AutismKB 2.0

Annotation Details for LCK


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Basic Information Top
Gene Symbol:LCK ( LSK,YT16,p56lck,pp58lck )
Gene Full Name: lymphocyte-specific protein tyrosine kinase
Band: 1p35.2
Quick LinksEntrez ID:3932; OMIM: 153390; Uniprot ID:LCK_HUMAN; ENSEMBL ID: ENSG00000182866; HGNC ID: 6524
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000242IDA-pericentriolar material7513706
GO:0000242ISS-pericentriolar material-
GO:0001772IDA-immunological synapse20007709
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane12150984
GO:0005886TAS-plasma membrane-
GO:0031234IBA-extrinsic component of cytoplasmic side of plasma membrane-
GO:0045121IDA-membrane raft12150984
GO:0045121ISS-membrane raft-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0001784IPI-phosphotyrosine residue binding20624904
GO:0001948IPI-glycoprotein binding7513706
GO:0004713EXP-protein tyrosine kinase activity1381360
GO:0004713IDA-protein tyrosine kinase activity214242
GO:0004713IMP-protein tyrosine kinase activity8681956
GO:0004713ISS-protein tyrosine kinase activity-
GO:0004713TAS-protein tyrosine kinase activity-
GO:0004715IBA-non-membrane spanning protein tyrosine kinase activity-
GO:0004722IDA-protein serine/threonine phosphatase activity8506364
GO:0004722ISS-protein serine/threonine phosphatase activity-
GO:0005515IPI-protein binding7507203
GO:0005524IEA-ATP binding-
GO:0008022IPI-protein C-terminus binding16245368
GO:0016301TAS-kinase activity-
GO:0019901IPI-protein kinase binding8618896
GO:0019903IPI-protein phosphatase binding22080863
GO:0042169IPI-SH2 domain binding7852312
GO:0042169ISS-SH2 domain binding-
GO:0042608IPI-T cell receptor binding8681956
GO:0042609IPI-CD4 receptor binding7486703
GO:0042610IPI-CD8 receptor binding2470098
GO:0042802IPI-identical protein binding17118402
GO:0043548IPI-phosphatidylinositol 3-kinase binding7504174
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO:0051117IPI-ATPase binding15671290
GO ID Evidence Qualifier GO_term References
GO:0006468IDA-protein phosphorylation214242
GO:0006470IEA-protein dephosphorylation-
GO:0006882IEP-cellular zinc ion homeostasis11739864
GO:0006882ISS-cellular zinc ion homeostasis-
GO:0006919IDA-activation of cysteine-type endopeptidase activity involved in apoptotic process16116473
GO:0006919ISS-activation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0007169IBA-transmembrane receptor protein tyrosine kinase signaling pathway-
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0016032IEA-viral process-
GO:0016477IBA-cell migration-
GO:0018108IMP-peptidyl-tyrosine phosphorylation8681956
GO:0030097NAS-hemopoiesis12884910
GO:0030168TAS-platelet activation-
GO:0030217IMP-T cell differentiation1579166
GO:0030217ISS-T cell differentiation-
GO:0031295TAS-T cell costimulation-
GO:0038083IBA-peptidyl-tyrosine autophosphorylation-
GO:0042127IBA-regulation of cell proliferation-
GO:0042493IDA-response to drug16116473
GO:0042493ISS-response to drug-
GO:0045087IBA-innate immune response-
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0050690TAS-regulation of defense response to virus by virus-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0050853IBA-B cell receptor signaling pathway-
GO:0050862NAS-positive regulation of T cell receptor signaling pathway12614355
GO:0050870IDA-positive regulation of T cell activation8943371
GO:0050870ISS-positive regulation of T cell activation-
GO:0050900TAS-leukocyte migration-
GO:0051209ISS-release of sequestered calcium ion into cytosol-
GO:0051249NAS-regulation of lymphocyte activation7852312
GO:2001244IMP-positive regulation of intrinsic apoptotic signaling pathway16116473
GO:2001244ISS-positive regulation of intrinsic apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LCKADAM1011012411741929 Affinity Capture-Western
LCKADAM1010661611741929 Affinity Capture-Western
LCKFAS1068518864141 Reconstituted Complex
LCKFAS1101248864141 Reconstituted Complex
LCKFASLG11012411741599 Reconstituted Complex
LCKFASLG10685211741599 Reconstituted Complex
LCKAXL1101249178760 Far Western
LCKAXL1070369178760 Far Western
LCKCBL10731511904433 Affinity Capture-Western
LCKCBL11012411904433 Affinity Capture-Western
LCKCD21101248551220 Affinity Capture-Western; Reconstituted Complex
LCKCD21073528551220 Affinity Capture-Western; Reconstituted Complex
LCKCD410735811854499 12007789 Affinity Capture-Western
LCKCD411012411854499 12007789 Affinity Capture-Western
LCKMS4A11101247545683 Affinity Capture-Western
