AutismKB 2.0

Annotation Details for KRAS


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Basic Information Top
Gene Symbol:KRAS ( C-K-RAS,K-RAS2A,K-RAS2B,K-RAS4A,K-RAS4B,KI-RAS,KRAS1,KRAS2,NS,NS3,RASK2 )
Gene Full Name: v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Band: 12p12.1
Quick LinksEntrez ID:3845; OMIM: 190070; Uniprot ID:RASK_HUMAN; ENSEMBL ID: ENSG00000133703; HGNC ID: 6407
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm23698361
GO:0005739IEA-mitochondrion-
GO:0005829IEA-cytosol-
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0016020IDA-membrane19946888
GO:0031234IDA-extrinsic component of cytoplasmic side of plasma membrane23698361
GO:0045121IEA-membrane raft-
GO ID Evidence Qualifier GO_term References
GO:0003924IEA-GTPase activity-
GO:0005515IPI-protein binding12732644
GO:0005525IEA-GTP binding-
GO:0019002IEA-GMP binding-
GO:0019003IEA-GDP binding-
GO:0030275IEA-LRR domain binding-
GO:0032403IDA-protein complex binding23209302
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001889IEA-liver development-
GO:0001934IMP-positive regulation of protein phosphorylation22065586
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0007173TAS-epidermal growth factor receptor signaling pathway-
GO:0007265TAS-Ras protein signal transduction-
GO:0007411TAS-axon guidance-
GO:0007565IEA-female pregnancy-
GO:0008284IMP-positive regulation of cell proliferation23698361
GO:0008542IEA-visual learning-
GO:0010628IMP-positive regulation of gene expression22065586
GO:0019221IEA-cytokine-mediated signaling pathway-
GO:0021897IEA-forebrain astrocyte development-
GO:0030036IEA-actin cytoskeleton organization-
GO:0031647IMP-regulation of protein stability24623306
GO:0032228IEA-regulation of synaptic transmission, GABAergic-
GO:0035022IEA-positive regulation of Rac protein signal transduction-
GO:0035900IEA-response to isolation stress-
GO:0038002IEA-endocrine signaling-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0038128TAS-ERBB2 signaling pathway-
GO:0043406IEA-positive regulation of MAP kinase activity-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0045596IEA-negative regulation of cell differentiation-
GO:0048169IEA-regulation of long-term neuronal synaptic plasticity-
GO:0048873IEA-homeostasis of number of cells within a tissue-
GO:0050900TAS-leukocyte migration-
GO:0051000IEA-positive regulation of nitric-oxide synthase activity-
GO:0051092IEA-positive regulation of NF-kappaB transcription factor activity-
GO:0051146IEA-striated muscle cell differentiation-
GO:0051384IEA-response to glucocorticoid-
GO:0051385IEA-response to mineralocorticoid-
GO:0060441IEA-epithelial tube branching involved in lung morphogenesis-
GO:2000774IEA-positive regulation of cellular senescence-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KRASEPB421083523276554 Reconstituted Complex
KRASEPB421100433276554 Reconstituted Complex
KRASHNRNPC11004316189514 Two-hybrid
KRASHNRNPC10942416189514 Two-hybrid
RALGDSKRAS1100437809086 10783161 Reconstituted Complex; Two-hybrid
RALGDSKRAS1118367809086 10783161 Reconstituted Complex; Two-hybrid
PIK3CGKRAS11131210542052 Affinity Capture-Western; Reconstituted Complex
PIK3CGKRAS11004310542052 Affinity Capture-Western; Reconstituted Complex
RAF1KRAS11183110783161 10882715 Affinity Capture-Western; Two-hybrid
RAF1KRAS11004310783161 10882715 Affinity Capture-Western; Two-hybrid
PIK3CAKRAS11004310783161 Two-hybrid
PIK3CAKRAS11130810783161 Two-hybrid
SHOC2KRAS11372910783161 Two-hybrid
SHOC2KRAS11004310783161 Two-hybrid
RASSF5KRAS12368911857081 Reconstituted Complex
RASSF5KRAS11004311857081 Reconstituted Complex
RAP1GDS1KRAS11184511948427 Two-hybrid
RAP1GDS1KRAS11004311948427 Two-hybrid
RASSF2KRAS11511512732644 Affinity Capture-Western; Reconstituted Complex
RASSF2KRAS11004312732644 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96680
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040808-67'