AutismKB 2.0

Annotation Details for LRP1


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Basic Information Top
Gene Symbol:LRP1 ( A2MR,APOER,APR,CD91,FLJ16451,IGFBP3R,LRP,MGC88725,TGFBR5 )
Gene Full Name: low density lipoprotein receptor-related protein 1
Band: 12q13.3
Quick LinksEntrez ID:4035; OMIM: 107770; Uniprot ID:LRP1_HUMAN; ENSEMBL ID: ENSG00000123384; HGNC ID: 6692
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005730IDA-nucleolus-
GO:0005765IDA-lysosomal membrane17897319
GO:0005768IEA-endosome-
GO:0005829IDA-cytosol-
GO:0005886TAS-plasma membrane14645246
GO:0005887ISS-integral component of plasma membrane-
GO:0005905IEA-clathrin-coated pit-
GO:0005925IDA-focal adhesion21423176
GO:0016020NAS-membrane23386614
GO:0030136IEA-clathrin-coated vesicle-
GO:0030425IEA-dendrite-
GO:0030666TAS-endocytic vesicle membrane-
GO:0043025IEA-neuronal cell body-
GO:0043235IDA-receptor complex23382219
GO:0098797TAS-plasma membrane protein complex21289173
GO ID Evidence Qualifier GO_term References
GO:0002020IEA-protease binding-
GO:0003723IDA-RNA binding22658674
GO:0004872TAS-receptor activity21289173
GO:0005041TAS-low-density lipoprotein receptor activity-
GO:0005509ISS-calcium ion binding-
GO:0005515IPI-protein binding8626514
GO:0016964IMP-alpha-2 macroglobulin receptor activity26142438
GO:0016964TAS-alpha-2 macroglobulin receptor activity21289173
GO:0030226TAS-apolipoprotein receptor activity21289173
GO:0032403IDA-protein complex binding8626514
GO:0034185IDA-apolipoprotein binding2779654
GO:0034185IPI-apolipoprotein binding18635818
GO:0042954NAS-lipoprotein transporter activity3266596
GO:0043395TAS-heparan sulfate proteoglycan binding21289173
GO:0070325IC-lipoprotein particle receptor binding18635818
GO ID Evidence Qualifier GO_term References
GO:0001523TAS-retinoid metabolic process-
GO:0002265ISS-astrocyte activation involved in immune response-
GO:0006629TAS-lipid metabolic process21289173
GO:0006898IMP-receptor-mediated endocytosis23152628
GO:0006898ISS-receptor-mediated endocytosis-
GO:0006898TAS-receptor-mediated endocytosis-
GO:0007205IEA-protein kinase C-activating G-protein coupled receptor signaling pathway-
GO:0007568IEA-aging-
GO:0008283IEA-cell proliferation-
GO:0010715TAS-regulation of extracellular matrix disassembly14645246
GO:0010875ISS-positive regulation of cholesterol efflux-
GO:0010977IEA-negative regulation of neuron projection development-
GO:0014912ISS-negative regulation of smooth muscle cell migration-
GO:0021987IEA-cerebral cortex development-
GO:0030178ISS-negative regulation of Wnt signaling pathway-
GO:0031623TAS-receptor internalization22293988
GO:0032370ISS-positive regulation of lipid transport-
GO:0032374ISS-regulation of cholesterol transport-
GO:0032429ISS-regulation of phospholipase A2 activity-
GO:0032956ISS-regulation of actin cytoskeleton organization-
GO:0035909ISS-aorta morphogenesis-
GO:0042157IEA-lipoprotein metabolic process-
GO:0042953NAS-lipoprotein transport3266596
GO:0043277ISS-apoptotic cell clearance-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0045056TAS-transcytosis22293988
GO:0045732IMP-positive regulation of protein catabolic process24305823
GO:0045732ISS-positive regulation of protein catabolic process-
GO:0051222IEA-positive regulation of protein transport-
GO:0051246ISS-regulation of protein metabolic process-
GO:0097242TAS-amyloid-beta clearance19098903
GO:1904646ISS-cellular response to amyloid-beta-
GO:1905167IMP-positive regulation of lysosomal protein catabolic process23152628
GO:2000587ISS-negative regulation of platelet-derived growth factor receptor-beta signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
LRP1A2M11021510652313 Co-crystal Structure
LRP1A2M10652410652313 Co-crystal Structure
LRP1APBA211021510827173 Two-hybrid
LRP1APBA210681810827173 Two-hybrid
LRP1APBB11068199837937 Reconstituted Complex; Two-hybrid
