AutismKB 2.0

Annotation Details for RHOB


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Basic Information Top
Gene Symbol:RHOB ( ARH6,ARHB,MST081,MSTP081,RHOH6 )
Gene Full Name: ras homolog gene family, member B
Band: 2p24.1
Quick LinksEntrez ID:388; OMIM: 165370; Uniprot ID:RHOB_HUMAN; ENSEMBL ID: ENSG00000143878; HGNC ID: 668
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634ISS-nucleus-
GO:0005769IEA-early endosome-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane15226397
GO:0005886TAS-plasma membrane-
GO:0005925IDA-focal adhesion21423176
GO:0010008IDA-endosome membrane15226397
GO:0010008TAS-endosome membrane-
GO:0031902IEA-late endosome membrane-
GO:0032154IDA-cleavage furrow16236794
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0003924TAS-GTPase activity3888408
GO:0005515IPI-protein binding19637314
GO:0005525TAS-GTP binding1400319
GO:0019003IEA-GDP binding-
GO ID Evidence Qualifier GO_term References
GO:0000910IMP-cytokinesis16236794
GO:0001525IEA-angiogenesis-
GO:0006886IEA-intracellular protein transport-
GO:0006915TAS-apoptotic process19637314
GO:0007155ISS-cell adhesion-
GO:0007266TAS-Rho protein signal transduction3888408
GO:0008333IDA-endosome to lysosome transport10508588
GO:0010595IMP-positive regulation of endothelial cell migration21347332
GO:0030154IEA-cell differentiation-
GO:0030168TAS-platelet activation-
GO:0030334IGI-regulation of cell migration20460403
GO:0030336IDA-negative regulation of cell migration20460403
GO:0043065IMP-positive regulation of apoptotic process21373644
GO:0043065ISS-positive regulation of apoptotic process-
GO:0045766ISS-positive regulation of angiogenesis-
GO:0045786ISS-negative regulation of cell cycle-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0061154IMP-endothelial tube morphogenesis21347332
GO:0070301IDA-cellular response to hydrogen peroxide21373644
GO:0071479IDA-cellular response to ionizing radiation21373644
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CITRHOB1068818543060 Far Western; Two-hybrid
CITRHOB1162908543060 Far Western; Two-hybrid
ARHGDIGRHOB1068918939998 Two-hybrid
ARHGDIGRHOB1068818939998 Two-hybrid
PDE6DRHOB11117311786539 Two-hybrid
PDE6DRHOB10688111786539 Two-hybrid
ARHGEF3RHOB11911512221096 Biochemical Activity; Reconstituted Complex
ARHGEF3RHOB10688112221096 Biochemical Activity; Reconstituted Complex
RHPN2RHOB12452112473120 Affinity Capture-Western; Two-hybrid
RHPN2RHOB10688112473120 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107949
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018