AutismKB 2.0

Annotation Details for LEP


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Basic Information Top
Gene Symbol:LEP ( FLJ94114,OB,OBS )
Gene Full Name: leptin
Band: 7q32.1
Quick LinksEntrez ID:3952; OMIM: 164160; Uniprot ID:LEP_HUMAN; ENSEMBL ID: ENSG00000174697; HGNC ID: 6553
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IBA-extracellular space-
GO:0005615ISS-extracellular space-
GO:0005737IEA-cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0005179IBA-hormone activity-
GO:0008083IEA-growth factor activity-
GO:0051428IBA-peptide hormone receptor binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001525IDA-angiogenesis19910644
GO:0001542IEA-ovulation from ovarian follicle-
GO:0001666IEA-response to hypoxia-
GO:0001890IDA-placenta development17957153
GO:0001936IDA-regulation of endothelial cell proliferation11460888
GO:0002021IEA-response to dietary excess-
GO:0003300IEA-cardiac muscle hypertrophy-
GO:0006006IEA-glucose metabolic process-
GO:0006111IEA-regulation of gluconeogenesis-
GO:0006112IBA-energy reserve metabolic process-
GO:0006114IEA-glycerol biosynthetic process-
GO:0006629IBA-lipid metabolic process-
GO:0006635IEA-fatty acid beta-oxidation-
GO:0006909IEA-phagocytosis-
GO:0007260IBA-tyrosine phosphorylation of STAT protein-
GO:0007565IEA-female pregnancy-
GO:0007623IEA-circadian rhythm-
GO:0008203IEA-cholesterol metabolic process-
GO:0008206IEA-bile acid metabolic process-
GO:0008217IEA-regulation of blood pressure-
GO:0008343ISS-adult feeding behavior-
GO:0010507IDA-negative regulation of autophagy25060689
GO:0010888IEA-negative regulation of lipid storage-
GO:0014068IDA-positive regulation of phosphatidylinositol 3-kinase signaling24340098
GO:0014068ISS-positive regulation of phosphatidylinositol 3-kinase signaling-
GO:0014823IEA-response to activity-
GO:0019953IMP-sexual reproduction8589726
GO:0021954IEA-central nervous system neuron development-
GO:0030073IEA-insulin secretion-
GO:0030217ISS-T cell differentiation-
GO:0030300IEA-regulation of intestinal cholesterol absorption-
GO:0032008IDA-positive regulation of TOR signaling25060689
GO:0032099ISS-negative regulation of appetite-
GO:0032310IDA-prostaglandin secretion19688109
GO:0032355IEA-response to estradiol-
GO:0032615IEA-interleukin-12 production-
GO:0032760IEA-positive regulation of tumor necrosis factor production-
GO:0032814IDA-regulation of natural killer cell activation12504075
GO:0032817IDA-regulation of natural killer cell proliferation12504075
GO:0032868IBA-response to insulin-
GO:0033197IEA-response to vitamin E-
GO:0033210ISS-leptin-mediated signaling pathway-
GO:0033686IEA-positive regulation of luteinizing hormone secretion-
GO:0035360IEA-positive regulation of peroxisome proliferator activated receptor signaling pathway-
GO:0035630IEA-bone mineralization involved in bone maturation-
GO:0038108IBA-negative regulation of appetite by leptin-mediated signaling pathway-
GO:0038108ISS-negative regulation of appetite by leptin-mediated signaling pathway-
GO:0042102IDA-positive regulation of T cell proliferation25060689
GO:0042269IDA-regulation of natural killer cell mediated cytotoxicity12504075
GO:0042445IEA-hormone metabolic process-
GO:0042593IEA-glucose homeostasis-
GO:0042755IEA-eating behavior-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043270IEA-positive regulation of ion transport-
GO:0043410IDA-positive regulation of MAPK cascade24340098
GO:0043410ISS-positive regulation of MAPK cascade-
GO:0044320IDA-cellular response to leptin stimulus17344214
GO:0045471IEA-response to ethanol-
GO:0045639IEA-positive regulation of myeloid cell differentiation-
GO:0045765IDA-regulation of angiogenesis11460888
GO:0045906IEA-negative regulation of vasoconstriction-
GO:0046325IDA-negative regulation of glucose import24340098
GO:0046427IDA-positive regulation of JAK-STAT cascade17344214
GO:0046628IEA-positive regulation of insulin receptor signaling pathway-
GO:0046850ISS-regulation of bone remodeling-
GO:0046881IEA-positive regulation of follicle-stimulating hormone secretion-
GO:0048639IDA-positive regulation of developmental growth17957153
GO:0050796IEA-regulation of insulin secretion-
GO:0050810IEA-regulation of steroid biosynthetic process-
GO:0050892IDA-intestinal absorption24340098
GO:0050901IEA-leukocyte tethering or rolling-
GO:0050999IDA-regulation of nitric-oxide synthase activity15899045
GO:0051726IDA-regulation of cell cycle17344214
GO:0051897ISS-positive regulation of protein kinase B signaling-
GO:0060587IEA-regulation of lipoprotein lipid oxidation-
GO:0060612IEA-adipose tissue development-
GO:0061037IEA-negative regulation of cartilage development-
GO:0070093IEA-negative regulation of glucagon secretion-
GO:0071298IEA-cellular response to L-ascorbic acid-
GO:0071300IEA-cellular response to retinoic acid-
GO:0072604IDA-interleukin-6 secretion19688109
GO:0072606IDA-interleukin-8 secretion19688109
GO:0090335ISS-regulation of brown fat cell differentiation-
GO:0098868ISS-bone growth-
GO:1900015IDA-regulation of cytokine production involved in inflammatory response19688109
GO:1900745IDA-positive regulation of p38MAPK cascade24340098
GO:1904651IEA-positive regulation of fat cell apoptotic process-
GO:1990051IDA-activation of protein kinase C activity24340098
GO:2000366IBA-positive regulation of STAT protein import into nucleus-
GO:2000379IEA-positive regulation of reactive oxygen species metabolic process-
GO:2000486IEA-negative regulation of glutamine transport-
GO:2000491IEA-positive regulation of hepatic stellate cell activation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LEPA2M1101439724081 Reconstituted Complex
LEPA2M1065249724081 Reconstituted Complex
LEPCLU10760312824284 Affinity Capture-Western; Reconstituted Complex
LEPCLU11014312824284 Affinity Capture-Western; Reconstituted Complex
LEPHK311014311068878 Reconstituted Complex; Two-hybrid
LEPHK310934811068878 Reconstituted Complex; Two-hybrid
STAT3LEP11014312824284 Reconstituted Complex
STAT3LEP11265112824284 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104663
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041210-183'