LCKMS4A11073697545683 Affinity Capture-Western
LCKCD441101248576267 9573028 Affinity Capture-Western; Co-fractionation
LCKCD441073988576267 9573028 Affinity Capture-Western; Co-fractionation
LCKCD4811012412007789 Affinity Capture-Western
LCKCD4810740012007789 Affinity Capture-Western
LCKCTLA41078759712716 Affinity Capture-Western
LCKCTLA41101249712716 Affinity Capture-Western
LCKCTNND111012412835311 Biochemical Activity
LCKCTNND110788112835311 Biochemical Activity
LCKDLG11080839341123 Affinity Capture-Western; Reconstituted Complex
LCKDLG11101249341123 Affinity Capture-Western; Reconstituted Complex
LCKPTK2B1084809091579 Affinity Capture-Western
LCKPTK2B1101249091579 Affinity Capture-Western
LCKKIT1100159788619 Affinity Capture-Western
LCKKIT1101249788619 Affinity Capture-Western
THY1LCK1101241351058 Affinity Capture-Western
THY1LCK1129261351058 Affinity Capture-Western
ZAP70LCK1133677539035 10318843 Affinity Capture-Western
ZAP70LCK1101247539035 10318843 Affinity Capture-Western
SYKLCK1101247539035 Affinity Capture-Western; Reconstituted Complex
SYKLCK1127177539035 Affinity Capture-Western; Reconstituted Complex
PTPN6LCK1117428114715 10617656 11294838 Biochemical Activity; Reconstituted Complex
PTPN6LCK1101248114715 10617656 11294838 Biochemical Activity; Reconstituted Complex
PIK3CALCK1101248246987 14583609 Affinity Capture-Western; Reconstituted Complex
PIK3CALCK1113088246987 14583609 Affinity Capture-Western; Reconstituted Complex
PI4KALCK1113158246987 Reconstituted Complex
PI4KALCK1101248246987 Reconstituted Complex
PIK3R1LCK1101248294442 Reconstituted Complex
PIK3R1LCK1113138294442 Reconstituted Complex
PTPRCLCK1117528473339 8576115 15085197 Affinity Capture-Western; Reconstituted Complex
PTPRCLCK1101248473339 8576115 15085197 Affinity Capture-Western; Reconstituted Complex
SQSTM1LCK1143978650207 Reconstituted Complex
SQSTM1LCK1101248650207 Reconstituted Complex
NEDD9LCK1108168879209 Affinity Capture-Western
NEDD9LCK1101248879209 Affinity Capture-Western
NR2F2LCK1128848910285 Reconstituted Complex; Two-hybrid
NR2F2LCK1101248910285 Reconstituted Complex; Two-hybrid
RAF1LCK1118318939988 Affinity Capture-Western
RAF1LCK1101248939988 Affinity Capture-Western
BCAR1LCK1149349020138 Reconstituted Complex
BCAR1LCK1101249020138 Reconstituted Complex
KHDRBS1LCK1159009045636 Affinity Capture-Western
KHDRBS1LCK1101249045636 Affinity Capture-Western
SKAP1LCK1101249195899 Reconstituted Complex
SKAP1LCK1141849195899 Reconstituted Complex
PXNLCK1117879488700 Affinity Capture-Western
PXNLCK1101249488700 Affinity Capture-Western
PECAM1LCK1112019624175 Biochemical Activity
PECAM1LCK1101249624175 Biochemical Activity
SIT1LCK11808810209036 Affinity Capture-Western
SIT1LCK11012410209036 Affinity Capture-Western
PRKCQLCK11157410383400 Two-hybrid
PRKCQLCK11012410383400 Two-hybrid
UBE3ALCK11318510449731 Reconstituted Complex; Two-hybrid
UBE3ALCK11012410449731 Reconstituted Complex; Two-hybrid
TRAT1LCK11915410790433 Reconstituted Complex
TRAT1LCK11012410790433 Reconstituted Complex
PAG1LCK12093110790433 Reconstituted Complex
PAG1LCK11012410790433 Reconstituted Complex
SH2B3LCK11012410799879 Affinity Capture-Western
SH2B3LCK11533610799879 Affinity Capture-Western
RASA1LCK11012411389730 Biochemical Activity
RASA1LCK11185611389730 Biochemical Activity
ARHGAP17LCK12042411431473 Reconstituted Complex
ARHGAP17LCK11012411431473 Reconstituted Complex
ADAM15LCK11428711741929 Affinity Capture-Western; Reconstituted Complex
ADAM15LCK11012411741929 Affinity Capture-Western; Reconstituted Complex
TRPV4LCK12188312538589 Affinity Capture-Western
TRPV4LCK11012412538589 Affinity Capture-Western
UBCLCK11316412746907 Affinity Capture-Western
UBCLCK11012412746907 Affinity Capture-Western
NOTCH1LCK11091314583609 Affinity Capture-Western
NOTCH1LCK11012414583609 Affinity Capture-Western
UNC119LCK11454814757743 Affinity Capture-Western; Reconstituted Complex
UNC119LCK11012414757743 Affinity Capture-Western; Reconstituted Complex
IKBKGLCK11408920098747 Reconstituted Complex
IKBKGLCK11012420098747 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
LCKCD8B30055015980863 CD8-Beta interacts with Lck.
LCKDNM221652215696170 An unspecified isoform of Dyn2 interacts with Lck. This interaction was modeled on a demonstrated interaction between human Dyn2 and Lck from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
LCKhCV1895446 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:96756
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040617-1'