AutismKB 2.0

Annotation Details for LEPR


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Basic Information Top
Gene Symbol:LEPR ( CD295,DKFZp686B1731,OBR )
Gene Full Name: leptin receptor
Band: 1p31.3
Quick LinksEntrez ID:3953; OMIM: 601007; Uniprot ID:LEPR_HUMAN; ENSEMBL ID: ENSG00000116678; HGNC ID: 6554
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IEA-extracellular region-
GO:0005886TAS-plasma membrane-
GO:0016021IEA-integral component of membrane-
GO:0016323IEA-basolateral plasma membrane-
GO:0043235IDA-receptor complex23382219
GO ID Evidence Qualifier GO_term References
GO:0004888TAS-transmembrane signaling receptor activity9537324
GO:0005515IPI-protein binding11279102
GO:0038021ISS-leptin receptor activity-
GO ID Evidence Qualifier GO_term References
GO:0001525IMP-angiogenesis21771332
GO:0006112TAS-energy reserve metabolic process9537324
GO:0006909IEA-phagocytosis-
GO:0007166TAS-cell surface receptor signaling pathway9537324
GO:0007275TAS-multicellular organism development9537324
GO:0008203IEA-cholesterol metabolic process-
GO:0010507IDA-negative regulation of autophagy25060689
GO:0019953ISS-sexual reproduction-
GO:0030217ISS-T cell differentiation-
GO:0033210ISS-leptin-mediated signaling pathway-
GO:0042593ISS-glucose homeostasis-
GO:0044321ISS-response to leptin-
GO:0045721IEA-negative regulation of gluconeogenesis-
GO:0046850ISS-regulation of bone remodeling-
GO:0051346IEA-negative regulation of hydrolase activity-
GO:0060259ISS-regulation of feeding behavior-
GO:0097009ISS-energy homeostasis-
GO:0098868ISS-bone growth-
GO:2000505ISS-regulation of energy homeostasis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LEPRJAK310992111585385 Affinity Capture-Western
LEPRJAK311014411585385 Affinity Capture-Western
SNX1LEPR1125259819414 Affinity Capture-Western
SNX1LEPR1101449819414 Affinity Capture-Western
SNX2LEPR1125269819414 Affinity Capture-Western
SNX2LEPR1101449819414 Affinity Capture-Western
SNX4LEPR1142629819414 Affinity Capture-Western
SNX4LEPR1101449819414 Affinity Capture-Western
SOCS3LEPR11448811018044 Reconstituted Complex
SOCS3LEPR11014411018044 Reconstituted Complex
SNX6LEPR11014411279102 Affinity Capture-Western
SNX6LEPR12185211279102 Affinity Capture-Western
PIN1LEPR11014416169070 Two-hybrid
PIN1LEPR11131716169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104993
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080104-1'