AutismKB 2.0

Annotation Details for LMNA


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Basic Information Top
Gene Symbol:LMNA ( CDCD1,CDDC,CMD1A,CMT2B1,EMD2,FPL,FPLD,HGPS,IDC,LDP1,LFP,LGMD1B,LMN1,LMNC,LMNL1,PRO1 )
Gene Full Name: lamin A/C
Band: 1q22
Quick LinksEntrez ID:4000; OMIM: 150330; Uniprot ID:LMNA_HUMAN; ENSEMBL ID: ENSG00000160789; HGNC ID: 6636
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16791210
GO:0005635IDA-nuclear envelope18606848
GO:0005635TAS-nuclear envelope-
GO:0005638IEA-lamin filament-
GO:0005654IDA-nucleoplasm27534416
GO:0005654TAS-nucleoplasm-
GO:0005829TAS-cytosol-
GO:0016607IEA-nuclear speck-
GO:0031012IDA-extracellular matrix23979707
GO:0031965IDA-nuclear membrane16791210
GO ID Evidence Qualifier GO_term References
GO:0005198IEA-structural molecule activity-
GO:0005515IPI-protein binding10514485
GO ID Evidence Qualifier GO_term References
GO:0007077TAS-mitotic nuclear envelope disassembly-
GO:0007084TAS-mitotic nuclear envelope reassembly-
GO:0008285IMP-negative regulation of cell proliferation27534416
GO:0030334ISS-regulation of cell migration-
GO:0030951ISS-establishment or maintenance of microtubule cytoskeleton polarity-
GO:0034504ISS-protein localization to nucleus-
GO:0035105IEA-sterol regulatory element binding protein import into nucleus-
GO:0036498TAS-IRE1-mediated unfolded protein response-
GO:0055015IEA-ventricular cardiac muscle cell development-
GO:0071456IEP-cellular response to hypoxia20810912
GO:0072201IEA-negative regulation of mesenchymal cell proliferation-
GO:0090201IEA-negative regulation of release of cytochrome c from mitochondria-
GO:0090343IDA-positive regulation of cell aging20458013
GO:1900180IEA-regulation of protein localization to nucleus-
GO:2001237IEA-negative regulation of extrinsic apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LMNAALOX1211018610727209 Affinity Capture-Western; Two-hybrid
LMNAALOX1210674010727209 Affinity Capture-Western; Two-hybrid
LMNACTNNB110788015355978 Affinity Capture-Western
LMNACTNNB111018615355978 Affinity Capture-Western
LMNATOR1A1101868324822 Reconstituted Complex
LMNATOR1A1081938324822 Reconstituted Complex
LMNAEMD10832510673356 11173535 12670476 12755701 17620012 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LMNAEMD11018610673356 11173535 12670476 12755701 17620012 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LMNAING110983318836436 Affinity Capture-Western
LMNAING111018618836436 Affinity Capture-Western
RB1LMNA1118608278403 Reconstituted Complex
RB1LMNA1101868278403 Reconstituted Complex
TOR1AIP1LMNA1175438324822 Reconstituted Complex
TOR1AIP1LMNA1101868324822 Reconstituted Complex
NARFLMNA11770910514485 Reconstituted Complex; Two-hybrid
NARFLMNA11018610514485 Reconstituted Complex; Two-hybrid
TMPOLMNA11018610984438 12475961 Affinity Capture-Western; Co-localization; Far Western
TMPOLMNA11296710984438 12475961 Affinity Capture-Western; Co-localization; Far Western
LMNB1LMNA11018611792809 Two-hybrid
LMNB1LMNA11018711792809 Two-hybrid
SYNE1LMNA11692811801724 12163176 Affinity Capture-Western; Reconstituted Complex
SYNE1LMNA11018611801724 12163176 Affinity Capture-Western; Reconstituted Complex
SREBF1LMNA11259811929849 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SREBF1LMNA11018611929849 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PRKCALMNA11156412112001 Protein-peptide
PRKCALMNA11018612112001 Protein-peptide
ZNF239LMNA11383112409453 Reconstituted Complex; Two-hybrid
ZNF239LMNA11018612409453 Reconstituted Complex; Two-hybrid
SRRM1LMNA11554416159877 Affinity Capture-MS
SRRM1LMNA11018616159877 Affinity Capture-MS
SRRM2LMNA11707116159877 Affinity Capture-MS
SRRM2LMNA11018616159877 Affinity Capture-MS
KAT5LMNA11018616169070 Two-hybrid
KAT5LMNA11577916169070 Two-hybrid
RBBP4LMNA11186319734887 Reconstituted Complex; Two-hybrid
RBBP4LMNA11018619734887 Reconstituted Complex; Two-hybrid
BANF1LMNA11018619759913 Affinity Capture-MS
BANF1LMNA11434219759913 Affinity Capture-MS
FYCO1LMNA12266920562859 Affinity Capture-MS
FYCO1LMNA11018620562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
LMNArs1468772, rs2485662, rs2485664, rs2485668, rs505058, rs915179 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:96794
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-020424-3'