AutismKB 2.0

Annotation Details for LPL


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Basic Information Top
Gene Symbol:LPL ( HDLCQ11,LIPD )
Gene Full Name: lipoprotein lipase
Band: 8p21.3
Quick LinksEntrez ID:4023; OMIM: 609708; Uniprot ID:LIPL_HUMAN; ENSEMBL ID: ENSG00000175445; HGNC ID: 6677
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space2340307
GO:0005886IEA-plasma membrane-
GO:0009986IEA-cell surface-
GO:0031012IEA-extracellular matrix-
GO:0031225IEA-anchored component of membrane-
GO:0034361IEA-very-low-density lipoprotein particle-
GO:0042627IEA-chylomicron-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004465IDA-lipoprotein lipase activity2110364
GO:0004465IMP-lipoprotein lipase activity25149060
GO:0004465ISS-lipoprotein lipase activity10727238
GO:0004620ISS-phospholipase activity10727238
GO:0004806IDA-triglyceride lipase activity182536
GO:0004806ISS-triglyceride lipase activity10727238
GO:0005102IPI-receptor binding10085125
GO:0005515IPI-protein binding20124439
GO:0008201IDA-heparin binding2110364
GO:0017129IEA-triglyceride binding-
GO:0034185IPI-apolipoprotein binding15178420
GO ID Evidence Qualifier GO_term References
GO:0001523TAS-retinoid metabolic process-
GO:0006633IC-fatty acid biosynthetic process3973011
GO:0006633IDA-fatty acid biosynthetic process182536
GO:0006633ISS-fatty acid biosynthetic process-
GO:0006641ISS-triglyceride metabolic process10727238
GO:0006644ISS-phospholipid metabolic process10727238
GO:0009409IEA-response to cold-
GO:0009749ISS-response to glucose-
GO:0010744IC-positive regulation of macrophage derived foam cell differentiation12573449
GO:0010886IMP-positive regulation of cholesterol storage12573449
GO:0010890IMP-positive regulation of sequestering of triglyceride12573449
GO:0019432IDA-triglyceride biosynthetic process27578112
GO:0019433IDA-triglyceride catabolic process182536
GO:0019433ISS-triglyceride catabolic process-
GO:0034371IC-chylomicron remodeling3973011
GO:0034371TAS-chylomicron remodeling-
GO:0034372IDA-very-low-density lipoprotein particle remodeling3973011
GO:0034372ISS-very-low-density lipoprotein particle remodeling-
GO:0042493IEA-response to drug-
GO:0042632IMP-cholesterol homeostasis25149060
GO:0050729IC-positive regulation of inflammatory response25149060
GO:0051004TAS-regulation of lipoprotein lipase activity-
GO:0055096IMP-low-density lipoprotein particle mediated signaling25149060
GO:0070328IGI-triglyceride homeostasis17018885
GO:0090197IMP-positive regulation of chemokine secretion25149060
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LPLEMD11020512755701 Two-hybrid
LPLEMD10832512755701 Two-hybrid
LRP1LPL1102051281473 7510694 7989348 Reconstituted Complex
LRP1LPL1102151281473 7510694 7989348 Reconstituted Complex
VLDLRLPL1102057592875 Reconstituted Complex
VLDLRLPL1132777592875 Reconstituted Complex
LRP2LPL1102167686151 Reconstituted Complex
LRP2LPL1102057686151 Reconstituted Complex
COPS6LPL11617616169070 Two-hybrid
COPS6LPL11020516169070 Two-hybrid
LUC7L2LPL11020516169070 Two-hybrid
LUC7L2LPL11964616169070 Two-hybrid
KIAA1377LPL11020516169070 Two-hybrid
KIAA1377LPL12161716169070 Two-hybrid
PTPN4LPL11020516169070 Two-hybrid
PTPN4LPL11174116169070 Two-hybrid
RPL18ALPL11020516169070 Two-hybrid
RPL18ALPL11206216169070 Two-hybrid
UBE2ZLPL11020516169070 Two-hybrid
UBE2ZLPL12241916169070 Two-hybrid
ASCC2LPL11020516169070 Two-hybrid
ASCC2LPL12392116169070 Two-hybrid
PLK1LPL11020519596235 Affinity Capture-MS
PLK1LPL11136219596235 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
LPLrs268, rs285, rs320, rs328 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:96820
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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