AutismKB 2.0

Annotation Details for LIG3


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Basic Information Top
Gene Symbol:LIG3 ( LIG2 )
Gene Full Name: ligase III, DNA, ATP-dependent
Band: 17q12
Quick LinksEntrez ID:3980; OMIM: 600940; Uniprot ID:DNLI3_HUMAN; ENSEMBL ID: ENSG00000005156; HGNC ID: 6600
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005739IBA-mitochondrion-
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003909IDA-DNA ligase activity9809069
GO:0003909TAS-DNA ligase activity-
GO:0003910IBA-DNA ligase (ATP) activity-
GO:0005515IPI-protein binding15744309
GO:0005524IEA-ATP binding-
GO:0008270IEA-zinc ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000724TAS-double-strand break repair via homologous recombination-
GO:0006273IBANOTlagging strand elongation-
GO:0006283TAS-transcription-coupled nucleotide-excision repair-
GO:0006288IDA-base-excision repair, DNA ligation19589734
GO:0006288TAS-base-excision repair, DNA ligation-
GO:0006297TAS-nucleotide-excision repair, DNA gap filling-
GO:0006302IDA-double-strand break repair19589734
GO:0007049IEA-cell cycle-
GO:0033151IDANOTV(D)J recombination9809069
GO:0051301IEA-cell division-
GO:0071897IEA-DNA biosynthetic process-
GO:0090298IMP-negative regulation of mitochondrial DNA replication21878356
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
XRCC1LIG31133498264637 9136882 9705932 11163244 11352725 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
XRCC1LIG31101688264637 9136882 9705932 11163244 11352725 17353931 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
PNKPLIG311644011163244 17353931 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
PNKPLIG311016811163244 17353931 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
NEIL1LIG312278715260972 Far Western; Reconstituted Complex; Two-hybrid
NEIL1LIG311016815260972 Far Western; Reconstituted Complex; Two-hybrid
NCAPGLIG312208916543152 Affinity Capture-Western
NCAPGLIG311016816543152 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109152
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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