AutismKB 2.0

Annotation Details for LIMK1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LIMK1 ( LIMK )
Gene Full Name: LIM domain kinase 1
Band: 7q11.23
Quick LinksEntrez ID:3984; OMIM: 601329; Uniprot ID:LIMK1_HUMAN; ENSEMBL ID: ENSG00000106683; HGNC ID: 6613
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005737IDA-cytoplasm17512523
GO:0005794IBA-Golgi apparatus-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005925IEA-focal adhesion-
GO:0016020IEA-membrane-
GO:0016607IDA-nuclear speck-
GO:0043005IBA-neuron projection-
GO:0043005ISS-neuron projection-
GO ID Evidence Qualifier GO_term References
GO:0004672NAS-protein kinase activity8537403
GO:0004674IBA-protein serine/threonine kinase activity-
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004871IBA-signal transducer activity-
GO:0005515IPI-protein binding8940095
GO:0005524IEA-ATP binding-
GO:0031072IDA-heat shock protein binding17512523
GO:0046872IEA-metal ion binding-
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0006468IDA-protein phosphorylation17512523
GO:0006468IMP-protein phosphorylation23633677
GO:0007165TAS-signal transduction10428028
GO:0007266TAS-Rho protein signal transduction10436159
GO:0007399TAS-nervous system development8689688
GO:0030036TAS-actin cytoskeleton organization10428028
GO:0032233IDA-positive regulation of actin filament bundle assembly17512523
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0045773ISS-positive regulation of axon extension-
GO:0051444IDA-negative regulation of ubiquitin-protein transferase activity17512523
GO:0051496IBA-positive regulation of stress fiber assembly-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LIMK1BMPR210712712963706 Affinity Capture-Western; Two-hybrid
LIMK1BMPR211017212963706 Affinity Capture-Western; Two-hybrid
LIMK1CDKN1C11017214530263 Affinity Capture-Western; Two-hybrid
LIMK1CDKN1C10746214530263 Affinity Capture-Western; Two-hybrid
LIMK1CFL110749910436159 12963706 Biochemical Activity
LIMK1CFL111017210436159 12963706 Biochemical Activity
LIMK1NRG11093329685409 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LIMK1NRG11101729685409 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LIMK1HSPA410954017512523 Affinity Capture-Western
LIMK1HSPA411017217512523 Affinity Capture-Western
LIMK2LIMK11101728980133 Affinity Capture-Western
LIMK2LIMK11101738980133 Affinity Capture-Western
LIMK1LIMK11101728980133 Affinity Capture-Western; Reconstituted Complex
PAK1LIMK111109510559936 Affinity Capture-Western; Reconstituted Complex
PAK1LIMK111017210559936 Affinity Capture-Western; Reconstituted Complex
PAK4LIMK111558611413130 Biochemical Activity; Reconstituted Complex
PAK4LIMK111017211413130 Biochemical Activity; Reconstituted Complex
YWHAZLIMK111336612323073 Reconstituted Complex; Two-hybrid
YWHAZLIMK111017212323073 Reconstituted Complex; Two-hybrid
PARK2LIMK111110517512523 Affinity Capture-Western
PARK2LIMK111017217512523 Affinity Capture-Western
UBCLIMK111316417512523 Affinity Capture-Western
UBCLIMK111017217512523 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104572
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-061212-3'