
GO:0097324ISS-melanocyte migration-
GO:0097326ISS-melanocyte adhesion-
GO:1905065IDA-positive regulation of vascular smooth muscle cell differentiation19088079
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KITBCR1100158757502 Affinity Capture-Western
KITBCR1070838757502 Affinity Capture-Western
KITCBL10731515315962 Affinity Capture-Western
KITCBL11001515315962 Affinity Capture-Western
KITCBLB11001512177062 Affinity Capture-Western
KITCBLB10731612177062 Affinity Capture-Western
KITCD911001512036870 Affinity Capture-Western
KITCD910736612036870 Affinity Capture-Western
KITCD6311001512036870 Affinity Capture-Western
KITCD6310740512036870 Affinity Capture-Western
KITCD8111001512036870 Affinity Capture-Western
KITCD8110741312036870 Affinity Capture-Western
KITCLTC11001510477727 Affinity Capture-Western
KITCLTC10762310477727 Affinity Capture-Western
KITCRKL1077899092574 11071635 Affinity Capture-Western; Reconstituted Complex
KITCRKL1100159092574 11071635 Affinity Capture-Western; Reconstituted Complex
KITDOK111001511825908 Affinity Capture-Western; Reconstituted Complex
KITDOK110813111825908 Affinity Capture-Western; Reconstituted Complex
KITGRB21091428647802 10022833 10377264 17904548 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KITGRB21100158647802 10022833 10377264 17904548 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KITGRB711001510377264 Reconstituted Complex
KITGRB710914310377264 Reconstituted Complex
KITGRB1011001511809791 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KITGRB1010914411809791 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KITINPP5D10984711071635 Reconstituted Complex
KITINPP5D11001511071635 Reconstituted Complex
KITJAK21099207527392 Affinity Capture-Western
KITJAK21100157527392 Affinity Capture-Western
KITLGKIT1100151375232 7680037 Affinity Capture-Western; Reconstituted Complex
KITLGKIT1104101375232 7680037 Affinity Capture-Western; Reconstituted Complex
PIK3R1KIT1100157509796 10022833 11071635 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIK3R1KIT1113137509796 10022833 11071635 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PTPN11KIT1100157523381 9528781 Affinity Capture-Western; Reconstituted Complex
PTPN11KIT1117457523381 9528781 Affinity Capture-Western; Reconstituted Complex
TECKIT1100157526158 11071635 Affinity Capture-Western; Reconstituted Complex
TECKIT1128657526158 11071635 Affinity Capture-Western; Reconstituted Complex
MATKKIT1100157536744 9038210 Reconstituted Complex
MATKKIT1103157536744 9038210 Reconstituted Complex
PLCG1KIT1100157536744 11071635 Reconstituted Complex
PLCG1KIT1113517536744 11071635 Reconstituted Complex
PTPN6KIT1117427684496 9528781 Affinity Capture-Western; Reconstituted Complex
PTPN6KIT1100157684496 9528781 Affinity Capture-Western; Reconstituted Complex
GRAPKIT1159738647802 Reconstituted Complex
GRAPKIT1100158647802 Reconstituted Complex
LYNKIT1100159341198 11825908 Affinity Capture-Western; Reconstituted Complex
LYNKIT1102459341198 11825908 Affinity Capture-Western; Reconstituted Complex
STAT1KIT1100159355737 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
STAT1KIT1126499355737 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
LCKKIT1100159788619 Affinity Capture-Western
LCKKIT1101249788619 Affinity Capture-Western
SOCS1KIT11420310022833 Affinity Capture-Western; Two-hybrid
SOCS1KIT11001510022833 Affinity Capture-Western; Two-hybrid
PIK3R2KIT11001510022833 Two-hybrid
PIK3R2KIT11131410022833 Two-hybrid
RFC1KIT11001510353443 Affinity Capture-Western
RFC1KIT11191310353443 Affinity Capture-Western
PTPROKIT11001510397721 Affinity Capture-Western
PTPROKIT11176410397721 Affinity Capture-Western
MPDZKIT11001511018522 Reconstituted Complex; Two-hybrid
MPDZKIT11430711018522 Reconstituted Complex; Two-hybrid
YES1KIT11001511071635 Reconstituted Complex
YES1KIT11335711071635 Reconstituted Complex
SH3KBP1KIT11902912177062 Affinity Capture-Western
SH3KBP1KIT11001512177062 Affinity Capture-Western
UBCKIT11001515315962 Affinity Capture-Western
UBCKIT11316415315962 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96677
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050916-2'