AutismKB 2.0

Annotation Details for LGALS3


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Basic Information Top
Gene Symbol:LGALS3 ( CBP35,GAL3,GALBP,GALIG,L31,LGALS2,MAC2 )
Gene Full Name: lectin, galactoside-binding, soluble, 3
Band: 14q22.3
Quick LinksEntrez ID:3958; OMIM: 153619; Uniprot ID:LEG3_HUMAN; ENSEMBL ID: ENSG00000131981; HGNC ID: 6563
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001772IDA-immunological synapse19706535
GO:0005615IDA-extracellular space22664934
GO:0005634IDA-nucleus7682704
GO:0005681IEA-spliceosomal complex-
GO:0005737IDA-cytoplasm9447709
GO:0005743IDA-mitochondrial inner membrane19016746
GO:0005886TAS-plasma membrane-
GO:0016020IDA-membrane19946888
GO:0030667TAS-secretory granule membrane-
GO:0031012IDAcolocalizes_withextracellular matrix20551380
GO:0070062IDA-extracellular exosome19056867
GO:0101003TAS-ficolin-1-rich granule membrane-
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0005515IPI-protein binding2402511
GO:0019863IDA-IgE binding2261464
GO:0030246IEA-carbohydrate binding-
GO:0042056IDA-chemoattractant activity10925302
GO:0043236IDA-laminin binding2402511
GO ID Evidence Qualifier GO_term References
GO:0002548IDA-monocyte chemotaxis10925302
GO:0006397IEA-mRNA processing-
GO:0008380IEA-RNA splicing-
GO:0030593IDA-neutrophil chemotaxis10925302
GO:0030855IEP-epithelial cell differentiation21492153
GO:0042129IMP-regulation of T cell proliferation8692888
GO:0043312TAS-neutrophil degranulation-
GO:0045087IEA-innate immune response-
GO:0045806IDA-negative regulation of endocytosis19706535
GO:0048245IDA-eosinophil chemotaxis10925302
GO:0048246IDA-macrophage chemotaxis10925302
GO:0050860ISS-negative regulation of T cell receptor signaling pathway19706535
GO:0050918IDA-positive chemotaxis10925302
GO:0070232IDA-regulation of T cell apoptotic process8692888
GO:0071674IDA-mononuclear cell migration10925302
GO:0071677IDA-positive regulation of mononuclear cell migration10925302
GO:0090280IDA-positive regulation of calcium ion import10925302
GO:1902041IMP-regulation of extrinsic apoptotic signaling pathway via death domain receptors8692888
GO:2000521ISS-negative regulation of immunological synapse formation19706535
GO:2001189ISS-negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell19706535
GO:2001200IDANOTpositive regulation of dendritic cell differentiation16116184
GO:2001237IDA-negative regulation of extrinsic apoptotic signaling pathway22761016
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LGALS3ELN11014910536372 Affinity Capture-Western; Reconstituted Complex
LGALS3ELN10832110536372 Affinity Capture-Western; Reconstituted Complex
LGALS3FCGR2A11014910704522 Reconstituted Complex
LGALS3FCGR2A10850610704522 Reconstituted Complex
LGALS3LGALS111014911522829 Affinity Capture-Western
LGALS3LGALS111014711522829 Affinity Capture-Western
LGALS3BPLGALS31101491917996 8390986 11146440 Affinity Capture-Western; Co-purification; Reconstituted Complex
LGALS3BPLGALS31101501917996 8390986 11146440 Affinity Capture-Western; Co-purification; Reconstituted Complex
GEMIN4LGALS311910211522829 Reconstituted Complex
GEMIN4LGALS311014911522829 Reconstituted Complex
C1GALT1C1LGALS311014918695044 Reconstituted Complex
C1GALT1C1LGALS311884418695044 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:96778
  • Data Attributes: MGI curated and HomoloGene calculated
No data