LRP1APBB11102159837937 Reconstituted Complex; Two-hybrid
LRP1CALCR10725012821648 Affinity Capture-Western; Reconstituted Complex
LRP1CALCR11021512821648 Affinity Capture-Western; Reconstituted Complex
LRP1CALR11021514980518 Affinity Capture-Western
LRP1CALR10726214980518 Affinity Capture-Western
LRP1CANX11021514980518 Affinity Capture-Western
LRP1CANX10727114980518 Affinity Capture-Western
LRP1DAB11102159837937 10827173 Reconstituted Complex; Two-hybrid
LRP1DAB11079709837937 10827173 Reconstituted Complex; Two-hybrid
LRP1DAB211021511247302 Reconstituted Complex
LRP1DAB210797111247302 Reconstituted Complex
LRP1DLG411021510827173 Reconstituted Complex; Two-hybrid
LRP1DLG410808610827173 Reconstituted Complex; Two-hybrid
LRP1F811021512522143 Reconstituted Complex
LRP1F810845512522143 Reconstituted Complex
LRP1F911021512522212 Reconstituted Complex
LRP1F910845612522212 Reconstituted Complex
LRP1LIPC1102157721852 Reconstituted Complex
LRP1LIPC1101787721852 Reconstituted Complex
LRP1LPL1102051281473 7510694 7989348 Reconstituted Complex
LRP1LPL1102151281473 7510694 7989348 Reconstituted Complex
LRPAP1LRP11102151374383 Reconstituted Complex
LRPAP1LRP11102211374383 Reconstituted Complex
PLATLRP11102151502153 10632583 Reconstituted Complex
PLATLRP11113431502153 10632583 Reconstituted Complex
THBS1LRP11129157775583 9045712 14991768 Reconstituted Complex
THBS1LRP11102157775583 9045712 14991768 Reconstituted Complex
MDKLRP111021510772929 Affinity Capture-MS
MDKLRP111035710772929 Affinity Capture-MS
GIPC1LRP111597810827173 Reconstituted Complex; Two-hybrid
GIPC1LRP111021510827173 Reconstituted Complex; Two-hybrid
MAPK8IP2LRP111021510827173 Reconstituted Complex; Two-hybrid
MAPK8IP2LRP111708610827173 Reconstituted Complex; Two-hybrid
SYNJ2BPLRP112061410827173 Reconstituted Complex; Two-hybrid
SYNJ2BPLRP111021510827173 Reconstituted Complex; Two-hybrid
ITGB1BP1LRP111468910827173 Reconstituted Complex; Two-hybrid
ITGB1BP1LRP111021510827173 Reconstituted Complex; Two-hybrid
MAPK8IP1LRP111486410827173 Reconstituted Complex; Two-hybrid
MAPK8IP1LRP111021510827173 Reconstituted Complex; Two-hybrid
NOS1APLRP111021510827173 Reconstituted Complex; Two-hybrid
NOS1APLRP111507110827173 Reconstituted Complex; Two-hybrid
ANAPC10LRP111566510827173 Two-hybrid
ANAPC10LRP111021510827173 Two-hybrid
SCN3ALRP111223310827173 Two-hybrid
SCN3ALRP111021510827173 Two-hybrid
PLAURLRP111021511359936 Affinity Capture-Western; Reconstituted Complex
PLAURLRP111134511359936 Affinity Capture-Western; Reconstituted Complex
GULP1LRP111021511729193 Reconstituted Complex
GULP1LRP111955011729193 Reconstituted Complex
SHC1LRP111021511854294 12789267 Affinity Capture-Western; Reconstituted Complex
SHC1LRP111236111854294 12789267 Affinity Capture-Western; Reconstituted Complex
SRCLRP111021511854294 Biochemical Activity
SRCLRP111259211854294 Biochemical Activity
PDGFBLRP111021511854294 Reconstituted Complex
PDGFBLRP111118111854294 Reconstituted Complex
SNX17LRP111512812169628 Reconstituted Complex
SNX17LRP111021512169628 Reconstituted Complex
KAT5LRP111021512888553 FRET
KAT5LRP111577912888553 FRET
MMP14LRP111021514645246 Affinity Capture-Western
MMP14LRP111046614645246 Affinity Capture-Western
PDIA2LRP112224014980518 Affinity Capture-Western
PDIA2LRP111021514980518 Affinity Capture-Western
SERPINE1LRP111021515001579 Affinity Capture-Western
SERPINE1LRP111109115001579 Affinity Capture-Western
USP3LRP111021519615732 Affinity Capture-MS
USP3LRP111528519615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
LRP1LRP_5'VNTR, rs11172124, rs1799986, rs1800127, rs1800154, rs1800164, rs1800165, rs1800174, rs1800181, rs2075699, rs2228186, rs2306692, rs7956957, rs9669595 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
LRP1rs1799986 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:96828
  • Data Attributes: MGI curated and HomoloGene calculated
No data